| 词条 | Andrew Wilkie (geneticist) |
| 释义 |
| name = Andrew Wilkie | birth_name = Andrew Oliver Mungo Wilkie | image = | image_size = | alt = | caption = | birth_date = {{birth date and age |df=yes|1959|09|14}}[1] | birth_place = | death_date = | death_place = | death_cause = | resting_place = | resting_place_coordinates = | other_names = | residence = | citizenship = | nationality = | fields = Medical genetics | workplaces = University of Oxford | patrons = | education = {{Plainlist|
| alma_mater = | thesis_title = | thesis_url = | thesis_year = | doctoral_advisor = | academic_advisors = | doctoral_students = | notable_students = | known_for = | influences = | influenced = | awards = {{Plainlist|
| spouse = | partner = | children = | signature = | signature_alt = | website = {{URL|ndcls.ox.ac.uk/researchers/researcher/andrew-wilkie}} | footnotes = }}Andrew Oliver Mungo Wilkie (born 14 September 1959)[1] FRS[4] is a clinical geneticist who has been the Nuffield professor of Pathology at the University of Oxford since 2003.[2][3] EducationWilkie was educated at Arnold School, Westminster School and Trinity College, Cambridge where he was awarded a Bachelor of Arts degree in 1980 and a Master of Arts degree in 1984.[1] He moved to Merton College, Oxford where he was awarded a Bachelor of Medicine, Bachelor of Surgery degree in 1983 and subsequently a Doctor of Medicine degree in 1992.[1] ResearchWilkie's research investigates genetic disorders affecting the skull and limbs, especially craniosynostosis[4] – premature fusion of the sutures of the skull. He identified the gene mutation responsible for Apert syndrome and the molecular pathways underlying this and other craniosynostosis conditions. These results have led to many clinical diagnostic tests.[2][5] Wilkie's discovery that the mutation causing Apert syndrome was more common than expected led him to develop the 'selfish selection' theory, which states that there is a proliferation or survival advantage for some mutations in the testis. Over time, sperm-generating cells carrying such mutations become prevalent, explaining why some conditions are more common in children born to older fathers.[2] Wilkie demonstrated that the Ras molecular pathway, the common factor in paternal age effect conditions, is also important in the development of nerves and tumours. Consequently, his work has implications for other diseases, including autism and cancer.[2] His research has been funded by the Medical Research Council (MRC).[6] Awards and honoursWilkie was elected member of the Academy of Medical Sciences in 2002,[7] the European Molecular Biology Organization (EMBO) in 2006[8] and a Fellow of the Royal Society (FRS) in 2013.[2] Personal lifeWilkie is the son of Douglas Robert Wilkie FRS.[1][9] References1. ^1 2 3 4 {{Who's Who | surname = WILKIE | othernames = Prof. Andrew Oliver Mungo | id = U10000244 | volume = 2016 | edition = online Oxford University Press|location=Oxford}} {{subscription required}} {{FRS 2013}}{{Authority control}}{{DEFAULTSORT:Wilkie, Andrew O. M.}}2. ^1 2 3 4 5 6 {{cite web|archiveurl=https://web.archive.org/web/20151117102647/https://royalsociety.org/people/andrew-wilkie-12543/ |archivedate=2015-11-17 |url=https://royalsociety.org/people/andrew-wilkie-12543/ |publisher=Royal Society |location=London |title=Professor Andrew Wilkie FMedSci FRS }} One or more of the preceding sentences incorporates text from the royalsociety.org website where: {{quote|"All text published under the heading 'Biography' on Fellow profile pages is available under Creative Commons Attribution 4.0 International License." --{{cite web|url=https://royalsociety.org/about-us/terms-conditions-policies/ |title=Royal Society Terms, conditions and policies |accessdate=2016-03-09 |deadurl=bot: unknown |archiveurl=https://web.archive.org/web/20150925220834/https://royalsociety.org/about-us/terms-conditions-policies/ |archivedate=2015-09-25 |df= }}}} 3. ^{{cite web|archiveurl=https://web.archive.org/web/20160410085548/http://www.rdm.ox.ac.uk/principal-investigators/researcher/andrew-wilkie|archivedate=2016-04-10|url=http://www.rdm.ox.ac.uk/principal-investigators/researcher/andrew-wilkie|title=Prof Andrew OM Wilkie FRS FMedSci FRCP|publisher=University of Oxford|location=Oxford}} 4. ^{{cite journal|last1=Wilkie|first1=Andrew O. M.|title=Craniosynostosis: genes and mechanisms|journal=Human Molecular Genetics|volume=6|issue=10|year=1997|pages=1647–1656|pmid=9300656|doi=10.1093/hmg/6.10.1647}} 5. ^{{Scopus|id=7005829022 }} 6. ^{{cite web|archiveurl=https://web.archive.org/web/20160411152238/http://gtr.rcuk.ac.uk/person/98B55E8F-21B2-4A6A-9CE2-BB709FCDAD77 |location=Swindon|publisher=Research Councils UK|title=UK government grants awarded to Andrew Wilkie|archivedate=2016-04-11|url=http://gtr.rcuk.ac.uk/person/98B55E8F-21B2-4A6A-9CE2-BB709FCDAD77}} 7. ^1 {{cite web|archiveurl=https://web.archive.org/web/20160411200045/http://www.acmedsci.ac.uk/fellows/fellows-directory/ordinary-fellows/0006055-professor-andrew-wilkie/|archivedate=2016-04-11|url=http://www.acmedsci.ac.uk/fellows/fellows-directory/ordinary-fellows/0006055-professor-andrew-wilkie/|title=Professor Andrew Wilkie FRS FMedSci|publisher=Academy of Medical Sciences|location=London}} 8. ^1 {{cite web|url=http://people.embo.org/profile/andrew-wilkie|archiveurl=https://web.archive.org/web/20160119105124/http://people.embo.org/profile/andrew-wilkie|archivedate=2016-01-19|publisher=EMBO|location=Heidelberg|title=Andrew Wilkie, John Radcliffe Hospital, Oxford, UK}} 9. ^{{cite journal|last1=Woledge|first1=R. C.|title=Douglas Robert Wilkie. 2 October 1922 – 21 May 1998: Elected F.R.S. 1971|journal=Biographical Memoirs of Fellows of the Royal Society|volume=47|issue=0|year=2001|pages=481–495|doi=10.1098/rsbm.2001.0029|pmid=15124650}} 5 : 1959 births|Fellows of the Royal Society|Members of the European Molecular Biology Organization|Fellows of the Academy of Medical Sciences|Living people |
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