Wathena may refer to:

• Wathena (chief), a Native American chief of the Kickapoo tribe
• Wathena, Kansas
• USS Wathena (ID-3884), a cargo ship in commission in 1919
• USS Wathena (YTB-825), a harbor tug placed in service in 1973

• Desperate Housewives finale
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• Desperate HWA
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• Desperate (Jonas Blue song)
• Desperate Journalist
• Desperate Journalist (album)
• Desperately Seeking Stanley
• Desperately (song)
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• Desperate Man (Eric Church album)
• Desperate Man (Eric Church song)
• Desperate Man (song)
• Desperate Mission
• Desperate Mission (1965 film)
• Desperate Mission (1969 film)
• Desperate Mission (disambiguation)
• Desperate Mission (film)
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• Desperate Trails
• Desperate Trails (1939 film)