| 词条 | Wakefulness |
| 释义 |
Wakefulness is a daily recurring brain state and state of consciousness in which an individual is conscious and engages in coherent cognitive and behavioral responses to the external world such as communication, ambulation, eating, and sex. Being awake is the opposite of the state of being asleep in which most external inputs to the brain are excluded from neural processing. Effects upon the brainThe longer the brain has been awake, the greater the synchronous firing rates of cerebral cortex neurons. After sustained periods of sleep, both the speed and synchronicity of the neurons firing are shown to decrease.[1][2] Maintenance by the brain{{Main|Ascending reticular activating system |Arousal}}Wakefulness is produced by a complex interaction between multiple neurotransmitter systems arising in the brainstem and ascending through the midbrain, hypothalamus, thalamus and basal forebrain.[3] The posterior hypothalamus plays a key role in the maintenance of the cortical activation that underlies wakefulness. Several systems originating in this part of the brain control the shift from wakefulness into sleep and sleep into wakefulness. Histamine neurons in the tuberomammillary nucleus and nearby adjacent posterior hypothalamus project to the entire brain and are the most wake-selective system so far identified in the brain.[4] Another key system is that provided by the orexins (also known as hypocretins) projecting neurons. These exist in areas adjacent to histamine neurons and like them project widely to most brain areas and associate with arousal.[5] Orexin deficiency has been identified as responsible for narcolepsy.[6] Research suggests that orexin and histamine neurons play distinct, but complementary roles in controlling wakefulness with orexin being more involved with wakeful behavior and histamine with cognition and activation of cortical EEG.[7] It has been suggested the fetus is not awake, with wakefulness occurring in the newborn due to the stress of being born and the associated activation of the locus coeruleus.[8] See also
References1. ^{{cite journal | last1=Vyazovskiy | first1=VV | last2=Olcese | first2=U | last3=Lazimy | first3=YM | last4=Faraguna | first4=U | last5=Esser | cada cosa va con l otro y nada de lo que dice esta página es cierto ?abran los ojo cualquiera edita esto y lo va ser algo muy sen energy source. 2. ^{{cite journal | doi = 10.1016/0301-0082(94)00057-O | last1 = Benington | first1 = JH | last2 = Heller | first2 = HC | title = Restoration of brain energy metabolism as the function of sleep | journal = Progress in Neurobiology | volume = 45 | issue = 4 | pages = 347–60 | year = 1995 | pmid = 7624482 }} 3. ^{{cite journal | last1 = Brown | first1 = RE | last2 = Basheer | first2 = R | last3 = McKenna | first3 = JT | last4 = Strecker | first4 = RE | last5 = McCarley | first5 = RW | title = Control of Sleep and Wakefulness | journal = Physiological Reviews | volume = 92 | pages = 1087–1187 | year = 2012 | pmid = 22811426 | pmc = 3621793 | doi = 10.1152/physrev.00032.2011}}4. ^{{cite journal | last1 = Takahashi | first1 = K | last2 = Lin | first2 = JS | last3 = Sakai | first3 = K | title = Neuronal activity of histaminergic tuberomammillary neurons during wake-sleep states in the mouse | journal = Journal of Neuroscience | volume = 26 | issue = 40 | pages = 10292–8 | year = 2006 | pmid = 17021184 | doi = 10.1523/JNEUROSCI.2341-06.2006 | url = http://www.hal.inserm.fr/inserm-00408027/document }} 5. ^{{cite journal | last1 = Sakurai | first1 = T | title = The neural circuit of orexin (hypocretin): maintaining sleep and wakefulness | journal = Nature Reviews. Neuroscience | volume = 8 | issue = 3 | pages = 171–81 | year = 2007 | pmid = 17299454 | doi = 10.1038/nrn2092 }} 6. ^{{cite journal | doi = 10.1016/S0092-8674(00)81973-X | last1 = Chemelli | first1 = RM | last2 = Willie | first2 = JT | last3 = Sinton | first3 = CM | last4 = Elmquist | first4 = JK | last5 = Scammell | first5 = T | last6 = Lee | first6 = C | last7 = Richardson | first7 = JA | last8 = Williams | first8 = SC | last9 = Xiong | first9 = Y | title = Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation | journal = Cell | volume = 98 | issue = 4 | pages = 437–51 | year = 1999 | pmid = 10481909 }} 7. ^{{cite journal | last1= Anaclet | first1= C. | last2= Parmentier | first2= R. | last3= Ouk | first3= K. | last4= Guidon | first4= G. | last5= Buda | first5= C. | last6= Sastre | first6= J.-P. | last7= Akaoka | first7= H. | last8= Sergeeva | first8= O. A. | last9= Yanagisawa | first9= M. | title= Orexin/Hypocretin and Histamine: Distinct Roles in the Control of Wakefulness Demonstrated Using Knock-Out Mouse Models | journal= Journal of Neuroscience | volume= 29 | issue= 46 | pages= 14423–14438 | year= 2009 | pmid= 19923277 | pmc= 2802289 |doi=10.1523/JNEUROSCI.2604-09.2009}} 8. ^{{cite journal | last1 = Lagercrantz | first1 = H | title = The birth of consciousness | journal = Early human development | volume = 85 | issue = 10 Suppl | pages = S57–8 | year = 2009 | pmid = 19762170 | doi = 10.1016/j.earlhumdev.2009.08.017 }} External links{{Wikiquote}}{{Wiktionary}}
2 : Cognition|Psychological states |
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