| 词条 | Biliatresone |
| 释义 |
| Verifiedfields = changed | Watchedfields = changed | verifiedrevid = | Name = Biliatresone | ImageFile =Biliatresone-jrp.png | ImageSize = 200px | IUPACName = 1-(4,6-Dimethoxybenzo[d][1,3]dioxol-5-yl)-2-(2-hydroxyphenyl)prop-2-en-1-one | OtherNames = |Section1={{Chembox Identifiers | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = | ChEMBL_Ref = {{ebicite|correct|EBI}} | ChEMBL = | KEGG_Ref = {{keggcite|correct|kegg}} | KEGG = | InChI = | InChIKey = | StdInChI_Ref = | StdInChI = 1S/C18H16O6/c1-10(11-6-4-5-7-12(11)19)16(20)15-13(21-2)8-14-17(18(15)22-3)24-9-23-14/h4-8,19H,1,9H2,2-3H3 | StdInChIKey_Ref = | StdInChIKey = SIKIIXNKUAAGAM-UHFFFAOYSA-N | CASNo_Ref = {{cascite|correct|CAS}} | CASNo = | ChEBI_Ref = {{ebicite|correct|EBI}} | ChEBI = 131631 | SMILES = O=C(C(C1=C(O)C=CC=C1)=C)C2=C(OC)C3=C(OCO3)C=C2OC | RTECS = | PubChem = 124079379 |Section2={{Chembox Properties | C=18 | H=16 | O=6 | Appearance = | Odor = | Density = | Solubility = | SolubleOther = | MeltingPtC = | BoilingPtC = | Viscosity = | RefractIndex = | VaporPressure = |Section7={{Chembox Hazards | ExternalSDS = | EUClass = | NFPA-H = | NFPA-R = | NFPA-F = | RPhrases = | SPhrases = | FlashPtC = | AutoignitionPtC = |Section8={{Chembox Related | OtherFunction_label = | OtherFunction = }} Biliatresone is an example of a very rare type of a naturally occurring isoflavonoid-related 1,2-diaryl-2-propenone found in Dysphania glomulifera and D. littoralis.[1][2] It has been found to cause extrahepatic biliary atresia in a zebrafish model. The enone moiety of biliatresone is particularly reactive, being enhanced by the methylenedioxy, methoxy and hydroxy groups,[3] and undergoes ready Michael addition of water and methanol. References1. ^{{Cite journal | last1 = Lorent| first1 = K. |title = Identification of a plant isoflavonoid that causes biliary atresia| pmid = 25947162 |display-authors=etal | doi=10.1126/scitranslmed.aaa1652 | volume=7 | date=May 2015 | journal=Sci Transl Med | pages=286ra67 | pmc=4784984}} 2. ^{{Cite journal | last1 = Patman| first1 = G. |title = Biliary tract: Newly identified biliatresone causes biliary atresia | pmid = 26008130 | doi=10.1038/nrgastro.2015.91 | volume=12 | year=2015 | journal=Nat Rev Gastroenterol Hepatol | pages=369}} 3. ^{{Cite journal | last1 = Koo| first1 = K.A. |title = Reactivity of biliatresone, a natural biliary toxin, with glutathione, histamine, and amino acids | pmid = 26713899 |display-authors=etal | doi=10.1021/acs.chemrestox.5b00308 | volume=29 | year=2016 | journal=Chem. Res. Toxicol. | pages=142–9| pmc=4757443 }} 2 : Benzodioxoles|Phenols |
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