| 词条 | Alpha-Zearalenol |
| 释义 |
| Verifiedfields = | Watchedfields = | verifiedrevid = | drug_name = α-Zearalenol | IUPAC_name = (2E,7R,11S)-7,15,17-trihydroxy-11-methyl-12-oxabicyclo[12.4.0]octadeca-1(14),2,15,17-tetraen-13-one | image = Alpha Zearalenol.svg | width = | tradename = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = | CAS_number = 36455-72-8 | CAS_supplemental = | ATC_prefix = | ATC_suffix = | ATC_supplemental = | PubChem = 5284645 | IUPHAR_ligand = | DrugBank_Ref = | DrugBank = | ChemSpiderID_Ref = | ChemSpiderID = 4447689 | UNII = 59D4EVJ5KC | KEGG = C14750 | ChEBI = 35065 | ChEMBL = 371463 | C=18 | H=24 | O=5 | molecular_weight = 320.3802 g/mol | SMILES = C[C@H]1CCC[C@@H](CCC/C=C/C2=CC(=CC(=C2C(=O)O1)O)O)O | StdInChI_Ref = | StdInChI = 1S/C18H24O5/c1-12-6-5-9-14(19)8-4-2-3-7-13-10-15(20)11-16(21)17(13)18(22)23-12/h3,7,10-12,14,19-21H,2,4-6,8-9H2,1H3/b7-3+/t12-,14+/m0/s1 | StdInChIKey_Ref = | StdInChIKey = FPQFYIAXQDXNOR-QDKLYSGJSA-N | synonyms = alpha-Zearalenol; trans-Zearalenol; 2,4-Dihydroxy-6-(6α,10-dihydroxy-trans-1-undecenyl)benzoic acid μ-lactone }}α-Zearalenol is a nonsteroidal estrogen of the resorcylic acid lactone group related to mycoestrogens found in Fusarium spp.[1] It is the α epimer of β-zearalenol and along with β-zearalenol is a major metabolite of zearalenone formed mainly in the liver but also to a lesser extent in the intestines during first-pass metabolism.[2][3] A relatively low proportion of β-zearalenol is formed from zearalenone compared to α-zearalenol in humans.[3] α-Zearalenol is about 3- to 4-fold more potent as an estrogen relative to zearalenone.[1] See also
References1. ^1 {{cite book|author=J. Chelkowski|title=Fusarium: Mycotoxins, Taxonomy, Pathogenicity|url=https://books.google.com/books?id=_1KeBQAAQBAJ&pg=PA85|date=28 June 2014|publisher=Elsevier Science|isbn=978-1-4832-9785-9|pages=85–}} {{Estrogen receptor modulators}}{{DISPLAYTITLE:alpha-Zearalenol}}{{DEFAULTSORT:Zearalenol, alpha-}}2. ^{{cite book|author1=Naresh Magan|author2=Monica Olsen|title=Mycotoxins in Food: Detection and Control|url=https://books.google.com/books?id=CZ3iEhPeejoC&pg=PA356|year=2004|publisher=Woodhead Publishing|isbn=978-1-85573-733-4|pages=356–}} 3. ^1 {{cite book|author=G. S. Eriksen|title=Fusarium Toxins in Cereals: A Risk Assessment|url=https://books.google.com/books?id=jU5Wx8LkZHUC&pg=PA61|year=1998|publisher=Nordic Council of Ministers|isbn=978-92-893-0149-7|pages=61–}} 4 : Lactones|Mycoestrogens|Mycotoxins|Resorcinols |
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