| 词条 | Algestone acetonide |
| 释义 |
| Verifiedfields = | Watchedfields = | verifiedrevid = | IUPAC_name = (1R,2S,4R,8S,9S,12S,13R)-8-acetyl-6,6,9,13-tetramethyl-5,7-dioxapentacyclo[10.8.0.0²,⁹.0⁴,⁸.0¹³,¹⁸]icos-17-en-16-one | image = Algestone acetonide.svg | width = 225px | tradename = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = | class = Progestin; Progestogen | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = | CAS_number = 4968-09-6 | CAS_supplemental = | ATC_prefix = | ATC_suffix = | PubChem = 11740874 | DrugBank_Ref = | DrugBank = | ChemSpiderID_Ref = | ChemSpiderID = 9915579 | UNII = WXD8I4Y1IH | ChEMBL = 2105960 | ChEBI = 49320 | KEGG = D02808 | synonyms = W-3395; Alfasone acetonide; Alphasone acetonide; Algestone 16α,17α-acetonide; 16α,17α-Isopropylidenedioxyprogesterone; 16α,17α-(Isopropylidenedioxy)pregn-4-ene-3,20-dione | C=24 | H=34 | O=4 | molecular_weight = 386.524 g/mol | SMILES = CC(=O)[C@@]12[C@@H](C[C@@H]3[C@@]1(CC[C@H]4[C@H]3CCC5=CC(=O)CC[C@]45C)C)OC(O2)(C)C | StdInChI_Ref = | StdInChI = 1S/C24H34O4/c1-14(25)24-20(27-21(2,3)28-24)13-19-17-7-6-15-12-16(26)8-10-22(15,4)18(17)9-11-23(19,24)5/h12,17-20H,6-11,13H2,1-5H3/t17-,18+,19+,20-,22+,23+,24-/m1/s1 | StdInChIKey_Ref = | StdInChIKey = LSWBQIAZNGURQV-WTBIUSKOSA-N }}Algestone acetonide (developmental code name W-3395), also known as algestone 16α,17α-acetonide or 16α,17α-isopropylidenedioxyprogesterone, is a progestin which was never marketed.[1][2] It is the acetonide cyclic ketal of algestone.[1][2] Another progestin, algestone acetophenide, in contrast, has been marketed.[1][2] Chemistry{{See also|List of progestogens|List of progestogen esters#Cyclic ketals of progesterone derivatives}}References1. ^1 2 {{cite book|author=J. Elks|title=The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies|url=https://books.google.com/books?id=0vXTBwAAQBAJ&pg=PA27|date=14 November 2014|publisher=Springer|isbn=978-1-4757-2085-3|pages=27–}} {{Progesterone receptor modulators}}{{DEFAULTSORT:Algestone Acetonide}}2. ^1 2 {{cite book|author1=I.K. Morton|author2=Judith M. Hall|title=Concise Dictionary of Pharmacological Agents: Properties and Synonyms|url=https://books.google.com/books?id=tsjrCAAAQBAJ&pg=PA10|date=6 December 2012|publisher=Springer Science & Business Media|isbn=978-94-011-4439-1|pages=10–}} 7 : Abandoned drugs|Acetonides|Diketones|Diols|Pregnanes|Progestogens|Steroid cyclic ketals |
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