| 词条 | Von Hippel–Lindau binding protein 1 |
| 释义 |
|Name=von Hippel-Lindau binding protein 1 |caption= |image= |width= |HGNCid=12662 |Symbol=VBP1 |AltSymbols= |EntrezGene=7411 |OMIM=300133 |RefSeq=NM_003372 |UniProt=P61758 |PDB= |ECnumber= |Chromosome=X |Arm=q |Band=28 |LocusSupplementaryData= }}Von Hippel–Lindau binding protein 1 (VBP1), also known as "prefoldin 3", is a chaperone protein that binds to von Hippel–Lindau protein and transports it from perinuclear granules to the nucleus or cytoplasm inside the cell.[1] It is also involved in transporting nascent polypeptides to cytosolic chaperonins for post-translational folding.[2] VBP1 is a 197–amino acid heterohexamer comprising two prefoldin-α and four prefoldin-β subunits,[2] and is a member of the prefoldin-α subunit family.[3] It is ubiquitously expressed in tissues, and is located in the cell in the nucleus and cytoplasm.[3] The VBP1 gene is located at Xq28.[4] Homologues are known to exist between human VBP1 and proteins in mice, Drosophila and C. elegans.[2] See also
References1. ^{{cite journal | vauthors = Tsuchiya H, Iseda T, Hino O | last-author-amp = yes | title = Identification of a novel protein (VBP-1) binding to the von Hippel–Lindau (VHL) tumor suppressor gene product | journal = Cancer Research | volume = 56 | year = 1996 | pages = 2881–5 | pmid = 8674032 | issue = 13}} 2. ^1 2 {{cite web | title = GenAtlas report: VBP1 | url = http://www.dsi.univ-paris5.fr/genatlas/fiche.php?symbol=VBP1 | date = 2003-01-17 | accessdate = 2007-07-17}} 3. ^1 {{cite web | title = NiceProt report: P61758 (Prefoldin 3, human) | url = http://www.expasy.org/cgi-bin/niceprot.pl?P61758 | date = 2007-07-10 | accessdate = 2007-07-17}} 4. ^{{cite journal | vauthors = Brinke A, Green PM, Giannelli F | last-author-amp = yes | title = Characterization of the gene (VBP1) and transcript for the von Hippel–Lindau binding protein and isolation of the highly conserved murine homologue | journal = Genomics | volume = 45 | pages = 105–12 | year = 1997 | pmid = 9339366 | doi = 10.1006/geno.1997.4902 | issue = 1}} External links
{{DEFAULTSORT:Von Hippel-Lindau binding protein 1}}{{biochem-stub}} 1 : Proteins |
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