Appignanesi is a surname. It may refer to:

• Ennio Appignanesi (1925–2015), Italian Roman Catholic archbishop
• Josh Appignanesi (born 1975), British film director, producer, and screenwriter
• Lisa Appignanesi, British writer, novelist, and campaigner for free expression
• Richard Appignanesi (born 1940), Canadian writer and editor

• The Steam Museum
• The Steam Museum, Straffan
• The Steampunk Album That Cannot Be Named For Legal Reasons
• The Steele home
• The Steele Home
• The Steel Fist
• The Steel Woods
• The Steelyard
• The Steep Ascent
• The Steeplechase
• The Steeples
• The Steet Light: Study of Light
• Thesteia
• The Steinhardt Museum of Natural History
• The Stein Song
• The Stein Song (film)
• The Steinway Tower
• The Stench of Humanity
• The Stepdaughters
• The Stepfather
• The Stepfather (TV series)
• The Stephen Foster Collection and archive
• The Stephen Low Company
• The Step-Mother
• The Stepmother