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词条 Benita Katzenellenbogen
释义

  1. Early life

  2. Career

  3. Research

  4. References

  5. External links

{{COI|date=December 2017}}Benita S. Katzenellenbogen née Schulman (born 1945) is an American Professor of Physiology and Cell Biology at the University of Illinois at Urbana-Champaign. She has made major contributions in understanding cancer, endocrinology, and women's health, focusing on nuclear receptors and on improving the effectiveness of endocrine therapies in breast cancer. Her work has delineated structure-function relationships and mechanisms of action of estrogen receptors alpha and beta. She has elucidated the molecular basis of action of SERMs such as tamoxifen and raloxifene in treatment and prevention of breast cancer, and she has identified critical aggressiveness factors in breast tumors that promote metastasis and resistance to cancer therapies, and she has studied approaches to inhibit them.[1][2]

Early life

Benita Katzenellenbogen was born April 11, 1945, in New York City. Her father was a patent attorney with Western Electric, part of AT&T, and her mother was a school teacher in New York. Katzenellenbogen attended public schools and did her undergraduate training in Biology at the City University of New York (Brooklyn College), receiving her BA summa cum laude in Biology in 1965. She obtained her Ph.D. in Biology at Harvard University in 1970, doing research in Developmental Biology with Professor Fotis Kafatos.[3][4] She completed postdoctoral work in endocrinology and cancer biology at the University of Illinois at Urbana-Champaign from 1970 to 1971 with Professor Jack Gorski.[5][6]

Career

Benita Katzenellenbogen began her academic career as an Assistant Professor of Physiology at the University of Illinois and College of Medicine at Urbana-Champaign in 1971. She was promoted to Associate Professor in 1976 and to Full Professor in 1982. She is currently the Swanlund Professor of Molecular and Integrative Physiology, Cell and Developmental Biology at the University of Illinois. She also holds affiliate appointments in the Institute for Genomic Biology[7] and the Beckman Institute for Advanced Science and Technology at Illinois.[8] Additionally, from September 1977 to June 1978, Katzenellenbogen did sabbatical research at the University of California at San Francisco, and in 2005 she conducted collaborative sabbatical research at the Genome Institute of Singapore.[9] Her professional career has been directed at elucidating cellular and molecular mechanisms of steroid hormone-mediated regulation of reproductive target tissues and of tumors that develop in these tissues, especially breast cancer.[2][10]

Katzenellenbogen has published over 330 research articles, contributed 30 book chapters, and co-edited a book on hormone-dependent cancers.[11] She has trained more than 90 graduate students and postdoctoral scientists and has overseen numerous undergraduates in their biomedical research. For her activities in mentoring, she was recognized with the Mentor Award from Women in Endocrinology in 2011.[12] She is also the recipient of numerous other awards, honors, and special fellowships from governmental, private, and academic institutions. These include the MERIT Award from the National Cancer Institute of the NIH (1991-1999), the Brinker Award for Scientific Distinction from the Susan G. Komen for the Cure Breast Cancer Foundation (2009),[2] the Jill Rose Award from The Breast Cancer Research Foundation (1998),[13] the Ernst Oppenheimer Award (1984),[14] and the Roy O. Greep Lecture Award from The Endocrine Society (2006).[15] In 2016, she shared the Fred Conrad Koch Lifetime Achievement Award from The Endocrine Society with Dr. John Katzenellenbogen.[16] She was elected a Fellow of the American Academy of Arts and Sciences (1993),[17] and she received a Distinguished Alumni Award from The City University of New York in 2002[18] and an Honorary Degree from the University of Milan, Italy (2007).

She has been a leader in her profession, having served on many important committees and review panels, journal editorial boards, and as President of The Endocrine Society (2000–2001).[19] She served full terms on the NIH Endocrinology (1979-1983) and Biochemical Endocrinology Study Sections (1995-1999), was Vice Chair of the American Cancer Society Review Panel on Biochemistry and Endocrinology (1992-1993), and was Chair of the NIH, NIDDK Board of Scientific Counselors (1988-1989). She served as a member of the External Advisory Committee for the NIH Nuclear Receptor Signaling Atlas (2002-2012) and on Review Panels for Komen for the Cure, the DOD Breast Cancer Program, and on NIH graduate and postdoctoral fellowship review committees. She co-chaired the Hormone Action Gordon Research Conference in 1988[20] and the Keystone Symposium on The Nuclear Receptor Superfamily in 2002.[21]

Research

Katzenellenbogen has elucidated structure-function relationships and actions of estrogen receptors alpha and beta,[22][23][24][25][26] and demonstrated that estrogens have a broad spectrum of effects on gene networks and pathways in breast cancer and other cells.[27][28] This research has contributed to understanding of the molecular basis for the action of selective estrogen receptor modulators (SERMs) such as tamoxifen in target cells,[29][30][31][32] and for the development of anti-hormonal treatments used in breast cancer treatment and prevention.[33][34] Her laboratory demonstrated that estrogen receptors regulate and function along with multiple cell signaling pathways involving kinase cascades and growth factors,[35][36][37] and that these inputs converge at the level of chromatin to regulate gene expression and cell signaling.[26] This work presaged the current active interest in both the non-genomic actions of estrogens[36][38][39] and the cross-talk between nuclear receptors and other cell signaling pathways and their roles in endocrine resistance. Her laboratory has also identified factors associated with aggressiveness and early time to cancer recurrence[40][41][42][43][44][45][46] and their regulation in different subtypes of breast cancer.[47] She has also characterized the activities of estrogens in menopausal hormone replacement therapies and diverse ligands for estrogen receptors,[36][48] including environmental estrogens,[49] phytoestrogens such as genistein,[23][50][51] and estrogen receptor subtype-selective ligands in various estrogen target tissues.[52][53][54][55]

References

1. ^{{Cite web|url=https://www.endocrine.org/news-room/press-release-archives/2015/endocrine-society-announces-2016-laureate-award-winners|title=Endocrine Society Announces 2016 Laureate Award Winners {{!}} Endocrine Society|website=www.endocrine.org|language=en|access-date=2017-12-23}}
2. ^1 2 {{Cite web|url=https://ww5.komen.org/WhatWeDo/AwardsandRecognition/AwardsRecognition.html|title=Breast Cancer Awards & Recognition {{!}} Susan G. Komen®|website=ww5.komen.org|access-date=2017-12-23}}
3. ^{{cite journal |doi=10.1016/0022-1910(71)90016-3 |title=General esterases of silkmoth moulting fluid: Preliminary characterization |journal=Journal of Insect Physiology |volume=17 |issue=6 |pages=1139–43 |year=1971 |last1=Katzenellenbogen |first1=Benita S |last2=Kafatos |first2=Fotis C }}
4. ^{{cite journal |doi=10.1016/0022-1910(71)90123-5 |title=Proteinases of silkmoth moulting fluid: Physical and catalytic properties |journal=Journal of Insect Physiology |volume=17 |issue=4 |pages=775–800 |year=1971 |last1=Katzenellenbogen |first1=Benita S |last2=Kafatos |first2=Fotis C }}
5. ^{{cite journal |pmid=4335193 |year=1972 |author1=Katzenellenbogen |first1=B. S |title=Estrogen action in vitro. Induction of the synthesis of a specific uterine protein |journal=The Journal of Biological Chemistry |volume=247 |issue=4 |pages=1299–305 |last2=Gorski |first2=J }}
6. ^{{cite journal |doi=10.1210/endo-92-1-125 |pmid=4681918 |title=Estrone Interaction with the Rat Uterus: In Vitro Response and Nuclear Uptake1 |journal=Endocrinology |volume=92 |issue=1 |pages=125–34 |year=1973 |last1=Ruh |first1=Thomas S |last2=Katzenellenbogen |first2=Benita S |last3=Katzenellenbogen |first3=John A |last4=Gorski |first4=JAC }}
7. ^{{Cite web|url=https://www.igb.illinois.edu/people/k|title=People {{!}} Carl R. Woese Institute for Genomic Biology|website=www.igb.illinois.edu|language=en|access-date=2017-12-22}}
8. ^{{Cite web|url=https://beckman.illinois.edu/news/2014/02/understanding-the-nature-of-cancer-one-cell-at-a-time|title=Understanding the Nature of Cancer, One Cell at a Time, News, Beckman Institute, University of Illinois|last=Technology|first=Beckman Institute for Advanced Science and|website=beckman.illinois.edu|language=en|access-date=2017-12-22}}
9. ^{{cite journal |doi=10.1371/journal.pgen.0030087 |pmid=17542648 |pmc=1885282 |title=Whole-Genome Cartography of Estrogen Receptor α Binding Sites |journal=PLoS Genetics |volume=3 |issue=6 |pages=e87 |year=2007 |last1=Lin |first1=Chin-Yo |last2=Vega |first2=Vinsensius B |last3=Thomsen |first3=Jane S |last4=Zhang |first4=Tao |last5=Kong |first5=Say Li |last6=Xie |first6=Min |last7=Chiu |first7=Kuo Ping |last8=Lipovich |first8=Leonard |last9=Barnett |first9=Daniel H |last10=Stossi |first10=Fabio |last11=Yeo |first11=Ailing |last12=George |first12=Joshy |last13=Kuznetsov |first13=Vladimir A |last14=Lee |first14=Yew Kok |last15=Charn |first15=Tze Howe |last16=Palanisamy |first16=Nallasivam |last17=Miller |first17=Lance D |last18=Cheung |first18=Edwin |last19=Katzenellenbogen |first19=Benita S |last20=Ruan |first20=Yijun |last21=Bourque |first21=Guillaume |last22=Wei |first22=Chia-Lin |last23=Liu |first23=Edison T }}
10. ^{{Cite news|url=https://endocrinenews.endocrine.org/meet-the-2016-laureate-award-winners-benita-katzenellenbogen-phd-and-john-katzenellenbogen-phd/|title=Meet the 2016 Laureate Award Winners: Benita Katzenellenbogen, PhD, and John Katzenellenbogen, PhD - Endocrine News|date=2016-01-25|work=Endocrine News|access-date=2017-12-23|language=en-US}}
11. ^{{Cite book|title=Hormone-Dependent Cancer|last=Pasqualini|first=Jorge|last2=Katzenellenbogen|first2=Benita|publisher=Taylor & Francis|year=1996|isbn=9780824796976|location=|pages=}}
12. ^{{Cite web|url=https://www.women-in-endo.org/awards/types-of-awards/mentor-awards-2/mentor-awards/|title=Past Mentor Award Recipients {{!}} Women in Endocrinology|website=www.women-in-endo.org|language=en-US|access-date=2017-12-22}}
13. ^{{Cite web|url=http://legacy.bcrfcure.org/action_jillrose.html|title=BCRF :: Jill Rose Award|last=rayogram|website=legacy.bcrfcure.org|language=en|access-date=2017-12-22}}
14. ^{{Cite web|url=https://www.endocrine.org/awards/laureate-awards/ernst-oppenheimer-award#!?year=1984|title=Ernst Oppenheimer Award {{!}} Endocrine Society|website=www.endocrine.org|language=en|access-date=2017-12-22}}
15. ^{{Cite web|url=https://www.endocrine.org/awards/laureate-awards/roy-o-greep-award-for-outstanding-research|title=Roy O. Greep Award for Outstanding Research {{!}} Endocrine Society|website=www.endocrine.org|language=en|access-date=2017-12-23}}
16. ^{{Cite web|url=https://www.amacad.org/content/publications/pubContent.aspx?d=22294|title=Noteworthy - American Academy of Arts & Sciences|access-date=2017-12-22}}
17. ^{{Cite web|url=https://www.amacad.org/multimedia/pdfs/publications/bookofmembers/ChapterK.pdf|title=American Academy of Arts and Sciences Fellows Listing|last=|first=|date=January 1, 2017|website=amacad.org|page=316|archive-url=https://www.amacad.org/multimedia/pdfs/publications/bookofmembers/ChapterK.pdf|archive-date=January 1, 2017|dead-url=no|access-date=December 22, 2017}}
18. ^{{Cite web|url=https://news.illinois.edu/view/6367/212253|title=News Bureau {{!}} ILLINOIS|last=Illinois|first=Inside|website=news.illinois.edu|language=en-US|access-date=2017-12-22}}
19. ^{{Cite web|url=https://www.endocrine.org/about-us/history/hall-of-presidents|title=Hall of Presidents {{!}} Endocrine Society|website=www.endocrine.org|language=en|access-date=2017-12-22}}
20. ^{{Cite web|url=https://www.grc.org/mechanisms-of-hormone-action-conference/|title=Mechanisms of Hormone Action - Gordon Research Conferences|website=www.grc.org|language=en|access-date=2017-12-22}}
21. ^{{Cite web|url=https://www.keystonesymposia.org/index.cfm?e=web.Meeting.Program&meetingid=597|title=Keystone Symposia {{!}} Scientific Conferences on Biomedical and Life Science Topics|website=www.keystonesymposia.org|language=en|access-date=2017-12-22}}
22. ^{{cite journal |doi=10.1210/en.2003-1682 |pmid=15033914 |title=Transcriptional Profiling of Estrogen-Regulated Gene Expression via Estrogen Receptor (ER) α or ERβ in Human Osteosarcoma Cells: Distinct and Common Target Genes for These Receptors |journal=Endocrinology |volume=145 |issue=7 |pages=3473–86 |year=2004 |last1=Stossi |first1=Fabio |last2=Barnett |first2=Daniel H |last3=Frasor |first3=Jonna |last4=Komm |first4=Barry |last5=Lyttle |first5=C. Richard |last6=Katzenellenbogen |first6=Benita S }}
23. ^1 {{cite journal |doi=10.1210/me.2007-0356 |pmid=18258689 |pmc=2366177 |title=Estrogen Receptors α and β as Determinants of Gene Expression: Influence of Ligand, Dose, and Chromatin Binding |journal=Molecular Endocrinology |volume=22 |issue=5 |pages=1032–43 |year=2008 |last1=Chang |first1=Edmund C |last2=Charn |first2=Tze Howe |last3=Park |first3=Sung-Hee |last4=Helferich |first4=William G |last5=Komm |first5=Barry |last6=Katzenellenbogen |first6=John A |last7=Katzenellenbogen |first7=Benita S }}
24. ^{{cite journal |doi=10.1128/MCB.01476-08 |pmid=19188451 |pmc=2655624 |title=Estrogen Receptor Alpha Represses Transcription of Early Target Genes via p300 and CtBP1 |journal=Molecular and Cellular Biology |volume=29 |issue=7 |pages=1749–59 |year=2009 |last1=Stossi |first1=F |last2=Madak-Erdogan |first2=Z |last3=Katzenellenbogen |first3=B. S }}
25. ^{{cite journal |pmid=8226955 |url=http://www.jbc.org/cgi/pmidlookup?view=long&pmid=8226955 |year=1993 |author1=Wrenn |first1=C. K |title=Structure-function analysis of the hormone binding domain of the human estrogen receptor by region-specific mutagenesis and phenotypic screening in yeast |journal=The Journal of Biological Chemistry |volume=268 |issue=32 |pages=24089–98 |last2=Katzenellenbogen |first2=B. S }}
26. ^1 {{cite journal|last1=Madak-Erdogan|first1=Z|last2=Charn|first2=T.-H|last3=Jiang|first3=Y|last4=Liu|first4=E. T|last5=Katzenellenbogen|first5=J. A|last6=Katzenellenbogen|first6=B. S|year=2014|title=Integrative genomics of gene and metabolic regulation by estrogen receptors alpha and beta, and their coregulators|url=|journal=Molecular Systems Biology|volume=9|pages=676|doi=10.1038/msb.2013.28|pmc=3964312|pmid=23774759|via=}}
27. ^{{cite journal |doi=10.1210/en.2003-0567 |pmid=12959972 |title=Profiling of Estrogen Up- and Down-Regulated Gene Expression in Human Breast Cancer Cells: Insights into Gene Networks and Pathways Underlying Estrogenic Control of Proliferation and Cell Phenotype |journal=Endocrinology |volume=144 |issue=10 |pages=4562–74 |year=2003 |last1=Frasor |first1=Jonna |last2=Danes |first2=Jeanne M |last3=Komm |first3=Barry |last4=Chang |first4=Ken C. N |last5=Lyttle |first5=C. Richard |last6=Katzenellenbogen |first6=Benita S }}
28. ^{{cite journal |doi=10.1210/en.2006-0563 |pmid=16809442 |title=Impact of Estrogen Receptor β on Gene Networks Regulated by Estrogen Receptor α in Breast Cancer Cells |journal=Endocrinology |volume=147 |issue=10 |pages=4831–42 |year=2006 |last1=Chang |first1=Edmund C |last2=Frasor |first2=Jonna |last3=Komm |first3=Barry |last4=Katzenellenbogen |first4=Benita S }}
29. ^{{cite journal |pmid=9122238 |pmc=20131 |year=1997 |author1=Montano |first1=M. M |title=The quinone reductase gene: A unique estrogen receptor-regulated gene that is activated by antiestrogens |journal=Proceedings of the National Academy of Sciences of the United States of America |volume=94 |issue=6 |pages=2581–6 |last2=Katzenellenbogen |first2=B. S |bibcode=1997PNAS...94.2581M |doi=10.1073/pnas.94.6.2581 }}
30. ^{{cite journal |pmid=10359819 |pmc=22022 |year=1999 |author1=Montano |first1=M. M |title=An estrogen receptor-selective coregulator that potentiates the effectiveness of antiestrogens and represses the activity of estrogens |journal=Proceedings of the National Academy of Sciences of the United States of America |volume=96 |issue=12 |pages=6947–52 |last2=Ekena |first2=K |last3=Delage-Mourroux |first3=R |last4=Chang |first4=W |last5=Martini |first5=P |last6=Katzenellenbogen |first6=B. S |bibcode=1999PNAS...96.6947M |doi=10.1073/pnas.96.12.6947 }}
31. ^{{cite journal |pmid=14973112 |url=http://cancerres.aacrjournals.org/cgi/pmidlookup?view=long&pmid=14973112 |year=2004 |author1=Frasor |first1=J |title=Selective estrogen receptor modulators: Discrimination of agonistic versus antagonistic activities by gene expression profiling in breast cancer cells |journal=Cancer Research |volume=64 |issue=4 |pages=1522–33 |last2=Stossi |first2=F |last3=Danes |first3=J. M |last4=Komm |first4=B |last5=Lyttle |first5=C. R |last6=Katzenellenbogen |first6=B. S |doi=10.1158/0008-5472.CAN-03-3326 }}
32. ^{{cite journal |doi=10.1210/en.2011-1100 |pmid=21862609 |pmc=3199013 |title=Repressor of Estrogen Receptor Activity (REA) is Essential for Mammary Gland Morphogenesis and Functional Activities: Studies in Conditional Knockout Mice |journal=Endocrinology |volume=152 |issue=11 |pages=4336–49 |year=2011 |last1=Park |first1=Sunghee |last2=Zhao |first2=Yuechao |last3=Yoon |first3=Sangyeon |last4=Xu |first4=Jianming |last5=Liao |first5=Lan |last6=Lydon |first6=John |last7=Demayo |first7=Franco |last8=O'Malley |first8=Bert W |last9=Katzenellenbogen |first9=Benita S }}
33. ^{{cite journal |doi=10.1053/j.seminoncol.2004.01.004 |pmid=15052541 |title=Therapeutic targeting in the estrogen receptor hormonal pathway |journal=Seminars in Oncology |volume=31 |issue=1 Suppl 3 |pages=28–38 |year=2004 |last1=Katzenellenbogen |first1=Benita S |last2=Frasor |first2=Jonna }}
34. ^{{cite journal |doi=10.1016/j.ctrv.2016.08.008 |pmid=27643748 |title=Endocrine treatment in breast cancer: Cure, resistance and beyond |journal=Cancer Treatment Reviews |volume=50 |pages=68–81 |year=2016 |last1=Tryfonidis |first1=Konstantinos |last2=Zardavas |first2=Dimitrios |last3=Katzenellenbogen |first3=Benita S |last4=Piccart |first4=Martine }}
35. ^{{cite journal |doi=10.1210/endo-126-2-891 |pmid=2404751 |title=Multihormonal Regulation of the Progesterone Receptor in MCF-7 Human Breast Cancer Cells: Interrelationships among Insulin/Insulin-Like Growth Factor-I, Serum, and Estrogen |journal=Endocrinology |volume=126 |issue=2 |pages=891–8 |year=1990 |last1=Katzenellenbogen |first1=Benita S |last2=Jane Norman |first2=Mary }}
36. ^1 2 {{cite journal |doi=10.1126/scisignal.aad8170 |pmid=27221711 |pmc=4896643 |title=Design of pathway preferential estrogens that provide beneficial metabolic and vascular effects without stimulating reproductive tissues |journal=Science Signaling |volume=9 |issue=429 |pages=ra53 |year=2016 |last1=Madak-Erdogan |first1=Z |last2=Kim |first2=S. H |last3=Gong |first3=P |last4=Zhao |first4=Y. C |last5=Zhang |first5=H |last6=Chambliss |first6=K. L |last7=Carlson |first7=K. E |last8=Mayne |first8=C. G |last9=Shaul |first9=P. W |last10=Korach |first10=K. S |last11=Katzenellenbogen |first11=J. A |last12=Katzenellenbogen |first12=B. S }}
37. ^{{cite journal |doi=10.1128/MCB.00821-10 |pmid=20956553 |pmc=3019850 |title=Genomic Collaboration of Estrogen Receptor   and Extracellular Signal-Regulated Kinase 2 in Regulating Gene and Proliferation Programs |journal=Molecular and Cellular Biology |volume=31 |issue=1 |pages=226–36 |year=2010 |last1=Madak-Erdogan |first1=Z |last2=Lupien |first2=M |last3=Stossi |first3=F |last4=Brown |first4=M |last5=Katzenellenbogen |first5=B. S }}
38. ^{{cite journal |doi=10.1210/me.2005-0186 |pmid=16306086 |title=Estrogen Dendrimer Conjugates that Preferentially Activate Extranuclear, Nongenomic Versus Genomic Pathways of Estrogen Action |journal=Molecular Endocrinology |volume=20 |issue=3 |pages=491–502 |year=2006 |last1=Harrington |first1=William R |last2=Kim |first2=Sung Hoon |last3=Funk |first3=Cory C |last4=Madak-Erdogan |first4=Zeynep |last5=Schiff |first5=Rachel |last6=Katzenellenbogen |first6=John A |last7=Katzenellenbogen |first7=Benita S }}
39. ^{{cite journal |doi=10.1210/me.2008-0059 |pmid=18617595 |pmc=2631368 |title=Nuclear and Extranuclear Pathway Inputs in the Regulation of Global Gene Expression by Estrogen Receptors |journal=Molecular Endocrinology |volume=22 |issue=9 |pages=2116–27 |year=2008 |last1=Madak-Erdogan |first1=Zeynep |last2=Kieser |first2=Karen J |last3=Kim |first3=Sung Hoon |last4=Komm |first4=Barry |last5=Katzenellenbogen |first5=John A |last6=Katzenellenbogen |first6=Benita S }}
40. ^{{cite journal |doi=10.1186/bcr2913 |pmid=21707964 |pmc=3218959 |title=Reversal of endocrine resistance in breast cancer: Interrelationships among 14-3-3ζ, FOXM1, and a gene signature associated with mitosis |journal=Breast Cancer Research |volume=13 |issue=3 |pages=R70 |year=2011 |last1=Bergamaschi |first1=Anna |last2=Christensen |first2=Barbara L |last3=Katzenellenbogen |first3=Benita S }}
41. ^{{cite journal |doi=10.1158/1541-7786.MCR-13-0588 |pmid=24505128 |pmc=4020978 |title=Novel Roles for ERK5 and Cofilin as Critical Mediators Linking ERα-Driven Transcription, Actin Reorganization, and Invasiveness in Breast Cancer |journal=Molecular Cancer Research |volume=12 |issue=5 |pages=714–27 |year=2014 |last1=Madak-Erdogan |first1=Zeynep |last2=Ventrella |first2=Rosa |last3=Petry |first3=Luke |last4=Katzenellenbogen |first4=Benita S }}
42. ^{{cite journal |doi=10.1186/s13058-014-0436-4 |pmid=25213081 |pmc=4303117 |title=The forkhead transcription factor FOXM1 promotes endocrine resistance and invasiveness in estrogen receptor-positive breast cancer by expansion of stem-like cancer cells |journal=Breast Cancer Research |volume=16 |issue=5 |pages=436 |year=2014 |last1=Bergamaschi |first1=Anna |last2=Madak-Erdogan |first2=Zeynep |last3=Kim |first3=Yu Jin |last4=Choi |first4=Yoon-La |last5=Lu |first5=Hailing |last6=Katzenellenbogen |first6=Benita S }}
43. ^{{cite journal |doi=10.1210/mend.10.11.8923465 |pmid=8923465 |title=Constitutively active human estrogen receptors containing amino acid substitutions for tyrosine 537 in the receptor protein |journal=Molecular Endocrinology |volume=10 |issue=11 |pages=1388–98 |year=1996 |last1=Weis |first1=K E |last2=Ekena |first2=K |last3=Thomas |first3=J A |last4=Lazennec |first4=G |last5=Katzenellenbogen |first5=B S }}
44. ^{{cite journal |doi=10.1210/mend.11.9.9983 |pmid=9259327 |title=Mechanistic Aspects of Estrogen Receptor Activation Probed with Constitutively Active Estrogen Receptors: Correlations with DNA and Coregulator Interactions and Receptor Conformational Changes |journal=Molecular Endocrinology |volume=11 |issue=9 |pages=1375–86 |year=1997 |last1=Lazennec |first1=Gwendal |last2=Ediger |first2=Tracy R |last3=Petz |first3=Larry N |last4=Nardulli |first4=Ann M |last5=Katzenellenbogen |first5=Benita S }}
45. ^{{cite journal |doi=10.7554/eLife.12792 |pmid=26836308 |pmc=4821807 |title=Estrogen receptor alpha somatic mutations Y537S and D538G confer breast cancer endocrine resistance by stabilizing the activating function-2 binding conformation |journal=eLife |volume=5 |year=2016 |last1=Fanning |first1=Sean W |last2=Mayne |first2=Christopher G |last3=Dharmarajan |first3=Venkatasubramanian |last4=Carlson |first4=Kathryn E |last5=Martin |first5=Teresa A |last6=Novick |first6=Scott J |last7=Toy |first7=Weiyi |last8=Green |first8=Bradley |last9=Panchamukhi |first9=Srinivas |last10=Katzenellenbogen |first10=Benita S |last11=Tajkhorshid |first11=Emad |last12=Griffin |first12=Patrick R |last13=Shen |first13=Yang |last14=Chandarlapaty |first14=Sarat |last15=Katzenellenbogen |first15=John A |last16=Greene |first16=Geoffrey L }}
46. ^{{cite journal |doi=10.1158/0008-5472.CAN-17-1265 |pmid=28904064 |pmc=5645250 |title=Structurally Novel Antiestrogens Elicit Differential Responses from Constitutively Active Mutant Estrogen Receptors in Breast Cancer Cells and Tumors |journal=Cancer Research |volume=77 |issue=20 |pages=5602–5613 |year=2017 |last1=Zhao |first1=Yuechao |last2=Laws |first2=Mary J |last3=Guillen |first3=Valeria Sanabria |last4=Ziegler |first4=Yvonne |last5=Min |first5=Jian |last6=Sharma |first6=Abhishek |last7=Kim |first7=Sung Hoon |last8=Chu |first8=David |last9=Park |first9=Ben Ho |last10=Oesterreich |first10=Steffi |last11=Mao |first11=Chengjian |last12=Shapiro |first12=David J |last13=Nettles |first13=Kendall W |last14=Katzenellenbogen |first14=John A |last15=Katzenellenbogen |first15=Benita S }}
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52. ^{{cite journal |doi=10.1021/jm010254a |pmid=11708925 |title=Estrogen Receptor-β Potency-Selective Ligands:  Structure−Activity Relationship Studies of Diarylpropionitriles and Their Acetylene and Polar Analogues |journal=Journal of Medicinal Chemistry |volume=44 |issue=24 |pages=4230–51 |year=2001 |last1=Meyers |first1=Marvin J |last2=Sun |first2=Jun |last3=Carlson |first3=Kathryn E |last4=Marriner |first4=Gwendolyn A |last5=Katzenellenbogen |first5=Benita S |last6=Katzenellenbogen |first6=John A }}
53. ^{{cite journal |doi=10.1210/endo.143.3.8704 |pmid=11861516 |title=Antagonists Selective for Estrogen Receptor α |journal=Endocrinology |volume=143 |issue=3 |pages=941–7 |year=2002 |last1=Sun |first1=Jun |last2=Huang |first2=Ying R |last3=Harrington |first3=William R |last4=Sheng |first4=Shubin |last5=Katzenellenbogen |first5=John A |last6=Katzenellenbogen |first6=Benita S }}
54. ^{{cite journal|last1=Harris|first1=Heather A|last2=Katzenellenbogen|first2=John A|last3=Katzenellenbogen|first3=Benita S|year=2002|title=Characterization of the Biological Roles of the Estrogen Receptors, ERα and ERβ, in Estrogen Target Tissues in Vivo through the Use of an ERα-Selective Ligand|url=|journal=Endocrinology|volume=143|issue=11|pages=4172–7|doi=10.1210/en.2002-220403|pmid=12399409|via=}}
55. ^{{cite journal |doi=10.1210/me.2002-0341 |pmid=12554752 |title=Molecular Basis for the Subtype Discrimination of the Estrogen Receptor-β-Selective Ligand, Diarylpropionitrile |journal=Molecular Endocrinology |volume=17 |issue=2 |pages=247–58 |year=2003 |last1=Sun |first1=Jun |last2=Baudry |first2=Jerome |last3=Katzenellenbogen |first3=John A |last4=Katzenellenbogen |first4=Benita S }}

External links

  • {{PubMedAuthorSearch|Katzenellenbogen|B}}
  • [https://mcb.illinois.edu/faculty/profile/katzenel University of Illinois profile page]
{{authority control}}{{DEFAULTSORT:Katzenellenbogen, Benita}}

9 : Harvard University alumni|1945 births|Living people|American women biologists|American physiologists|Scientists from New York City|Brooklyn College alumni|American endocrinologists|University of Illinois at Urbana–Champaign faculty
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