“Arie Lev Gruzman”的意思、由来-开放百科全书

Arie Lev Gruzman ({{lang-he|אריה גרוזמן}}; born 3 October 1970) is a Professor of Chemistry at Bar Ilan University specializing in Medicinal Chemistry.

Biography

Arie Lev Gruzman^[1] (1970) was born in Gorky (nowadays Nizhniy Novgorod), Russia. He graduated (1988) from {{ill|First Gorky Nursing College|ru|Нижегородский медицинский базовый колледж|vertical-align=sup}}^[2] (Summa cum Laude) as a practical nurse. At the same year, he enrolled at the Pediatric faculty of Gorky Academy for Medicine (nowadays, Privolzhsky Research Medical University). After two and a half years, he interrupted his education towards M.D. and repatriated to Israel in 1991. He obtained his B.Sc. in Medicinal chemistry from Bar-Ilan University (1995) and a Ph.D. (Summa cum Laude) from the School of Pharmacy,^[3] Faculty of Medicine, at the Hebrew University of Jerusalem under the supervision of Prof. Shlomo Sasson and Prof. Jehoshua Katzehendler. After a military service in the IDF, he was a postdoctoral researcher (2004-2007) at the Department of Physiology, University of California, San Francisco School of Medicine (UCSF) and at California Pacific Medical Center (CPMC) at San Francisco, under the supervision of Prof. Vishvanath Lingappa.^[4] After returning to Israel, he worked as a head of a project (development of new antidiabetic drug) at Yissum Research Development Company of the Hebrew University. Since 2009 he is a Faculty member in the Department of Chemistry at Bar-Ilan University.^[5] Gruzman served as a Vice-President of the Medicinal Chemistry Section of the Israel Chemical Society MCS-ICS (2011-2015).^[6] He is also one of the founders of the startup drug development company “AltA-ZuZ”.^[7]

Scientific interests and publications

His research areas of interest^[1]^[8] include organic synthesis, medicinal chemistry, peptide chemistry, analytical chemistry, pharmacology, pharmacokinetics studies, in vitro and in vivo drug candidate testing, nanotechnology, molecular computer-aided modeling, and basic biochemistry. His current research^[9] focuses on developing of new drugs for the treatment of insulin dependent diabetes mellitus (IDDM, Type 1 diabetes)^[10] and non-insulin dependent diabetes mellitus (NIDDM, Type 2 diabetes) type of diabetes.^[11]^[12]^[13] His group, together with collaborators, developed several compounds that have a bi-functional mode of action in NIDDM. Such drug candidates increase the rate of glucose uptake in skeletal muscles and augment the rate of insulin secretion.^[14]^[15] Gruzman’s group also developed new drug candidates against ALS.^[16]^[17]^[18] His chemistry expertise is mainly related to peptide/peptidomimetic chemistry.^[19]^[20]

Among his awards is Excellence in teaching^[23] (2016); “Faculty of 1000 Biology Award” (2007);^[24] The Kaye Innovation Awards at the Hebrew University of Jerusalem (2003);^[25] Bern-Schlander Research Award, the Diabetes Research Centre of the Hebrew University of Jerusalem (2002).

Personal life

Arie Lev Gruzman is married to Evgenia Alpert, M.D., Ph.D., who serves as the Director of Biology at “Ayala Targeted Therapies”, Rehovot.^[26] They live in Tzur Hadassah and have two children.

References

1. ^¹[https://ch.biu.ac.il/gruzman Prof. Arie-Lev Gruzman, Bar-Ilan University]
2. ^Nowadays, ({{lang-ru|:Нижегородский медицинский базовый колледж}})
3. ^[https://medicine.ekmd.huji.ac.il/schools/pharmacy/En/home/Pages/default.aspx School of Pharmacy, The Hebrew University of Jerusalem]
4. ^[https://www.the-asci.org/controllers/asci/AsciProfileController.php?pid=159600 Vishwanath Rao Lingappa - The American Society for Clinical Investigation]
5. ^[https://ch.biu.ac.il/ Department of Chemistry, Bar-Ilan University]
6. ^MCS-ICS Medicinal Chemistry Section of the Israel Chemical Society
7. ^[https://www.linkedin.com/company/alta-zuz-therapeutics AltA-ZuZ Therapeutics]
8. ^[https://www.gruzman-lab.com/ Prof. Gruzman's lab - website]
9. ^[https://www.gruzman-lab.com/publications Prof. Arie-Lev Gruzman - List of Publications]
10. ^{{cite journal|last1=Munder|first1=Anna|last2=Israel|first2=Liron L.|last3=Kahremany|first3=Shirin|last4=Ben-Shabat-Binyamini|first4=Rina|last5=Zhang|first5=Charles|last6=Kolitz-Domb|first6=Michal|last7=Viskind|first7=Olga|last8=Levine|first8=Anna|last9=Senderowitz|first9=Hanoch|last10=Chessler|first10=Steven|last11=Lellouche|first11=Jean-Paul|last12=Gruzman|first12=Arie|title=Mimicking Neuroligin-2 Functions in β-Cells by Functionalized Nanoparticles as a Novel Approach for Antidiabetic Therapy|journal=ACS Applied Materials & Interfaces|volume=9|issue=2|year=2017|pages=1189–1206|issn=1944-8244|doi=10.1021/acsami.6b10568}}
11. ^{{cite journal|last1=Gruzman|first1=Arie|last2=Hidmi|first2=Adel|last3=Katzhendler|first3=Jehoshua|last4=Haj-Yehie|first4=Abdalla|last5=Sasson|first5=Shlomo|title=Synthesis and characterization of new and potent α-lipoic acid derivatives|journal=Bioorganic & Medicinal Chemistry|volume=12|issue=5|year=2004|pages=1183–1190|issn=0968-0896|doi=10.1016/j.bmc.2003.11.025}}
12. ^{{cite journal|last1=Gruzman|first1=Arie|last2=Shamni|first2=Ofer|last3=Ben Yakir|first3=Moriya|last4=Sandovski|first4=Daphna|last5=Elgart|first5=Anna|last6=Alpert|first6=Evgenia|last7=Cohen|first7=Guy|last8=Hoffman|first8=Amnon|last9=Katzhendler|first9=Yehoshua|last10=Cerasi|first10=Erol|last11=Sasson|first11=Shlomo|title=Noveld-Xylose Derivatives Stimulate Muscle Glucose Uptake by Activating AMP-Activated Protein Kinase α|journal=Journal of Medicinal Chemistry|volume=51|issue=24|year=2008|pages=8096–8108|issn=0022-2623|doi=10.1021/jm8008713}}
13. ^{{cite journal|last1=Meltzer-Mats|first1=Ella|last2=Babai-Shani|first2=Gali|last3=Pasternak|first3=Lily|last4=Uritsky|first4=Neta|last5=Getter|first5=Tamar|last6=Viskind|first6=Olga|last7=Eckel|first7=Jürgen|last8=Cerasi|first8=Erol|last9=Senderowitz|first9=Hanoch|last10=Sasson|first10=Shlomo|last11=Gruzman|first11=Arie|title=Synthesis and Mechanism of Hypoglycemic Activity of Benzothiazole Derivatives|journal=Journal of Medicinal Chemistry|volume=56|issue=13|year=2013|pages=5335–5350|issn=0022-2623|doi=10.1021/jm4001488}}
14. ^{{cite journal|last1=Pasternak|first1=L.|last2=Meltzer-Mats|first2=E.|last3=Babai-Shani|first3=G.|last4=Cohen|first4=G.|last5=Viskind|first5=O.|last6=Eckel|first6=J.|last7=Cerasi|first7=E.|last8=Sasson|first8=S.|last9=Gruzman|first9=A.|title=Benzothiazole derivatives augment glucose uptake in skeletal muscle cells and stimulate insulin secretion from pancreatic β-cells via AMPK activation|journal=Chem. Commun.|volume=50|issue=76|year=2014|pages=11222–11225|issn=1359-7345|doi=10.1039/C4CC03310H}}
15. ^{{cite journal|last1=Rozentul|first1=Naomi|last2=Avrahami|first2=Yosef|last3=Shubely|first3=Moran|last4=Levy|first4=Laura|last5=Munder|first5=Anna|last6=Cohen|first6=Guy|last7=Cerasi|first7=Erol|last8=Sasson|first8=Shlomo|last9=Gruzman|first9=Arie|title=A Novel Phenylchromane Derivative Increases the Rate of Glucose Uptake in L6 Myotubes and Augments Insulin Secretion from Pancreatic Beta-Cells by Activating AMPK|journal=Pharmaceutical Research|volume=34|issue=12|year=2017|pages=2873–2890|issn=0724-8741|doi=10.1007/s11095-017-2271-7}}
16. ^{{cite journal|last1=Gruzman|first1=A.|last2=Wood|first2=W. L.|last3=Alpert|first3=E.|last4=Prasad|first4=M. D.|last5=Miller|first5=R. G.|last6=Rothstein|first6=J. D.|last7=Bowser|first7=R.|last8=Hamilton|first8=R.|last9=Wood|first9=T. D.|last10=Cleveland|first10=D. W.|last11=Lingappa|first11=V. R.|last12=Liu|first12=J.|title=Common molecular signature in SOD1 for both sporadic and familial amyotrophic lateral sclerosis|journal=Proceedings of the National Academy of Sciences|volume=104|issue=30|year=2007|pages=12524–12529|issn=0027-8424|doi=10.1073/pnas.0705044104}}
17. ^{{cite journal|last1=Daniel|first1=Bareket|last2=Green|first2=Omer|last3=Viskind|first3=Olga|last4=Gruzman|first4=Arie|title=Riluzole increases the rate of glucose transport in L6 myotubes and NSC-34 motor neuron-like cells via AMPK pathway activation|journal=Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration|volume=14|issue=5-6|year=2013|pages=434–443|issn=2167-8421|doi=10.3109/21678421.2013.808226}}
18. ^{{cite journal|last1=Getter|first1=Tamar|last2=Zaks|first2=Ilana|last3=Barhum|first3=Yael|last4=Ben-Zur|first4=Tali|last5=Böselt|first5=Sebastian|last6=Gregoire|first6=Simpson|last7=Viskind|first7=Olga|last8=Shani|first8=Tom|last9=Gottlieb|first9=Hugo|last10=Green|first10=Omer|last11=Shubely|first11=Moran|last12=Senderowitz|first12=Hanoch|last13=Israelson|first13=Adrian|last14=Kwon|first14=Inchan|last15=Petri|first15=Susanne|last16=Offen|first16=Daniel|last17=Gruzman|first17=Arie|title=A Chemical Chaperone-Based Drug Candidate is Effective in a Mouse Model of Amyotrophic Lateral Sclerosis (ALS)|journal=ChemMedChem|volume=10|issue=5|year=2015|pages=850–861|issn=1860-7179|doi=10.1002/cmdc.201500045}}
19. ^{{cite journal|last1=Shapira|first1=Renana|last2=Rudnick|first2=Safra|last3=Daniel|first3=Bareket|last4=Viskind|first4=Olga|last5=Aisha|first5=Vered|last6=Richman|first6=Michal|last7=Ayasolla|first7=Kamesh R.|last8=Perelman|first8=Alex|last9=Chill|first9=Jordan H.|last10=Gruzman|first10=Arie|last11=Rahimipour|first11=Shai|title=Multifunctional Cyclic d,l-α-Peptide Architectures Stimulate Non-Insulin Dependent Glucose Uptake in Skeletal Muscle Cells and Protect Them Against Oxidative Stress|journal=Journal of Medicinal Chemistry|volume=56|issue=17|year=2013|pages=6709–6718|issn=0022-2623|doi=10.1021/jm4005225}}
20. ^{{cite journal|last1=Trifonov|first1=Lena|last2=Afri|first2=Michal|last3=Palczewski|first3=Krzysztof|last4=Korshin|first4=Edward E.|last5=Gruzman|first5=Arie|title=An Expedient Synthesis of CMF-019: (S)-5-Methyl-3-({)1-(pentan-3-yl)-2- (thiophen-2-ylmethyl)-1H-benzo[d]imidazole-5-carboxamido)hexanoic Acid, a Potent Apelin Receptor (APJ) Agonist|journal=Medicinal Chemistry|volume=14|issue=7|year=2018|pages=688–694|issn=15734064|doi=10.2174/1573406414666180412154952}}
21. ^{{cite journal|last1=Kahremany|first1=Shirin|last2=Babaev|first2=Ilana|last3=Hasin|first3=Pinhas|last4=Tamir|first4=Tigist Y.|last5=Ben-Zur|first5=Tali|last6=Cohen|first6=Guy|last7=Jiang|first7=Zhengyu|last8=Weintraub|first8=Sagiv|last9=Offen|first9=Daniel|last10=Rahimipour|first10=Shai|last11=Major|first11=M. Ben|last12=Senderowitz|first12=Hanoch|last13=Gruzman|first13=Arie|title=Computer-Aided Design and Synthesis of 14-[(3,4-Dihydroxybenzylidene)amino]phenyl5-oxopyrrolidine-3-carboxylic Acid as an Nrf2 Enhancer|journal=ChemPlusChem|volume=83|issue=5|year=2018|pages=320–333|issn=2192-6506|doi=10.1002/cplu.201700539}}
22. ^{{cite journal|last1=Kahremany|first1=Shirin|last2=Zhenin|first2=Michael|last3=Shenberger|first3=Yulia|last4=Maimoun|first4=David|last5=Colotti|first5=Gianni|last6=Arad|first6=Michael|last7=Shainberg|first7=Asher|last8=Senderowitz|first8=Hanoch|last9=Ruthstein|first9=Sharon|last10=Gruzman|first10=Arie|title=Peptide-based development of PKA activators|journal=New Journal of Chemistry|volume=42|issue=23|year=2018|pages=18585–18597|issn=1144-0546|doi=10.1039/C8NJ01732H}}
23. ^[https://www1.biu.ac.il/index.php?id=16932&pt=1&pid=11240&level=0&cPath=5,25,1692,11240,16932 Bar-Ilan University Excellence in Teaching, 2016]
24. ^[https://f1000.com/prime/1089533# F1000 website]
25. ^[https://new.huji.ac.il/en/taxonomy/term/453 The Kaye Innovation Awards, Hebrew University of Jerusalem]
26. ^[https://www.ayalapharma.com/ Ayala targeted therapies]