| 词条 | Azim Surani |
| 释义 |
| name = Azim Surani | birth_name = | honorific_suffix = {{post-nominals|country=GBR|CBE|FRS|FMedSci}} | birth_date = {{birth year and age |1945}} | birth_place = Kisumu, Kenya | workplaces = University of Cambridge | alma_mater = Plymouth University (BSc) University of Strathclyde (MSc) University of Cambridge (PhD) | thesis_title = Modulation of Implanting Rat Blastocysts to Macromolecular Secretions of the Uterus | thesis_url = http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.474243 | thesis_year = 1975 | doctoral_advisor = Robert Edwards | doctoral_students = Kat Arney[1] | notable_students = Anne Ferguson-Smith (postdoc)[2] | awards = Gabor Medal {{small|(2001)}} Royal Medal {{small|(2010)}} Mendel Lectures {{small|(2010)}} Gairdner Foundation International Award {{small|(2018)}}[3] | website = {{URL|https://www.gurdon.cam.ac.uk/research/surani}} }}Azim Surani {{post-nominals|country=GBR|CBE|FRS|FMedSci}}[3] (born 1945 in Kisumu, Kenya) is a developmental biologist who has been Marshall–Walton Professor at the Wellcome Trust/Cancer Research UK Gurdon Institute at the University of Cambridge since 1992, and Director of Germline and Epigenomics Research since 2013.[3][4] EducationSurani was educated at Plymouth University (BSc),{{when|date=August 2017}} the University of Strathclyde (MSc)[5] and the University of Cambridge (PhD) where his research was supervised by Robert Edwards, who later won the Nobel Prize in Physiology or Medicine.[6][5][7] Career and researchSurani co-discovered mammalian genomic imprinting with Davor Solter[8] in 1984, and subsequently examined its mechanism and the functions of imprinted genes.[6] He later established the genetic basis for germ cell specification, using a single-cell analysis in mice.[6] This genetic network also initiates the unique resetting of the germline epigenome, including comprehensive erasure of DNA methylation towards re-establishing full genomic potency.[6] Epigenetic modifications and re-establishments of imprints then generate functional differences between parental genomes whilst aberrant imprints contribute to human disease.[6] Surani's research is identifying key regulators of human germ line development and epigenome reprogramming, revealing differences between humans and mice attributable to their divergent pluripotent states and early postimplantation development.[6] He is also investigating transposable elements, host defence mechanisms, noncoding RNAs, and the potential for transgenerational epigenetic inheritance in mammals.[6] Awards and honoursSurani has received several awards for his work including the Royal Medal (2010), the Gabor Medal (2001) and the Mendel Lectures (2010).{{cn|date=March 2019}} He received the Canada Gairdner International Award, with Davor Solter, "For the discovery of mammalian genomic imprinting that causes parent-of-origin specific gene expression and its consequences for development and disease."[9] He won the Rosenstiel Award in 2006, with Solter and Mary Lyon, for "pioneering work on epigenetic gene regulation in mammalian embryos".[10] References1. ^{{cite thesis|degree=PhD|publisher=University of Cambridge|title=Epigenetic modification in the mouse zygote and regulation of imprinted genes|first= Katharine Luisa|last=Arney|date=2002|url=http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.620401|oclc=894595629}} {{FRS 1990}}{{Authority control}}{{DEFAULTSORT:Surani, Azim}}2. ^{{Cite journal|last=Ferguson-Smith|first=A. C.|last2=Cattanach|first2=B. M.|last3=Barton|first3=S. C.|last4=Beechey|first4=C. V.|last5=Surani|first5=M. A.|year=1991|title=Embryological and molecular investigations of parental imprinting on mouse chromosome 7|journal=Nature|volume=351|issue=6328|pages=667–670|doi=10.1038/351667a0|issn=0028-0836|pmid=2052093}} {{closed access}} 3. ^{{Scopus id}} 4. ^{{cite web|url=https://www.gurdon.cam.ac.uk/research/surani|title=Azim Surani — The Gurdon Institute|website=Gurdon.cam.ac.uk|accessdate=29 August 2017}} 5. ^1 {{cite web|first=Alan|last=McFarlane|year=2009|archiveurl=https://web.archive.org/web/20160306030252/http://www.alanmacfarlane.com/DO/filmshow/suranitx1.htm|archivedate=2016-03-06|url=http://www.alanmacfarlane.com/DO/filmshow/suranitx1.htm|website=alanmacfarlane.com|title=Azim Surani interviewed by Alan Macfarlane}} 6. ^1 2 3 4 5 6 7 8 {{cite web|archiveurl=https://web.archive.org/web/20151117013606/https://royalsociety.org/people/azim-surani-12370/|archivedate=2015-11-17|url=https://royalsociety.org/people/azim-surani-12370/|website=royalsociety.org|title=Professor Azim Surani|publisher=Royal Society|location=London|author=Anon|year=1990}} One or more of the preceding sentences incorporates text from the royalsociety.org website where: {{quote|“All text published under the heading 'Biography' on Fellow profile pages is available under Creative Commons Attribution 4.0 International License.” --{{Cite web |url=https://royalsociety.org/about-us/terms-conditions-policies/ |title=Archived copy |access-date=2017-08-30 |archive-url=https://web.archive.org/web/20161111170346/https://royalsociety.org/about-us/terms-conditions-policies/ |archive-date=2016-11-11 |dead-url=bot: unknown |df= }}}} 7. ^{{cite thesis|degree=PhD|publisher=University of Cambridge|title=Modulation of Implanting Rat Blastocysts to Macromolecular Secretions of the Uterus|first= M. A. H.|last=Surani|date=1975|url=http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.474243|website=ethos.bl.uk|oclc=500574338}} 8. ^{{cite journal|authors=Anne C. Ferguson-Smith, Deborah Bourc'his |year=2018 |title=The discovery and importance of genomic imprinting |journal=eLife |volume=7 |page=e42368 |doi=10.7554/eLife.42368 |pmc=6197852}} 9. ^{{Cite news|url=http://gairdner.org/winners/current-winners/#Davor_Solter|title=Gairdner Awards 2018 Laureates {{!}} Gairdner Foundation|work=Gairdner Foundation|access-date=2018-09-21|language=en-US}} 10. ^{{cite web |url=http://www.brandeis.edu/rosenstiel/rosenstielaward/past.html |title=Past Winners |publisher=Brandeis University |accessdate=25 March 2019 }} 6 : Living people|Fellows of the Royal Society|Fellows of the Academy of Medical Sciences|British Ismailis|1945 births|Fellows of King's College, Cambridge |
| 随便看 |
|
开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。