“Antibody-vaccine engineered construct”的意思、由来-开放百科全书

Antibody-vaccine engineered construct abbreviated AVEC is a biomolecularly engineered molecule consisting of the two main components: (1) antibody; (2) vaccine. (1) The antibody component is guiding AVEC to the targeted molecule, e.g., to epidermal growth factor receptor 2 (HER2) on breast cancer cells. (2) The vaccine component is eliciting immune response in a vaccinated person, e.g., immune response to the HBV vaccine mounted by the prophylactic immunity gained by vaccination.

Mechanism of action of AVEC relies upon prophylactic immunity acquired through the vaccination against microbials (e.g., viruses, bacteria, etc.) being redirected, amplified, and accelerated against the cancer cells, viruses, or bacteria. For example, the person vaccinated against hepatitis B virus, but suffering from HER2+ breast cancer receives AVEC consisting of the antibody against HER2 and vaccine against HBV (AVEC: anti-HER2 - HBV). Therefore, the prophylactic immunity against HBV is redirected against cancer. By comparison, AVEC attracts the components of the immune response like a lightning-rod attracts the thunderbolts during storms. [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4990520/ 1]

References

1. ^{{cite journal | pmc= 4990520 | pmid=27539579 | doi=10.1186/s40169-016-0111-8 | volume=5 | title=Novel paradigm for immunotherapy of breast cancer by engaging prophylactic immunity against hepatitis B | journal=Clin Transl Med | page=32 | last1 = Malecki | first1 = M | last2 = Sabo | first2 = C | last3 = Foorohar | first3 = A | last4 = Tombokan | first4 = X}}
2. ^{{cite journal|pmc=4990520 | pmid=27539579 | doi=10.1186/s40169-016-0111-8 | volume=5 | title=Novel paradigm for immunotherapy of breast cancer by engaging prophylactic immunity against hepatitis B | journal=Clin Transl Med | page=32 | last1 = Malecki | first1 = M | last2 = Sabo | first2 = C | last3 = Foorohar | first3 = A | last4 = Tombokan | first4 = X}}