| 词条 | Alfredo Pavlovsky |
| 释义 |
Life and careerBorn to a Russian immigrant and a mother from {{w|Mendoza Province}}, Pavlovsky graduated in medicine in 1931. He worked as Bernardo Houssay's assistant professor in {{w|phisiology}}.[1] In 1936 Pavlovsky established in {{w|Boston}} and started working with Drs. George Minot and William P. Murphy, both Nobel Prize laureates. During that stay, Pavlovsky met William Dameshek, the founder of the American Society of Hematology.[1] Back in his country, Pavlovsky founded the Haemophilia Foundation (Fundación de la Hemofilia)[3] in 1944 and the Foundation to Combat Leukemia (Fundación para Combatir la Leucemia) (FUNDALEU) in 1956, with the purpose to advance etiologic research and treatment of these diseases. He was the co-founder of the International Society of Hematology.[1] In 1955, Pavlovsky was appointed Director of the newly established Medicine Nacional Academy's Hematologic Research Institute (Instituto de Investigaciones Hematológicas de la Academia Nacional de Medicina). He died in 1984, with 5 children and 19 grandchildren.[1] AchievementsIn 1944, Pavlovsky mixed the plasmas from two different patients with haemophilia and obtained mutual correction of the defect.[4] He later discovered that haemophilia can be split in two types.[1] The different factor deficiencies would be distinguished in the 1950s and 1960s.[2] In 1947 he reported in Buenos Aires that "occasionally (in vitro) the blood of some of the haemophilic patients with a greatly prolonged clotting time…when added to other haemophilic blood possessed a coagulant action nearly as effective as normal blood". This finding would later be known to happen due to the normal level of factor VIII in the plasma of patients with haemophilia B correcting the defect in patients with the much commoner form, haemophilia A.[5] See also
References1. ^1 2 3 4 5 {{cite web |title=Dr. Alfredo Pavlovsky |url=https://www.fundaleu.org/dr-alfredo-pavlovsky/ |website=fundaleu.org |accessdate=6 January 2019}} 2. ^1 {{cite web |title=A Brief History of Hemophilia Treatment |url=https://hemophilianewstoday.com/2017/12/12/brief-history-hemophilia-treatment-3/ |website=hemophilianewstoday.com |accessdate=6 January 2019|date=2017-12-12 }} 3. ^{{cite web |title=ANM |url=https://www.acamedbai.org.ar/declaraciones/27.php |website=acamedbai.org.ar |accessdate=6 January 2019}} 4. ^{{cite book |last1=Hougie |first1=Cecil |title=Thrombosis and Bleeding: An Era of Discovery |url=https://books.google.com/?id=L7-b3PRcLhIC&pg=PA102&lpg=PA102&dq=alfredo+pavlovsky+hemophilia#v=onepage&q=alfredo%20pavlovsky%20hemophilia&f=false|isbn=9781412032407 |date=December 2004 }} 5. ^{{cite journal |last1=Giangrande |first1=Paul L. F. |title=Six Characters in Search of An Author: The History of the Nomenclature of Coagulation Factors |journal=British Journal of Haematology |volume=121 |issue=5 |pages=703–712 |doi=10.1046/j.1365-2141.2003.04333.x |year=2003 }} 3 : 1907 births|1984 deaths|Argentine scientists |
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