| 词条 | Anatoxin-a(S) |
| 释义 |
| ImageFile = Anatoxin-a(S) skeletal.svg | ImageSize = 200px | ImageAlt = | IUPACName = (5S)-5-[(Dimethylamino)methyl]-1[hydroxy(methoxy)phosphoryl]oxy4,5-dihydro-1H-imidazol-2-amine | OtherNames = | Section1 = {{Chembox Identifiers | CASNo = 103170-78-1 | PubChem = 114989 | KEGG = C19998 | UNII = 4258P76E76 | ChemSpiderID = 102921 | SMILES = CN(C)C[C@H]1CN=C(N1OP(=O)(O)OC)N | StdInChI=1S/C7H17N4O4P/c1-10(2)5-6-4-9-7(8)11(6)15-16(12,13)14-3/h6H,4-5H2,1-3H3,(H2,8,9)(H,12,13)/t6-/m1/s1 | StdInChIKey=FYXHGVMFJYHPFX-ZCFIWIBFSA-N | Section2 = {{Chembox Properties | C=7|H=17|N=4|O=4|P=1 | Appearance = | Density = | MeltingPt = | BoilingPt = | Solubility = | Section3 = {{Chembox Hazards | MainHazards = | FlashPt = | AutoignitionPt = }} Anatoxin-a(S) "Salivary"{{efn|(The "(S)" its name stands for 'salivary' indicating its manner of affliction to distinguish it from a toxin having otherwise the same conventional name. cf. "See also" for aforementioned compound of shared nomenclature.)}} is a naturally occurring cyanotoxin commonly isolated from cyanobacteria (specifically of the genus Anabaena) and causes excess salivation in mammals via inhibition of acetylcholinesterase.[1] Anatoxin-a(S) is structurally a cyclic N-hydroxyguanine organophosphate with a phosphate ester moiety. Toxicity and treatmentThe main mechanism of action for anatoxin-a(S) is by irreversibly inhibiting the active site of acetylcholinesterase leading to excess acetylcholine in the parasympathetic and peripheral nervous systems; inducing poisoning via nicotinic and muscarinic cholinergic receptor stimulation.[2] Treatment of afflicted case by atropine has attested to suppress the muscarinic mediated toxicity; which prevents the namesake salivation that similarly reacts to prevent the toxin's other poisoning symptoms which include lacrimation, urinary incontinence and defecation. Atropine will not, however, counter another mechanism of the compounds toxicity as it also mediates a nicotinic adverse toxicity affecting muscle tremors, fasciculation, convulsions and respiratory failure.{{Citation needed|date=February 2017}} See also
References1. ^{{cite web | url = http://www.sciencedirect.com/topics/page/Anatoxin-a | title = Anatoxin-a}} {{notelist}}{{Cyanotoxins}}{{Neurotoxins}}{{Acetylcholine metabolism and transport modulators}}2. ^{{cite journal | pmid=1770503| year=1991| author1=Hyde| first1=E. G.| title=Anatoxin-a(s), a naturally occurring organophosphate, is an irreversible active site-directed inhibitor of acetylcholinesterase (EC 3.1.1.7)| journal=Journal of Biochemical Toxicology| volume=6| issue=3| pages=195–201| last2=Carmichael| first2=W. W.| doi=10.1002/jbt.2570060305}} 9 : Acetylcholinesterase inhibitors|Neurotoxins|Guanidine alkaloids|Organophosphates|Methyl esters|Cyanotoxins|Nitrogen heterocycles|Amines|Bacterial alkaloids |
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