| 词条 | Arachidonyl trifluoromethyl ketone |
| 释义 |
| ImageFile = Arachidonyl trifluoromethyl ketone.svg | ImageSize = 200px | ImageAlt = | IUPACName = 1,1,1-Trifluoro-6Z,9Z,12Z,15Z-heneicosateraen-2-one | OtherNames ={{bulletedlist|Arachidonic acid trifluoromethyl ketone | Arachidonyltrifluoromethane |Arach-CF3| |AACOCF3}} | Section1 = {{Chembox Identifiers | CASNo = 149301-79-1 | PubChem = 5280436 | SMILES = CCCCC/C=C\\C/C=C\\C/C=C\\C/C=C\\CCCC(=O)C(F)(F)F | InChI=1S/C21H31F3O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(25)21(22,23)24/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3/b7-6-,10-9-,13-12-,16-15- | InChIKey=PLWROONZUDKYKG-DOFZRALJSA-N | ChemSpiderID = 4444095 | Section2 = {{Chembox Properties | C=21|H=31|F=3|O=1 | Appearance = | Density = | MeltingPt = | BoilingPt = | Solubility = | Section3 = {{Chembox Hazards | MainHazards = | FlashPt = | AutoignitionPt = }}Arachidonyl trifluoromethyl ketone (ATK) is an analog of arachidonic acid.[1] that inhibits some isoforms of the enzyme phospholipase A2.[2] Specifically it inhibits the 85 kDa cystolic PLA2 (cPLA2).[2] It has been studied as a neuroprotective agent after spinal cord injury,[2][3] and in animal models of multiple sclerosis.[4] See also
References1. ^{{cite journal |doi=10.1021/bi00074a003|pmid=8018213|title=Slow- and tight-binding inhibitors of the 85-k Da human phospholipase A2|journal=Biochemistry|volume=32|issue=23|pages=5935|year=1993|last1=Street|first1=Ian P.|last2=Lin|first2=Hung Kuei|last3=Laliberte|first3=France|last4=Ghomashchi|first4=Farideh|last5=Wang|first5=Zhaoyin|last6=Perrier|first6=Helene|last7=Tremblay|first7=Nathalie M.|last8=Huang|first8=Zheng|last9=Weech|first9=Philip K.|last10=Gelb|first10=Michael H.}} {{ketone-stub}}2. ^1 2 {{cite journal |doi=10.1186/s12974-015-0311-y|pmid=25971887|pmc=4436116|title=Oral administration of cytosolic PLA2 inhibitor arachidonyl trifluoromethyl ketone ameliorates cauda equina compression injury in rats|journal=Journal of Neuroinflammation|volume=12|pages=94|year=2015|last1=Khan|first1=Mushfiquddin|last2=Shunmugavel|first2=Anandakumar|last3=Dhammu|first3=Tajinder S|last4=Matsuda|first4=Fumiyo|last5=Singh|first5=Avtar K|last6=Singh|first6=Inderjit}} 3. ^{{cite journal | doi=10.1089/neu.2008-0835 | title=Arachidonyl trifluoromethyl ketone is neuroprotective after spinal cord injury | journal=Journal of Neurotrauma | pages=110306202455053 | year=2009 | last1=Huang | first1=Wenlong | last2=Bhavsar | first2=Amar | last3=Ward | first3=Rachael E | last4=Hall | first4=Jodie C.E. | last5=Priestley | first5=John V. | last6=Michael-Titus | first6=Adina T. }} 4. ^{{cite journal |doi=10.1016/j.expneurol.2011.05.014|pmid=21683698|title=Arachidonyl trifluoromethyl ketone ameliorates experimental autoimmune encephalomyelitis via blocking peroxynitrite formation in mouse spinal cord white matter|journal=Experimental Neurology|volume=231|issue=1|pages=45–55|year=2011|last1=Vana|first1=Adam C.|last2=Li|first2=Shihe|last3=Ribeiro|first3=Rachel|last4=Tchantchou|first4=Flaubert|last5=Zhang|first5=Yumin}} 2 : Ketones|Trifluoromethyl compounds |
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