| 词条 | Atypical SLCs | ||||||||||||||||||||||||||||||||||||
| 释义 |
Atypical MFS transport familiesMost ataypical SLCs are families within the major facilitator superfamily (MFS).[3] These atypical SLCs are plausible secondary active or facilitative transporter proteins that share ancestry with the known solute carriers.[1][2][4] They are, however, not named according to the SLC root system, or classified into any of the existing SLC families.[1] ATMFs are categorised based on their sequence similarity and phylogenetic closeness.[3]
Some Atypical SLC of MFS type are: OCA2, CLN3, SPNS1, SPNS2, SPNS3, SV2A, SV2B, SV2C, SVOP, SVOPL, MFSD1, MFSD2A, MFSD2B, MFSD3, MFSD4A,[5] MFSD4B, MFSD5, MFSD6, MFSD6L, MFSD8, MFSD9,[5] MFSD10, MFSD11, MFSD12, MFSD13A, MFSD14A, MFSD14B, UNC93A[6] and UNC93B1. All these are ataypical SLCs found within the Major facilitator superfamily. Also TMEM104 (APC clan), OCA2 (IT clan) and CLN3 (having no clan) are atypical SLCs in humans. Non-MFS transport familiesAlthough most ataypical SLCs are from the major facilitator superfamily, there are exceptions: TMEM104 (APC superfamily), OCA2 (IT superfamily) and CLN3 (unknown superfamily).[1] References1. ^1 2 3 {{Cite journal|last=Perland|first=Emelie|last2=Fredriksson|first2=Robert|date=March 2017|title=Classification Systems of Secondary Active Transporters|journal=Trends in Pharmacological Sciences|volume=38|issue=3|pages=305–315|doi=10.1016/j.tips.2016.11.008|issn=1873-3735|pmid=27939446}} {{genetics-stub}}2. ^1 {{Cite journal|last=Sreedharan|first=Smitha|last2=Stephansson|first2=Olga|last3=Schiöth|first3=Helgi B.|last4=Fredriksson|first4=Robert|date=2011-06-01|title=Long evolutionary conservation and considerable tissue specificity of several atypical solute carrier transporters|journal=Gene|volume=478|issue=1–2|pages=11–18|doi=10.1016/j.gene.2010.10.011|issn=1879-0038|pmid=21044875}} 3. ^1 {{Cite journal|last=Perland|first=Emelie|last2=Bagchi|first2=Sonchita|last3=Klaesson|first3=Axel|last4=Fredriksson|first4=Robert|date=2017-09-01|title=Characteristics of 29 novel atypical solute carriers of major facilitator superfamily type: evolutionary conservation, predicted structure and neuronal co-expression|journal=Open Biology|language=en|volume=7|issue=9|pages=170142|doi=10.1098/rsob.170142|pmid=28878041|pmc=5627054|issn=2046-2441}} 4. ^{{Cite journal|last=Höglund|first=Pär J.|last2=Nordström|first2=Karl J. V.|last3=Schiöth|first3=Helgi B.|last4=Fredriksson|first4=Robert|date=April 2011|title=The solute carrier families have a remarkably long evolutionary history with the majority of the human families present before divergence of Bilaterian species|journal=Molecular Biology and Evolution|volume=28|issue=4|pages=1531–1541|doi=10.1093/molbev/msq350|issn=1537-1719|pmc=3058773|pmid=21186191}} 5. ^1 {{Cite journal|last=Perland|first=Emelie|last2=Hellsten|first2=Sofie Victoria|last3=Schweizer|first3=Nadine|last4=Arapi|first4=Vasiliki|last5=Rezayee|first5=Fatemah|last6=Bushra|first6=Mona|last7=Fredriksson|first7=Robert|date=2017|title=Structural prediction of two novel human atypical SLC transporters, MFSD4A and MFSD9, and their neuroanatomical distribution in mice|journal=PLoS ONE|volume=12|issue=10|pages=e0186325|doi=10.1371/journal.pone.0186325|issn=1932-6203|pmid=29049335|pmc=5648162}} 6. ^{{Cite journal|last=Ceder|first=Mikaela M.|last2=Lekholm|first2=Emilia|last3=Hellsten|first3=Sofie V.|last4=Perland|first4=Emelie|last5=Fredriksson|first5=Robert|date=2017|title=The Neuronal and Peripheral Expressed Membrane-Bound UNC93A Respond to Nutrient Availability in Mice|journal=Frontiers in Molecular Neuroscience|language=English|volume=10|pages=351|doi=10.3389/fnmol.2017.00351|pmid=29163028|pmc=5671512|issn=1662-5099}} 1 : Solute carrier family |
||||||||||||||||||||||||||||||||||||
| 随便看 |
|
开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。