| 词条 | Andrew McMichael |
| 释义 |
|honorific_suffix={{postnominals|country=GBR|FRS|FMedSci|KBE}} |fetchwikidata=ALL |suppressfields=awards}} Sir Andrew James McMichael, {{postnominals|country=GBR|FRS|FMedSci|KBE}} (born November 1943) is an immunologist, Professor of Molecular Medicine, and previously Director of the Weatherall Institute of Molecular Medicine at the University of Oxford. He is particularly known for his work on T cell responses to viral infections such as influenza and HIV. Early life and educationAndrew was born in London on 8 November 1943 to Sir John McMichael and Joan Catherine .[1] He went to school at St Pauls and then to the University of Cambridge at Gonville and Caius College to study medicine (1962-1968).[2] He went on to complete a PhD at the National Institute for Medical Research supervised by 'Ita' Brigitte Askonas and Alan Williamson. His thesis, published in 1975, is entitled The clonal expression of antibody-forming cells.[3] Career and researchAfter his PhD Andrew completed his postdoctoral research supervised by Hugh McDevitt at Stanford University.[4] In 1977 he returned to the UK to study the T cell response to HIV infection. His research group have created two HIV vaccines which were tested in phase I clinical trials.[5] Andrew became director of the Weatherall Institute of Molecular Medicine in 2000, and remained so until 2012.[6] He founded the MRC Human Immunology Unit in 1998 as Honorary Director until 2010. Andrew has supervised over 55 DPhil students over his career,[5] many of whom have gone on to become leading immunologists themselves:
In addition Andrew supervised postdoctoral researchers, including Tomáš Hanke (Professor of Vaccine Immunology), and Sarah Rowland-Jones (Professor of Immunology).[30][31][32][33] Awards and Honours
Personal lifeIn 1968 Andrew married Kathryn 'Kate' Elizabeth Cross, they have two sons and one daughter.[2] Andrew enjoys walking and skiing at his house in La Salle les Alpes, France.[2] Notable works{{refbegin | 2}}{{Cite journal|last=MCMICHAEL|first=A. J.|last2=TING|first2=A.|last3=ZWEERINK|first3=H. J.|last4=ASKONAS|first4=BRIGITTE A.|date=1977|title=HLA restriction of cell-mediated lysis of influenza virus-infected human cells|url=http://www.nature.com/doifinder/10.1038/270524a0|journal=Nature|language=En|volume=270|issue=5637|pages=524–526|doi=10.1038/270524a0|issn=1476-4687}}{{Cite journal|last=McMichael|first=A. J.|last2=Gotch|first2=F. M.|last3=Noble|first3=G. R.|last4=Beare|first4=P. A.|date=1983-07-07|title=Cytotoxic T-cell immunity to influenza|journal=The New England Journal of Medicine|volume=309|issue=1|pages=13–17|doi=10.1056/NEJM198307073090103|issn=0028-4793|pmid=6602294}}{{Cite journal|last=Townsend|first=A. R.|last2=Rothbard|first2=J.|last3=Gotch|first3=F. M.|last4=Bahadur|first4=G.|last5=Wraith|first5=D.|last6=McMichael|first6=A. J.|date=1986-03-28|title=The epitopes of influenza nucleoprotein recognized by cytotoxic T lymphocytes can be defined with short synthetic peptides|journal=Cell|volume=44|issue=6|pages=959–968|issn=0092-8674|pmid=2420472}}{{Cite journal|last=Phillips|first=R. E.|last2=Rowland-Jones|first2=S.|last3=Nixon|first3=D. F.|last4=Gotch|first4=F. M.|last5=Edwards|first5=J. P.|last6=Ogunlesi|first6=A. O.|last7=Elvin|first7=J. G.|last8=Rothbard|first8=J. A.|last9=Bangham|first9=C. R.|date=1991-12-12|title=Human immunodeficiency virus genetic variation that can escape cytotoxic T cell recognition|journal=Nature|volume=354|issue=6353|pages=453–459|doi=10.1038/354453a0|issn=0028-0836|pmid=1721107}}{{Cite journal|last=Altman|first=J. D.|last2=Moss|first2=P. A.|last3=Goulder|first3=P. J.|last4=Barouch|first4=D. H.|last5=McHeyzer-Williams|first5=M. G.|last6=Bell|first6=J. I.|last7=McMichael|first7=A. J.|last8=Davis|first8=M. M.|date=1996-10-04|title=Phenotypic analysis of antigen-specific T lymphocytes|journal=Science|volume=274|issue=5284|pages=94–96|issn=0036-8075|pmid=8810254}}{{Cite journal|last=Goonetilleke|first=Nilu|last2=Liu|first2=Michael K. P.|last3=Salazar-Gonzalez|first3=Jesus F.|last4=Ferrari|first4=Guido|last5=Giorgi|first5=Elena|last6=Ganusov|first6=Vitaly V.|last7=Keele|first7=Brandon F.|last8=Learn|first8=Gerald H.|last9=Turnbull|first9=Emma L.|date=2009-06-08|title=The first T cell response to transmitted/founder virus contributes to the control of acute viremia in HIV-1 infection|journal=The Journal of Experimental Medicine|volume=206|issue=6|pages=1253–1272|doi=10.1084/jem.20090365|issn=1540-9538|pmc=2715063|pmid=19487423}}{{Cite journal|last=Liu|first=Michael K. P.|last2=Hawkins|first2=Natalie|last3=Ritchie|first3=Adam J.|last4=Ganusov|first4=Vitaly V.|last5=Whale|first5=Victoria|last6=Brackenridge|first6=Simon|last7=Li|first7=Hui|last8=Pavlicek|first8=Jeffrey W.|last9=Cai|first9=Fangping|date=January 2013|title=Vertical T cell immunodominance and epitope entropy determine HIV-1 escape|journal=The Journal of Clinical Investigation|volume=123|issue=1|pages=380–393|doi=10.1172/JCI65330|issn=1558-8238|pmc=3533301|pmid=23221345}}{{Cite journal|last=Fellay|first=Jacques|last2=Shianna|first2=Kevin V.|last3=Ge|first3=Dongliang|last4=Colombo|first4=Sara|last5=Ledergerber|first5=Bruno|last6=Weale|first6=Mike|last7=Zhang|first7=Kunlin|last8=Gumbs|first8=Curtis|last9=Castagna|first9=Antonella|date=2007-08-17|title=A Whole-Genome Association Study of Major Determinants for Host Control of HIV-1|url=http://science.sciencemag.org/content/317/5840/944|journal=Science|language=en|volume=317|issue=5840|pages=944–947|doi=10.1126/science.1143767|issn=0036-8075|pmid=17641165}}{{Cite journal|last=Hill|first=Adrian V. S.|last2=Allsopp|first2=Catherine E. M.|last3=Kwiatkowski|first3=Dominic|last4=Anstey|first4=Nicholas M.|last5=Twumasi|first5=Patrick|last6=Rowe|first6=Pamela A.|last7=Bennett|first7=Stephen|last8=Brewster|first8=David|last9=McMichael|first9=Andrew J.|date=1991|title=Common West African HLA antigens are associated with protection from severe malaria|url=http://www.nature.com/doifinder/10.1038/352595a0|journal=Nature|language=En|volume=352|issue=6336|pages=595–600|doi=10.1038/352595a0|issn=1476-4687|via=}}{{Cite journal|last=Braud|first=Veronique M.|last2=Allan|first2=David S. J.|last3=O'Callaghan|first3=Christopher A.|last4=Söderström|first4=Kalle|last5=D'Andrea|first5=Annalisa|last6=Ogg|first6=Graham S.|last7=Lazetic|first7=Sasha|last8=Young|first8=Neil T.|last9=Bell|first9=John I.|date=1998|title=HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C|url=http://www.nature.com/articles/35869|journal=Nature|language=En|volume=391|issue=6669|pages=795–799|doi=10.1038/35869|issn=1476-4687|via=}}{{Cite journal|last=McMichael|first=Andrew J.|last2=Rowland-Jones|first2=Sarah L.|date=2001-04-19|title=Cellular immune responses to HIV|url=http://www.nature.com/doifinder/10.1038/35073658|journal=Nature|language=En|volume=410|issue=6831|pages=980–987|doi=10.1038/35073658}}{{Cite journal|last=Appay|first=Victor|last2=Dunbar|first2=P. Rod|last3=Callan|first3=Margaret|last4=Klenerman|first4=Paul|last5=Gillespie|first5=Geraldine M.A.|last6=Papagno|first6=Laura|last7=Ogg|first7=Graham S.|last8=King|first8=Abigail|last9=Lechner|first9=Franziska|date=2002|title=Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections|url=http://www.nature.com/articles/nm0402-379|journal=Nature Medicine|language=En|volume=8|issue=4|pages=379–385|doi=10.1038/nm0402-379|issn=1546-170X|via=}}{{Cite journal|last=McMichael|first=Andrew J.|last2=Borrow|first2=Persephone|last3=Tomaras|first3=Georgia D.|last4=Goonetilleke|first4=Nilu|last5=Haynes|first5=Barton F.|date=2010|title=The immune response during acute HIV-1 infection: clues for vaccine development|url=http://www.nature.com/articles/nri2674|journal=Nature Reviews Immunology|language=En|volume=10|issue=1|pages=11–23|doi=10.1038/nri2674|issn=1474-1741|via=|pmc=3119211}}{{refend}}References1. ^{{Cite journal|last=|first=|date=December 2007|title=McMichael, Sir Andrew (James)|url=http://www.ukwhoswho.com/view/10.1093/ww/9780199540884.001.0001/ww-9780199540884-e-26104|journal=|language=en|volume=|pages=|doi=10.1093/ww/9780199540884.001.0001/ww-9780199540884-e-26104|via=}} {{FRS 1992}}{{Authority control}}{{Portal bar|Biography}}{{DEFAULTSORT:McMichael, Andrew}}2. ^1 2 {{Cite web|url=http://www.sylviavetta.co.uk/wp-content/uploads/2014/06/Sir-Andrew-Mc-Michael.pdf|title=Sylvia Vetta meets Professor Sir Andrew McMichael, Oxford University Professor of Molecular Medicine|last=Vetta|first=Sylvia|date=June 2014|website=|archive-url=|archive-date=|dead-url=|access-date=11 February 2018}} 3. ^{{Cite thesis|last=McMichael|first=A. J.|title=The clonal expression of antibody-forming cells|date=1975|degree=Ph.D.|publisher=Council for National Academic Awards (United Kingdom)|url=https://search.proquest.com/docview/301272025|place=England|language=English}} 4. ^{{Cite news|url=https://80000hours.org/2014/01/interview-with-leading-hiv-vaccine-researcher-prof-sir-andrew-mcmichael/|title=Interview with leading HIV vaccine researcher - Prof. Sir Andrew McMichael - 80,000 Hours|date=2014-01-28|work=80,000 Hours|access-date=2018-02-11|language=en-US}} 5. ^1 {{Cite web|url=https://www.ndm.ox.ac.uk/andrew-mcmichael-some-final-words|title=Andrew McMichael: Some final words - Nuffield Department of Medicine|website=www.ndm.ox.ac.uk|access-date=2018-02-11}} 6. ^{{Cite news|url=https://www.jenner.ac.uk/_asset/file/jenner-newsletter-may-2013.pdf|title=Jenner Institute News|last=|first=|date=May 2013|work=|access-date=11 February 2018|archive-url=|archive-date=|dead-url=}} 7. ^{{Cite thesis|last=Nixon|first=Douglas F.|title=Cytotoxic T cell immunity in HIV infection|date=1990|publisher=Thesis DPhil--University of Oxford|url=http://solo.bodleian.ox.ac.uk/primo_library/libweb/action/dlDisplay.do?vid=OXVU1&search_scope=LSCOP_OX&docId=oxfaleph015994492&fn=permalink}} 8. ^{{Cite web|url=https://smhs.gwu.edu/nixon-lab/lab-members|title=Lab Members {{!}} The Nixon Lab {{!}} The GW School of Medicine & Health Sciences|website=smhs.gwu.edu|language=en|access-date=2018-02-11}} 9. ^{{Cite thesis|last=Makgoba|first=M. W.|title=Studies on the polymorphism of HLA class II antigens|date=1983|publisher=Thesis DPhil--University of Oxford|url=http://solo.bodleian.ox.ac.uk/primo_library/libweb/action/dlDisplay.do?vid=OXVU1&search_scope=LSCOP_OX&docId=oxfaleph016544984&fn=permalink}} 10. ^{{Cite thesis|last=Mwau|first=Matilu|title=Clinical evaluation of a candidate HIV-1 Clade A DNA/MVA vaccine designed for Kenya|date=2004|publisher=Thesis DPhil--University of Oxford|url=http://solo.bodleian.ox.ac.uk/primo_library/libweb/action/dlDisplay.do?vid=OXVU1&search_scope=LSCOP_OX&docId=oxfaleph020317840&fn=permalink}} 11. ^{{Cite web|url=http://www.keshop.co.ke/cnhrsite/team/prof-matilu-mwau/|title=Prof. Matilu Mwau – Consortium for National Health Research|website=www.keshop.co.ke|language=en-US|access-date=2018-02-11}} 12. ^{{Cite thesis|last=Bowness|first=Paul|title=Recognition of antigen and superantigen by cytotoxic lymphocytes|date=1993|publisher=Thesis DPhil--University of Oxford|url=http://solo.bodleian.ox.ac.uk/primo_library/libweb/action/dlDisplay.do?vid=OXVU1&search_scope=LSCOP_OX&docId=oxfaleph015948522&fn=permalink}} 13. ^{{Cite web|url=https://www.medsci.ox.ac.uk/study/graduateschool/supervisors/paul-bowness|title=Paul Bowness — University of Oxford, Medical Sciences Division|website=www.medsci.ox.ac.uk|language=en|access-date=2018-02-11}} 14. ^{{Cite thesis|last=Gallimore|first=Awen M.|title=Simian immunodeficiency virus: specific cytotoxic T cell responses in cynomolgus macaques|date=1994|publisher=Thesis DPhil--University of Oxford|url=http://solo.bodleian.ox.ac.uk/primo_library/libweb/action/dlDisplay.do?vid=OXVU1&search_scope=LSCOP_OX&docId=oxfaleph015559769&fn=permalink}} 15. ^{{Cite web|url=http://cancerimmunology.co.uk/gallery|title=The Team|website=cancerimmunology.co.uk|access-date=2018-02-11}} 16. ^{{Cite news|url=http://www.cardiff.ac.uk/people/view/78694-gallimore-awen|title=Professor Awen Gallimore - People - Cardiff University|work=Cardiff University|access-date=2018-02-11|language=en}} 17. ^{{Cite thesis|last=Klenerman|first=Paul|title=Cytotoxic T cell antagonism in HIV infection|date=1995|publisher=Thesis DPhil--University of Oxford|url=http://solo.bodleian.ox.ac.uk/primo_library/libweb/action/dlDisplay.do?vid=OXVU1&search_scope=LSCOP_OX&docId=oxfaleph013635776&fn=permalink}} 18. ^{{Cite web|url=https://www.ndm.ox.ac.uk/principal-investigators/researcher/paul-klenerman|title=Professor Paul Klenerman - Nuffield Department of Medicine|website=www.ndm.ox.ac.uk|access-date=2018-02-12}} 19. ^{{Cite web|url=https://loop.frontiersin.org/people/24218/overview|title=paul Klenerman|website=Loop|language=en|access-date=2018-02-12}} 20. ^{{Cite thesis|last=Barouch|first=Dan H.|title=Peptide binding and presentation by HLA-A2|date=1995|publisher=Thesis DPhil--University of Oxford|url=http://solo.bodleian.ox.ac.uk/primo_library/libweb/action/dlDisplay.do?vid=OXVU1&search_scope=LSCOP_OX&docId=oxfaleph015461784&fn=permalink}} 21. ^{{Cite web|url=https://www.hms.harvard.edu/dms/immunology/fac/Barouch.php|title=Immunology Faculty Member - Dan Barouch, MD, PhD|last=|first=|date=2014-07-14|website=Harvard Medical School|archive-url=|archive-date=|dead-url=|access-date=}} 22. ^{{Cite thesis|last=Hambleton|first=Sophie|title=Notch and immunodominance in CD8+ T cell responses|date=2001|publisher=Thesis DPhil--University of Oxford|url=http://solo.bodleian.ox.ac.uk/primo_library/libweb/action/dlDisplay.do?vid=OXVU1&search_scope=LSCOP_OX&docId=oxfaleph015407144&fn=permalink}} 23. ^{{Cite web|url=http://www.ncl.ac.uk/icm/people/profile/sophiehambleton.html#background|title=Staff Profile - Institute of Cellular Medicine - Newcastle University|website=www.ncl.ac.uk|access-date=2018-02-12}} 24. ^{{Cite web|url=http://www.newcastle-hospitals.org.uk/staff-profiles/16954.aspx|title=Newcastle Hospitals - Hambleton, Dr Sophie|last=http://www.think.eu|first=TH_NK,|website=www.newcastle-hospitals.org.uk|language=en|access-date=2018-02-12}} 25. ^{{Cite thesis|last=Seneviratne|first=Suranjith Luke|title=Investigation of T cells in atopic disease|date=2003|publisher=Thesis DPhil--University of Oxford|url=http://solo.bodleian.ox.ac.uk/primo_library/libweb/action/dlDisplay.do?vid=OXVU1&search_scope=LSCOP_OX&docId=oxfaleph015848563&fn=permalink}} 26. ^{{Cite web|url=https://www.nuffieldhealth.com/consultants/professor-suranjith-seneviratne|title=Professor Suranjith Seneviratne, Allergy Medicine {{!}} Nuffield Health|website=www.nuffieldhealth.com|language=en-GB|access-date=2018-02-12}} 27. ^{{Cite news|url=https://www.ehlers-danlos.com/suranjith-seneviratne/|title=Suranjith Seneviratne, MBBS, MD, FRCP, FRCPath, DPhil, FCCP {{!}} The Ehlers Danlos Society|work=The Ehlers Danlos Society|access-date=2018-02-12|language=en-US}} 28. ^{{Cite thesis|last=Ho|first=Ling-Pei|title=The role of CD1d restricted NKT cells in the immunopathology of sarcoidosis|date=2004|publisher=Thesis DPhil--University of Oxford|url=http://solo.bodleian.ox.ac.uk/primo_library/libweb/action/dlDisplay.do?vid=OXVU1&search_scope=LSCOP_OX&docId=oxfaleph016023825&fn=permalink}} 29. ^{{Cite web|url=https://www.ndm.ox.ac.uk/principal-investigators/researcher/ling-pei-ho|title=Professor Ling-Pei Ho - Nuffield Department of Medicine|website=www.ndm.ox.ac.uk|access-date=2018-02-12}} 30. ^{{Cite web|url=https://www.ndm.ox.ac.uk/principal-investigators/researcher/tomas-hanke|title=Professor Tomas Hanke - Nuffield Department of Medicine|website=www.ndm.ox.ac.uk|access-date=2018-02-12}} 31. ^{{Cite news|url=http://www.internationalinnovation.com/build/wp-content/uploads/2014/08/Toimas_Hanke_Intl_Innovation_147_Research_Media.pdf|title=Outsmarting HIV|last=|first=|date=|work=INTERNATIONAL INNOVATION|access-date=|archive-url=|archive-date=|dead-url=}} 32. ^{{Cite web|url=https://www.ndm.ox.ac.uk/principal-investigators/researcher/sarah-rowland-jones|title=Professor Sarah L Rowland-Jones - Nuffield Department of Medicine|website=www.ndm.ox.ac.uk|access-date=2018-02-12}} 33. ^{{Cite web|url=http://wils-database.embo.org/members_meet.php?action=member&aus=1&member_id=707|title=WiLS Database - Expert Women in Life Sciences|website=wils-database.embo.org|access-date=2018-02-12}} 34. ^{{Cite web|url=https://royalsociety.org/people/andrew-mcmichael-11935/|title=Andrew McMichael|website=royalsociety.org|language=en-gb|access-date=2018-02-11}} 35. ^1 2 3 4 {{Cite news|url=http://www3.imperial.ac.uk/newsandeventspggrp/imperialcollege/newssummary/news_5-5-2010-8-57-11|title=You will shape the future, Imperial College London’s Rector tells new graduates|last=Jones|first=J-P|date=5 May 2010|work=Imperial College London|access-date=11 February 2018|archive-url=|archive-date=|dead-url=}} 36. ^{{Cite web|url=http://www.ashi-hla.org/?page=awards#rose-award|title=Awards - American Society for Histocompatibility and Immunogenetics|website=www.ashi-hla.org|access-date=2018-02-11}} 37. ^{{Cite web|url=https://acmedsci.ac.uk/fellows/fellows-directory/ordinary-fellows/sir-andrew-mcmichael|title=Sir Andrew McMichael {{!}} The Academy of Medical Sciences|website=acmedsci.ac.uk|access-date=2018-02-11}} 38. ^{{Cite web|url=http://hmaward.org.ae/profile.php?id=281|title=Professor Andrew McMichael - Sheikh Hamdan Bin Rashid Al Maktoum Award for Medical Sciences - HMA|website=hmaward.org.ae|language=en-gb|access-date=2018-02-11}} 39. ^{{Cite web|url=https://www.imperial.ac.uk/college.asp?P=7553|title=Imperial College London - Ernst Chain prize for HIV vaccines researcher|website=www.imperial.ac.uk|language=en|access-date=2018-02-11}} 40. ^{{Cite journal|last=Dennis|first=Carina|date=2006-12-13|title=Model Mentors|url=https://www.nature.com/naturejobs/science/articles/10.1038/nj7121-966a|journal=Nature|language=en|volume=444|issue=7121|pages=966–968|doi=10.1038/nj7121-966a}} 41. ^{{Cite journal|date=2006-09-06|title=News in brief|url=http://www.nature.com/doifinder/10.1038/443014a|journal=Nature|language=En|volume=443|issue=7107|pages=14–15|doi=10.1038/443014a}} 42. ^{{Cite news|url=http://news.bbc.co.uk/1/hi/england/oxfordshire/7453489.stm|title=Dame honour for Oxfam executive|date=2008-06-14|access-date=2018-02-11|language=en-GB}} 43. ^{{Cite journal|last=McMichael|first=Andrew J.|date=2013-05-21|title=In pursuit of an HIV vaccine: an interview with Andrew McMichael|url=https://doi.org/10.1186/1741-7007-11-60|journal=BMC Biology|volume=11|pages=60|doi=10.1186/1741-7007-11-60|issn=1741-7007}} 6 : 1943 births|Living people|Fellows of the Royal Society|Knights Bachelor|People educated at St Paul's School, London|Alumni of Gonville and Caius College, Cambridge |
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