| 词条 | Beta-Ketoisocaproic acid |
| 释义 |
| Watchedfields = | verifiedrevid = | Name = β-Ketoisocaproic acid | ImageFile = Beta-Ketoisocaproic acid.svg | ImageFile_Ref = {{chemboximage|correct|??}} | ImageSize = 244 | ImageName = Skeletal formula of beta-ketoisocaproic acid | IUPACName = 4-methyl-3-oxopentanoic acid | SystematicName = 4-methyl-3-oxopentanoic acid[1] | OtherNames = 4-Methyl-2-oxovaleric acid |Section1={{Chembox Identifiers | IUPHAR_ligand = | CASNo = 5650-76-0 | CASNo_Ref = {{cascite|correct|CAS}} | PubChem = 440024 | ChemSpiderID = 389038 | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | EINECS = | UNNumber = | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank = | KEGG = C03467 | KEGG_Ref = {{keggcite|correct|kegg}} | MeSHName = Beta-ketoisocaproic+acid | ChEBI_Ref = {{ebicite|correct|EBI}} | ChEBI = 29024 | ChEMBL = | ChEMBL_Ref = | Beilstein = | 3DMet = | SMILES = CC(C)C(CC(O)=O)=O | SMILES1 = | StdInChI = | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | InChI = | StdInChIKey = ZXLSKTZECNUVIS-UHFFFAOYSA-N | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | InChIKey = }} |Section2={{Chembox Properties | C = 6 | H = 10 | O = 3 | Density = 1.1 g cm−3 (at 20 °C) | MeltingPtC = | BoilingPtC = 236 | BoilingPt_notes = ±23 at 760 mmHg | LogP = 0.36 | pKa = | pKb = }} |Section3={{Chembox Hazards | EUClass = {{Hazchem C}} | RPhrases = {{R34}} | SPhrases = {{S26}}, {{S36/37/39}}, {{S45}} }} }}β-Ketoisocaproic acid is an intermediate in the metabolism of leucine.[2][3] Its metabolic precursor and metabolic product in the leucine metabolic pathway are {{nowrap|β-leucine}} and β-ketoisocaproyl-CoA, respectively.[2] References1. ^{{PubChem|440024}} {{Amino acid metabolism intermediates|state=collapsed}}{{DEFAULTSORT:Ketoisocaproic acid, beta-}}{{Organic-compound-stub}}2. ^1 {{cite book | vauthors=Kohlmeier M | title=Nutrient Metabolism: Structures, Functions, and Genes | date=May 2015 | publisher=Academic Press | isbn=978-0-12-387784-0 | pages=385–388 | edition=2nd | section-url=https://books.google.com/books?id=aTQTAAAAQBAJ&pg=PA387&q=beta-hydroxy%20beta-methylbutyrate%20HMB#v=onepage | url=https://books.google.com/books?id=aTQTAAAAQBAJ&printsec=frontcover#v=onepage | accessdate=6 June 2016 | section=Leucine | quote= Energy fuel: Eventually, most Leu is broken down, providing about 6.0kcal/g. About 60% of ingested Leu is oxidized within a few hours ... Ketogenesis: A significant proportion (40% of an ingested dose) is converted into acetyl-CoA and thereby contributes to the synthesis of ketones, steroids, fatty acids, and other compounds ... [https://books.google.com/books?id=aTQTAAAAQBAJ&pg=PA386#v=onepage&q&f=false Figure 8.57: Metabolism of {{smallcaps all|L-leucine}}]}} 3. ^{{cite web|title=Leucine metabolism|url=http://www.brenda-enzymes.org/pathways/Maps/pathways/leucine_metabolism.svg|website=BRENDA|publisher=Technische Universität Braunschweig|accessdate=12 August 2016}} 1 : Keto acids |
| 随便看 |
|
开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。