| 词条 | Artesunate/pyronaridine |
| 释义 |
| Verifiedfields = | Watchedfields = | verifiedrevid = | drug_name = | image = | width = | type = combo | component1 = Artesunate | class1 = Antimalarial | component2 = Pyronaridine | class2 = Antimalarial | synonyms = Artesunate/pyronaridine tetraphosphate[1] | tradename = Pyramax[1] | Drugs.com = | MedlinePlus = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = By mouth[3] | CAS_number_Ref = | CAS_number = | ATC_prefix = P01 | ATC_suffix = BF06 | PubChem = | DrugBank_Ref = | DrugBank = | NIAID_ChemDB = }}Artesunate/pyronaridine, sold under the brand name Pyramax, is a fixed dose combination medication for the treatment of malaria.[4][1] It can be used for malaria of both the P. falciparum and P. vivax types.[1] It combines artesunate and pyronaridine.[4] It is taken by mouth.[1] The combination is generally well tolerated.[1] Side effects may include headache, vomiting, or cough.[1] Use in those with severe liver disease or kidney disease is not recommended.[1] Use is not generally recommended in early pregnancy.[1] However, there are no other options and if treatment may save the mother's life it may be used.[1] The two components work by different mechanisms.[1] It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system.[2] In 2010 the wholesale cost of a course of treatment in the developing world was between 0.55 and 2.18 USD.[3] Medical usesArtesunate/pyronaridine is used for malaria of both the P. falciparum and P. vivax types.[3] It is not recommended for severe disease.[1] A 2014 review found that the combination compared well to artemether/lumefantrine.[4]{{Update inline|reason=Updated version https://www.ncbi.nlm.nih.gov/pubmed/30620055|date = March 2019}} Benefits also appear similar to mefloquine together with artesunate.[4] It is not recommended for the prevention of malaria.[1] References1. ^1 2 3 4 5 6 7 {{cite web|title=Pyramax 180 mg/60 mg Film-coated tablet|url=http://www.ema.europa.eu/docs/en_GB/document_library/Medicine_for_use_outside_EU/2012/06/WC500129288.pdf|website=EMA|accessdate=13 December 2017}} {{portal bar|Pharmacy and pharmacology|Medicine}}2. ^1 2 {{cite web|title=WHO Model List of Essential Medicines (20th List)|url=http://www.who.int/medicines/publications/essentialmedicines/20th_EML2017.pdf?ua=1|work=World Health Organization|accessdate=29 June 2017|date=March 2017}} 3. ^1 2 3 4 5 6 7 {{cite web|title=Application for inclusion in the WHO Model List of essential medicines|url=http://www.who.int/selection_medicines/committees/expert/18/applications/pyronaridine_artesunate_application.pdf?ua=1|website=WHO|accessdate=29 June 2017|date=Nov 2010}} 4. ^1 {{cite journal|last1=Bukirwa|first1=H|last2=Unnikrishnan|first2=B|last3=Kramer|first3=CV|last4=Sinclair|first4=D|last5=Nair|first5=S|last6=Tharyan|first6=P|title=Artesunate plus pyronaridine for treating uncomplicated Plasmodium falciparum malaria.|journal=The Cochrane Database of Systematic Reviews|date=4 March 2014|issue=3|pages=CD006404|doi=10.1002/14651858.CD006404.pub2|pmid=24596021|pmc=4448218}} 2 : World Health Organization essential medicines|RTT |
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