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词条 Asad Ullah Khan
释义

  1. Biography

  2. Professional profile

  3. Awards and honors

  4. Selected bibliography

  5. See also

  6. Notes

  7. References

  8. Further reading

  9. External links

{{Use dmy dates|date=May 2018}}{{Use Indian English|date=May 2018}}{{Infobox scientist
| name = Asad Ullah Khan
| image =
| alt =
| caption =
| birth_date =
| birth_place = India
| death_date =
| death_place =
| residence = Aligarh, Uttar Pradesh, India
| nationality = Indian
| fields = {{ublist | Biochemistry | Microbiology }}
| workplaces = {{ublist | Aligarh Muslim University }}
| alma_mater = {{ublist | Aligarh Muslim University | International Centre for Genetic Engineering and Biotechnology | Rutgers University }}
| doctoral_advisor =
| doctoral_students =
| known_for = Discovery of Aligarh super bug in India
| awards = {{ublist| 2006 AMI Young Scientist Award | 2009  AMI-ALEMBIC Award | 2010 AMU Active Teacher Award | 2011 DBT CREST Award | 2012 N-BIOS Prize | 2014 AMU Outstanding Research Award }}
}}

Asad Ullah Khan is an Indian microbiologist, biochemist and a professor at the Interdisciplinary Biotechnology Unit of the Aligarh Muslim University. He is known for his studies on multidrug resistant clinical strains as well as for the first sighting in India of Aligarh super bug (NDM-4), a variant of New Delhi metallo-beta-lactamase 1 (NDM-1). He is an elected fellow of the Royal Society of Chemistry, the Biotech Research Society, India and the Indian Academy of Microbiological Sciences. The Department of Biotechnology of the Government of India awarded him the National Bioscience Award for Career Development, one of the highest Indian science awards, for his contributions to biosciences, in 2012.

Biography

Dr. Asad Ullah Khan did his undergraduate studies in chemistry and post-graduate studies in biotechnology at the Aligarh Muslim University (AMU) after which he pursued his doctoral studies at the International Centre for Genetic Engineering and Biotechnology, New Delhi to secure a PhD in biochemistry from Aligarh Muslim University.[1] He started his career as a lecturer at AMU in 1997 and during his career there, he did his post-doctoral studies at Rutgers University during 2000–03. He returned to India to resume his career at AMU where he holds the position of a professor and the coordinator of the Biotechnology Unit.[2]

Professional profile

Khan's research focus is on developing new inhibitors against multidrug resistant clinical strains with special interest on extended spectrum beta lactamases (ESBL) such as NDM-1 and CTX-M, using QSARR modeling and structure-based virtual screening methods.[1] The team led by him collect Escherichia coli and Klebsiella pneumonia strains from hospital and community-acquired infection sites and it was during one of those explorations that he discovered a variant of New Delhi metallo-beta-lactamase 1 named NDM-4, more commonly known as Aligarh super bug, in the sewage drains of Jawaharlal Nehru Medical College, Aligarh, in 2014.[3] This was the first recorded sighting of the antibiotic-resistant super bug in India;{{Refn|group=note|New Delhi metallo-beta-lactamase 1 was the first in the series of NDM super bugs and was detected in a Swedish patient in New Dehi in 2009,[4]}}[5][6] the finding was later disclosed by Khan in an article published in the Journal of Medical Microbiology.[7] Later, Khan and his colleagues developed a protocol for detecting super bugs and was successful in sequencing the genes of three variants of NDM-1.[8] His studies have been documented by way of a number of articles[9]{{Refn|group=note|Please see Selected bibliography section}} and ResearchGate, an online repository of scientific articles has listed 241 of them.[10] Besides he has also edited three books.[2]

Khan is a member of the scientific committee of the Indian Academy of Biomedical Sciences[11] and sits in the advisory board of the Sir Syed Global Scholar Award (SSGSA) committee.[12] He is an associate editor of BMC Microbiology for their section on Clinical microbiology and vaccines[13] and is a member of the Task Force on Bioinformatics, Computational and Systems Biology of the Department of Biotechnology.[2] He has also conducted workshops and seminars on the subject.[14]

Awards and honors

The Association of Microbiologists of India (AMI) awarded Khan the Young Scientist Award in 2006;[2] AMI honored him again in 2009 with the Alembic Award.[15][16] He received the Most Active Teacher Award from Aligarh Muslim University in 2010[17] and the Cutting-Edge Research Enhancement and Scientific Training (CREST) Award of the Department of Biotechnology in 2011.[2] The Department of Biotechnology (DBT) of the Government of India awarded him the National Bioscience Award for Career Development, one of the highest Indian science awards in 2012.[18] When Aligarh Muslim University instituted the Outstanding Research Award in 2014, he was the first recipient of the award.[19]

Khan was elected as a fellow by the Royal Society of Chemistry in 2017.[20] He is also an elected fellow of the Biotech Research Society, India[21] and the Indian Academy of Microbiological Sciences[22] and the various research fellowships he has received include University Grants Commission fellowship (1995–98), Boyscast fellowship of the Department of Science and Technology (2004–05) and the visiting fellowship of the Indian National Science Academy (2006–07).[19]

Selected bibliography

  • {{cite journal |doi=10.3389/fimmu.2017.01552 |pmid=29181009 |pmc=5694031 |title=CRISPRi Induced Suppression of Fimbriae Gene (fimH) of a Uropathogenic Escherichia coli: An Approach to Inhibit Microbial Biofilms |journal=Frontiers in Immunology |volume=8 |pages=1552 |year=2017 |last1=Zuberi |first1=Azna |last2=Ahmad |first2=Nayeem |last3=Khan |first3=Asad U }}
  • {{cite journal |doi=10.1038/s41598-017-09588-1 |pmid=28835636 |pmc=5569068 |title=Potential inhibitors designed against NDM-1 type metallo-β-lactamases: An attempt to enhance efficacies of antibiotics against multi-drug-resistant bacteria |journal=Scientific Reports |volume=7 |issue=1 |pages=9207 |year=2017 |last1=Khan |first1=Asad U |last2=Ali |first2=Abid |last3=Danishuddin |last4=Srivastava |first4=Gaurava |last5=Sharma |first5=Ashok |bibcode=2017NatSR...7.9207K }}
  • {{cite journal |doi=10.1016/j.nano.2017.06.015 |pmid=28673854 |title=Nano-therapeutics: A revolution in infection control in post antibiotic era |journal=Nanomedicine: Nanotechnology, Biology and Medicine |volume=13 |issue=7 |pages=2281–2301 |year=2017 |last1=Zaidi |first1=Sahar |last2=Misba |first2=Lama |last3=Khan |first3=Asad U }}
  • {{cite journal |doi=10.3389/fcimb.2017.00214 |pmid=28603699 |pmc=5445563 |title=CRISPR Interference (CRISPRi) Inhibition of luxS Gene Expression in E. Coli: An Approach to Inhibit Biofilm |journal=Frontiers in Cellular and Infection Microbiology |volume=7 |pages=214 |year=2017 |last1=Zuberi |first1=Azna |last2=Misba |first2=Lama |last3=Khan |first3=Asad U }}
  • {{cite journal |doi=10.1016/j.ijantimicag.2016.10.001 |pmid=28244375 |title=First reported New Delhi metallo-β-lactamase-1-producing Cedecea lapagei |journal=International Journal of Antimicrobial Agents |volume=49 |issue=1 |pages=118–119 |year=2017 |last1=Ahmad |first1=Nayeem |last2=Ali |first2=Syed Manazir |last3=Khan |first3=Asad U }}
  • {{cite journal |doi=10.1016/S1473-3099(15)00424-7 |pmid=26603172 |title=Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: A microbiological and molecular biological study |journal=The Lancet Infectious Diseases |volume=16 |issue=2 |pages=161–168 |year=2016 |last1=Liu |first1=Yi-Yun |last2=Wang |first2=Yang |last3=Walsh |first3=Timothy R |last4=Yi |first4=Ling-Xian |last5=Zhang |first5=Rong |last6=Spencer |first6=James |last7=Doi |first7=Yohei |last8=Tian |first8=Guobao |last9=Dong |first9=Baolei |last10=Huang |first10=Xianhui |last11=Yu |first11=Lin-Feng |last12=Gu |first12=Danxia |last13=Ren |first13=Hongwei |last14=Chen |first14=Xiaojie |last15=Lv |first15=Luchao |last16=He |first16=Dandan |last17=Zhou |first17=Hongwei |last18=Liang |first18=Zisen |last19=Liu |first19=Jian-Hua |last20=Shen |first20=Jianzhong }}
  • {{cite journal |doi=10.1016/j.drudis.2016.06.013 |pmid=27326911 |title=Descriptors and their selection methods in QSAR analysis: Paradigm for drug design |journal=Drug Discovery Today |volume=21 |issue=8 |pages=1291–1302 |year=2016 |last1=Danishuddin |last2=Khan |first2=Asad U }}
  • {{cite journal |doi=10.1128/AAC.01194-15 |pmid=26525789 |title=Role of Non-Active-Site Residue Trp-93 in the Function and Stability of New Delhi Metallo-β-Lactamase 1 |journal=Antimicrobial Agents and Chemotherapy |volume=60 |issue=1 |pages=356–360 |year=2016 |last1=Khan |first1=Asad U |last2=Rehman |first2=M. Tabish |pmc=4704196 }}
  • {{cite journal |doi=10.3389/fmicb.2016.00174 |pmid=26925046 |pmc=4757689 |title=Breaking the Spell: Combating Multidrug Resistant 'Superbugs' |journal=Frontiers in Microbiology |volume=7 |pages=174 |year=2016 |last1=Khan |first1=Shahper N |last2=Khan |first2=Asad U }}
  • {{cite journal |doi=10.1021/mp500116c |pmid=24745377 |title=Insight into the Binding Mechanism of Imipenem to Human Serum Albumin by Spectroscopic and Computational Approaches |journal=Molecular Pharmaceutics |volume=11 |issue=6 |pages=1785–1797 |year=2014 |last1=Rehman |first1=Md Tabish |last2=Shamsi |first2=Hira |last3=Khan |first3=Asad U }}
  • {{cite journal |doi=10.1186/s12866-014-0320-5 |pmid=25591663 |pmc=4316655 |title=Inhibitory effect of zingiber officinale towards Streptococcus mutans virulence and caries development: In vitro and in vivo studies |journal=BMC Microbiology |volume=15 |pages=1 |year=2015 |last1=Hasan |first1=Sadaf |last2=Danishuddin |first2=Mohd |last3=Khan |first3=Asad U }}
  • {{cite journal |doi=10.1016/j.ymeth.2014.10.019 |pmid=25448480 |title=Structure based virtual screening to discover putative drug candidates: Necessary considerations and successful case studies |journal=Methods |volume=71 |pages=135–145 |year=2015 |last1=Danishuddin |first1=Mohd |last2=Khan |first2=Asad U }}
  • {{cite journal |doi=10.1186/s12866-014-0320-5|pmid=25591663|pmc=4316655|title=Inhibitory effect of zingiber officinale towards Streptococcus mutans virulence and caries development: In vitro and in vivo studies|journal=BMC Microbiology|volume=15|pages=1|year=2015|last1=Hasan|first1=Sadaf|last2=Danishuddin|first2=Mohd|last3=Khan|first3=Asad U}}
  • {{cite journal |doi=10.1080/08927014.2014.983093 |pmid=25431994 |title=A graphene/zinc oxide nanocomposite film protects dental implant surfaces against cariogenic Streptococcus mutans |journal=Biofouling |volume=30 |issue=10 |pages=1281–1294 |year=2014 |last1=Kulshrestha |first1=Shatavari |last2=Khan |first2=Shakir |last3=Meena |first3=Ramovatar |last4=Singh |first4=Braj R |last5=Khan |first5=Asad U }}
  • {{cite journal |doi=10.2147/IJN.S31219 |pmid=22802686 |pmc=3396389 |title=Gold nanoparticles enhance methylene blue– induced photodynamic therapy: A novel therapeutic approach to inhibit Candida albicans biofilm |journal=International Journal of Nanomedicine |volume=7 |pages=3245–57 |year=2012 |last1=Khan |first1=Asad |last2=Khan |last3=Azam |last4=Alam }}
  • {{cite journal |doi=10.1371/journal.pone.0091736 |pmid=24622055 |pmc=3951425 |title=Inhibition of Major Virulence Pathways of Streptococcus mutans by Quercitrin and Deoxynojirimycin: A Synergistic Approach of Infection Control |journal=PLOS ONE |volume=9 |issue=3 |pages=e91736 |year=2014 |last1=Hasan |first1=Sadaf |last2=Singh |first2=Kunal |last3=Danisuddin |first3=Mohd |last4=Verma |first4=Praveen K |last5=Khan |first5=Asad U |bibcode=2014PLoSO...991736H }}
  • {{cite journal |doi=10.1371/journal.pone.0056926 |pmid=23437273 |pmc=3578935 |title=Biochemical Characterization of CTX-M-15 from Enterobacter cloacae and Designing a Novel Non-β-Lactam-β-Lactamase Inhibitor |journal=PLOS ONE |volume=8 |issue=2 |pages=e56926 |year=2013 |last1=Faheem |first1=Mohammad |last2=Rehman |first2=Md Tabish |last3=Danishuddin |first3=Mohd |last4=Khan |first4=Asad U |bibcode=2013PLoSO...856926F }}
  • {{cite journal |doi=10.1371/journal.pone.0051850 |pmid=23251640 |pmc=3522591 |title=Inhibition of N-Terminal Lysines Acetylation and Transcription Factor Assembly by Epirubicin Induced Deranged Cell Homeostasis |journal=PLOS ONE |volume=7 |issue=12 |pages=e51850 |year=2012 |last1=Khan |first1=Shahper N |last2=Danishuddin |first2=Mohd |last3=Varshney |first3=Bhavna |last4=Lal |first4=Sunil K |last5=Khan |first5=Asad U |bibcode=2012PLoSO...751850K }}
  • {{cite journal |doi=10.1093/jac/dkn253 |pmid=18565974 |title=Novel anti-adherence activity of mulberry leaves: Inhibition of Streptococcus mutans biofilm by 1-deoxynojirimycin isolated from Morus alba |journal=Journal of Antimicrobial Chemotherapy |volume=62 |issue=4 |pages=751–757 |year=2008 |last1=Islam |first1=B |last2=Khan |first2=S. N |last3=Haque |first3=I |last4=Alam |first4=M |last5=Mushfiq |first5=M |last6=Khan |first6=A. U }}
  • {{cite journal |doi=10.1128/AAC.00366-08 |pmid=18725447 |pmc=2573143 |title=A Plasmid-Borne blaOXA-58 Gene Confers Imipenem Resistance to Acinetobacter baumannii Isolates from a Lebanese Hospital |journal=Antimicrobial Agents and Chemotherapy |volume=52 |issue=11 |pages=4115–4120 |year=2008 |last1=Zarrilli |first1=R |last2=Vitale |first2=D |last3=Di Popolo |first3=A |last4=Bagattini |first4=M |last5=Daoud |first5=Z |last6=Khan |first6=A. U |last7=Afif |first7=C |last8=Triassi |first8=M }}
  • {{cite journal |doi=10.1101/gad.1075203 |pmid=12704082 |pmc=196040 |title=Functional interactions between the transcription and mRNA 3' end processing machineries mediated by Ssu72 and Sub1 |journal=Genes & Development |volume=17 |issue=8 |pages=1030–1042 |year=2003 |last1=He |first1=X }}
  • {{cite journal |doi=10.1016/S0168-9525(02)02746-4 |title=Connecting the DOTs: Covalent histone modifications and the formation of silent chromatin |journal=Trends in Genetics |volume=18 |issue=8 |pages=387–389 |year=2002 |last1=Khan |first1=Asad U |last2=Hampsey |first2=Michael }}

See also

{{Div col|colwidth=30em}}
  • New Delhi metallo-beta-lactamase 1
  • Common multidrug-resistant organisms (MDROs)
{{Div col end}}{{portal|India|Biology|Medicine}}

Notes

1. ^{{Cite web |url=http://www.drasadlab.in/ |title=Asad U Khan Lab |date=2018-01-30 |website=Aligarh Muslim University India |language=en |access-date=2018-01-30}}
2. ^{{Cite web |url=https://www.amu.ac.in/dshowfacultydata.jsp?did=47&eid=10057753 |title=Aligarh Muslim University - Department Page |date=2018-01-30 |website=www.amu.ac.in |language=en |access-date=2018-01-30}}
3. ^{{Cite news |url=http://www.livemint.com/Politics/F9cXdam9j36xhzkegjZF3L/Why-India-should-be-worried-about-the-Aligarh-superbug.html |title=Why India should be worried about the Aligarh superbug |last=Krishnan |first=Vidya |date=2014-10-02 |work=Live Mint |access-date=2018-01-31}}
4. ^{{Cite journal |last=Yong |first=Dongeun |last2=Toleman |first2=Mark A. |last3=Giske |first3=Christian G. |last4=Cho |first4=Hyun S. |last5=Sundman |first5=Kristina |last6=Lee |first6=Kyungwon |last7=Walsh |first7=Timothy R. |date=2009-12-01 |title=Characterization of a New Metallo-β-Lactamase Gene, blaNDM-1, and a Novel Erythromycin Esterase Gene Carried on a Unique Genetic Structure in Klebsiella pneumoniae Sequence Type 14 from India |url=http://aac.asm.org/content/53/12/5046 |journal=Antimicrobial Agents and Chemotherapy |language=en |volume=53 |issue=12 |pages=5046–5054 |doi=10.1128/aac.00774-09 |issn=0066-4804 |pmid=19770275}}
5. ^{{Cite news |url=https://timesofindia.indiatimes.com/city/agra/New-superbug-found-in-Aligarh-hospital-drain/articleshow/41811189.cms |title=New ‘superbug’ found in Aligarh hospital drain - Times of India |date=5 September 2014 |work=The Times of India |access-date=2018-01-31}}
6. ^{{Cite news |url=https://www.ndtv.com/india-news/antibiotic-resistant-super-bug-found-at-aligarh-muslim-university-658368 |title=Antibiotic Resistant 'Super Bug' Found at Aligarh Muslim University |date=3 September 2014 |work=NDTV.com |access-date=2018-01-31}}
7. ^{{Cite news |url=http://www.livemint.com/Politics/pBn6OceiarcL5LAy6HyweO/Antibiotic-resistant-super-bug-found-at-Aligarh-Muslim-Uni.html |title=Antibiotic resistant ‘superbug’ found at Aligarh medical college |last=PTI |date=2014-09-03 |work=Live Mint |access-date=2018-01-31}}
8. ^{{Cite news |url=http://www.thehindu.com/todays-paper/tp-national/tp-newdelhi/amu-scientists-develop-technique-to-detect-superbug/article2092742.ece |title=AMU scientists ‘develop' technique to detect superbug |date=2011-06-10 |work=The Hindu |access-date=2018-01-31 |language=en-IN |issn=0971-751X}}
9. ^{{Cite web |url=https://scholar.google.co.in/citations?user=h5isISAAAAAJ |title=On Google Scholar |date=2018-01-30 |publisher=Google Scholar |access-date=2018-01-30}}
10. ^{{Cite web |url=https://www.researchgate.net/profile/Asad_Khan17 |title=On ResearchGate |date=2018-01-30 |publisher=On ResearchGate |access-date=2018-01-30}}
11. ^{{Cite web |url=http://iabs.in/conf-alig-14-15-dec.2013.htm |title=Welcome to :: Indian Academy of Biomedical Sciences (IABS) - Uttar Pradesh, India |date=2018-01-30 |website=iabs.in |access-date=2018-01-30 |archive-url=https://web.archive.org/web/20170608061513/http://iabs.in/conf-alig-14-15-dec.2013.htm |archive-date=8 June 2017 |dead-url=yes |df=dmy-all }}
12. ^{{Cite web |url=http://www.ssgsa.us/members.php |title=Sir Syed Global Scholar Award (SSESA) |date=2018-01-30 |website=www.ssgsa.us |access-date=2018-01-30}}
13. ^{{Cite web |url=https://bmcmicrobiol.biomedcentral.com/about/editorial-board |title=BMC Microbiology |date=2018-01-31 |website=BMC Microbiology |language=en |access-date=2018-01-31}}
14. ^{{Cite web |url=http://myamu.in/news/centre-sophisticated-instruments-facility-amu-organises-workshop-flow-cytometry-and-its |title=Centre For Sophisticated Instruments Facility AMU Organises Workshop On Flow Cytometry and Its Applications |date=2018-01-31 |website=myamu.in |language=en |access-date=2018-01-31}}
15. ^{{Cite web |url=http://www.amiindia.info/awardees.php |title=Awardees - Association of Microbiologists of India |date=2018-01-31 |website=www.amiindia.info |language=en |access-date=2018-01-31}}
16. ^{{Cite web |url=http://amunewsandviews.blogspot.ae/2009/12/dr-asadullah-khan-awarded-ami-alembic.html |title=Dr Asadullah Khan Awarded AMI-ALEMBIC Award of 2009 |date=2018-01-31 |website=amunewsandviews.blogspot.ae |access-date=2018-01-31}}
17. ^{{Cite web |url=http://www.ummid.com/news/2010/January/27.01.2010/amu_vc_awards_distinguished_faculties.htm |title=Distinguished AMU research scholars, teachers and students honored |last=Reporter |first=ummid.com Staff |website=www.ummid.com |access-date=2018-01-31}}
18. ^{{Cite web |url=http://dbtindia.nic.in/wp-content/uploads/2014/03/list_of_bioscience_awardees.pdf |title=Awardees of National Bioscience Awards for Career Development |date=2016 |publisher=Department of Biotechnology |access-date=2017-11-20}}
19. ^{{Cite web |url=http://www.drasadlab.in/credentials/awards |title=National Fellowships and Awards |date=2018-01-31 |website=Interdisciplinary Biotechnology Unit Aligarh Muslim University India |language=en |access-date=2018-01-31}}
20. ^{{Cite web |url=http://twocircles.net/2017nov18/418417.html |title=AMU Faculty elected as Fellow of Royal Society of Chemistry |date=18 November 2017 |website=Two Circles |language=en-US |access-date=2018-01-31}}
21. ^{{Cite web |url=http://www.brsi.in/fellows |title=Fellows of BRSI |date=2018-01-31 |website=The Biotech Research Society, India |language=en-US |access-date=2018-01-31}}
22. ^{{Cite web |url=http://www.amiindia.info/fellows.php |title=AMI Fellows |date=2018-01-31 |website=Association of Microbiologists of India |language=en |access-date=2018-01-31}}

References

{{reflist}}

Further reading

  • {{Cite journal |last=Rahman SZ , Mishra A |title=Discovery of Aligarh Super Bug and Widespread variants of NDM1: A concern in antimicrobial resistance |url=https://www.banglajol.info/index.php/BJMS/article/viewFile/32842/22189 |journal=Bangladesh Journal of Medical Science |publication-date=3 July 2017 |volume=16 |issue=3 |pages=335–336 }}

External links

  • {{Cite web |url=http://www.educationanalysis.in/news/national-symposium-cum-bioinformatics-workshop-at-amu |title=National Symposium cum Bioinformatics Workshop at AMU |date=25 March 2015 |website=www.educationanalysis.in |language=en-US |access-date=2018-01-31 |archive-url=https://web.archive.org/web/20180131140911/http://www.educationanalysis.in/news/national-symposium-cum-bioinformatics-workshop-at-amu |archive-date=31 January 2018 |dead-url=yes |df=dmy-all }}
  • {{Cite news |url=http://www.indiatomorrow.net/eng/aligarh-scientists-discover-new-superbug |title=Aligarh scientists discover new superbug |date=6 September 2014 |work=India Tomorrow |access-date=2018-01-31}}
  • {{Cite news |url=http://www.healthcareasia.org/2014/new-strain-of-superbug-discovered-by-aligarh-researchers/ |title=New strain of superbug discovered by Aligarh researchers |date=9 September 2014 |work=Healthcare Asia |access-date=2018-01-31}}
{{N-BIOS Laureates 2010–2019}}{{authority control}}{{DEFAULTSORT:Khan, Asad Ullah}}

13 : N-BIOS Prize recipients|Indian scientific authors|Living people|21st-century Indian biologists|Indian medical researchers|Indian microbiologists|Scientists from Uttar Pradesh|Year of birth missing (living people)|Fellows of the Royal Society of Chemistry|Aligarh Muslim University alumni|Aligarh Muslim University faculty|Rutgers University alumni|Indian biochemists

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