“Adenosine 5'-tetraphosphate”的意思、由来-开放百科全书

词条

Adenosine 5'-tetraphosphate

释义

Functions
Rabbits Rats
References

{{Multiple issues|{{primary sources|date=May 2017}}{{technical|date=May 2017}}}}{{Chembox
| ImageFile = Adenosine tetraphosphate.svg
| ImageSize = 200px
| ImageAlt =
| IUPACName = Adenosine 5'-(pentahydrogen tetraphosphate)
| OtherNames = Adenosine tetraphosphate
| Section1 = {{Chembox Identifiers
| CASNo =
| ChEBI = 18334
| SMILES = Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O
| InChI=1S/C10H17N5O16P4/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(28-10)1-27-33(21,22)30-35(25,26)31-34(23,24)29-32(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H,25,26)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1
| InChIKey=WWMWAMFHUSTZTA-KQYNXXCUSA-N
| PubChem = 14003
| ChemSpiderID = 13390
| Section2 = {{Chembox Properties
| C=10|H=17|N=5|O=16|P=4
| Appearance =
| Density =
| MeltingPt =
| BoilingPt =
| Solubility =
| Section3 = {{Chembox Hazards
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Adenosine 5'-tetraphosphate, Ap4 or ATPP is a nucleotide. It is produced from ATP and triphosphate (P₃) through the action of acetyl—CoA synthetase.^[1] Acetyl—CoA synthetase also produces adenosine 5'-pentaphosphate through the reaction of ADP and tetraphosphate (P₄).

Functions

ATPP has been found to play physiological roles in some mammals.

Rabbits

ATPP is a constituent of aqueous humor in rabbits, where it was found to reduce the intraocular pressure.^[2]

Rats

ATPP has been suggested to play a regulatory role in rat aorta.

References

1. ^{{cite journal| author1=Guranowski, A.|author2=Günther Sillero, M.A.|author3=Sillero, A.| title=Adenosine 5'-tetraphosphate and adenosine 5'-pentaphosphate are synthesized by yeast acetyl coenzyme A synthetase. | journal=J Bacteriol | year= 1994 | volume= 176 | issue= 10 | pages= 2986–90 | pmid=7910605 | doi= | pmc=205455 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7910605 }}
2. ^{{Cite journal|last=Pintor|first=Jesús|last2=Peláez|first2=Teresa|last3=Peral|first3=Assumpta|date=February 2004|title=Adenosine tetraphosphate, Ap4, a physiological regulator of intraocular pressure in normotensive rabbit eyes|journal=The Journal of Pharmacology and Experimental Therapeutics|volume=308|issue=2|pages=468–473|doi=10.1124/jpet.103.058669|issn=0022-3565|pmid=14600249}}

1 : Nucleotides

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