| 词条 | Anna Marie Pyle |
| 释义 |
| name = Anna Marie Pyle | alma_mater = Princeton University, Columbia University | workplaces = Yale University, University of Colorado }} Anna Marie Pyle is an American academic who is a Sterling Professor of Molecular, Cellular & Developmental Biology and a Professor of Chemistry at Yale University. and an Investigator for Howard Hughes Medical Institute.[1] Pyle is the president of the RNA Society,[2] the vice-chair of the Science and Technology Steering Committee at Brookhaven National Laboratory, and previously she served as chair of the Macromolecular Structure and Function A Study Section[3] at the National Institutes of Health. Early life and educationPlye grew up in Albuquerque, New Mexico, and it was her that she first became interested in science.[4] But it wasn't until after earning her bachelors degree from Princeton University that she committed to a career in chemistry.[4] In 1990, she graduated from Columbia University with a Ph.D. in chemistry. Pyle went on to postdoc at the University of Colorado until in 1992 she established a research group at Columbia University Medical Cente ResearchPyle joined Yale University in 2002. She researches the architectural features of large RNA molecules and RNA remodeling enzymes using experimental biochemistry and crystallography. such as self-splicing introns and other noncoding RNAs. She has focused her research to understand how large RNAs assemble into specific, stable tertiary structures, and also how ATP-dependent enzymes in the cell recognize and remodel RNA. Specifically, she was successful in crystallizing and solving the structure of a group IIC intron from the bacterium Oceanobacillus iheyensis [5] and moves through the stages of splicing.[6] Pyle's research may be helpful in drug development as RNA’s tertiary structure could provide insight into druggable biomolecules.[7][8] Selected awards and honors
References1. ^1 {{Cite web|url=https://mcdb.yale.edu/people/anna-marie-pyle|title=Anna Marie Pyle, Ph.D. {{!}} Molecular, Cellular and Developmental Biology|website=mcdb.yale.edu|access-date=2019-03-01}} 2. ^{{Cite web|url=https://www.rnasociety.org/|title=RNA Society|access-date=2019-03-01}} 3. ^{{Cite web|url=https://public.csr.nih.gov/StudySections/DBIB/BCMB/MSFA|title=MSFA {{!}} NIH Center for Scientific Review|website=public.csr.nih.gov|access-date=2019-03-01}} 4. ^1 {{Cite web|url=http://www.asbmb.org/asbmbtoday/201510/2016Meeting/Pyle/|title=2016 Annual Meeting Plenary Lecturer: Pyle|website=www.asbmb.org|access-date=2019-03-01}} 5. ^{{Cite journal|last=Toor|first=Navtej|last2=Keating|first2=Kevin S.|last3=Fedorova|first3=Olga|last4=Rajashankar|first4=Kanagalaghatta|last5=Wang|first5=Jimin|last6=Pyle|first6=Anna Marie|date=January 2010|title=Tertiary architecture of the Oceanobacillus iheyensis group II intron|url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2802037/|journal=RNA|volume=16|issue=1|pages=57–69|doi=10.1261/rna.1844010|issn=1355-8382|pmc=2802037|pmid=19952115}} 6. ^{{Cite journal|last=Pyle|first=A. M.|last2=Marcia|first2=M.|date=2012|title=Visualizing Group II Intron Catalysis through the Stages of Splicing.|url=http://www.rcsb.org/pdb/explore/litView.do?structureId=4E8K|journal=Cell|volume=151|pages=497–507|doi=10.2210/pdb4e8k/pdb}} 7. ^{{Cite web|url=https://cen.acs.org/pharmaceuticals/drug-discovery/Targeting-RNAs-tertiary-structure/96/i43|title=Targeting RNA’s tertiary structure|website=Chemical & Engineering News|access-date=2019-03-01}} 8. ^{{Cite journal|last=Pyle|first=Anna Marie|last2=Zandt|first2=Michael C. Van|last3=Lin Yuan|last4=Adams|first4=Rebecca L.|last5=Jagdmann|first5=G. Erik|last6=Fedorova|first6=Olga|date=December 2018|title=Small molecules that target group II introns are potent antifungal agents|url=https://www.nature.com/articles/s41589-018-0142-0|journal=Nature Chemical Biology|volume=14|issue=12|pages=1073–1078|doi=10.1038/s41589-018-0142-0|issn=1552-4469}} 9. ^{{Cite web|url=https://news.yale.edu/2018/07/19/anna-marie-pyle-appointed-sterling-professor|title=Anna Marie Pyle appointed Sterling Professor|date=2018-07-19|website=YaleNews|access-date=2019-03-01}} 10. ^{{Cite web|url=https://www.aaas.org/fellows/historic|title=Historic Fellows|website=American Association for the Advancement of Science|access-date=2019-03-01}} 11. ^{{Cite web|url=https://www.amacad.org/person/anna-marie-pyle|title=Anna Marie Pyle|website=American Academy of Arts & Sciences|access-date=2019-03-01}} 7 : Living people|Yale University faculty|Princeton University alumni|American women biologists|American biochemists|Howard Hughes Medical Investigators|Year of birth missing (living people) |
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