“AKR1C2”的意思、由来-开放百科全书

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AKR1C2

释义

References
External links

{{Infobox gene}}Aldo-keto reductase family 1 member C2, also known as bile acid binding protein, 3α-hydroxysteroid dehydrogenase type 3, and dihydrodiol dehydrogenase type 2, is an enzyme that in humans is encoded by the AKR1C2 gene.^[1]

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols using NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme binds bile acid with high affinity, and shows minimal 3α-hydroxysteroid dehydrogenase activity. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding two different isoforms have been found for this gene.^[1]

References

1. ^¹{{cite web | title = Entrez Gene: AKR1C2 aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase) |publisher=National Center for Biotechnology Information, U.S. National Library of Medicine | url = https://www.ncbi.nlm.nih.gov/gene/1646| accessdate = }} {{PD-notice}}

External links

{{UCSC gene info|AKR1C2}}

{{PDB Gallery|geneid=1646}}{{Alcohol oxidoreductases}}{{Enzymes}}{{Portal bar|Molecular and Cellular Biology|border=no}}{{gene-10-stub}}

1 : EC 1.1.1

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