| 释义 |
- Function
- References
- Further reading
{{Infobox_gene}}BMP/retinoic acid inducible neural specific 3 is a protein that in humans is encoded by the BRINP3 gene. [1]FunctionThis gene is overexpressed in pituitary tumors but is underexpressed in tongue squamous cell carcinomas, ulcerative colitis, and peri-implantitis. Polymorphisms that increase expression of this gene have been shown to increase vascular inflammation, and an association of this gene with myocardial infarction has been demonstrated. Finally, hypermethylation of this gene may find usefulness as a biomarker for gastric cancer. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]. References 1. ^{{cite web| title = Entrez Gene: BMP/retinoic acid inducible neural specific 3| url = https://www.ncbi.nlm.nih.gov/gene/339479| accessdate = 2018-08-03}}
Further reading {{refbegin | 30em}}- {{cite journal |vauthors=Shorts-Cary L, Xu M, Ertel J, Kleinschmidt-Demasters BK, Lillehei K, Matsuoka I, Nielsen-Preiss S, Wierman ME |title=Bone morphogenetic protein and retinoic acid-inducible neural specific protein-3 is expressed in gonadotrope cell pituitary adenomas and induces proliferation, migration, and invasion |journal=Endocrinology |volume=148 |issue=3 |pages=967–75 |date=March 2007 |pmid=17138656 |doi=10.1210/en.2006-0905 |url=}}
- {{cite journal |vauthors=Vasan RS, Larson MG, Aragam J, Wang TJ, Mitchell GF, Kathiresan S, Newton-Cheh C, Vita JA, Keyes MJ, O'Donnell CJ, Levy D, Benjamin EJ |title=Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study |journal=BMC Med. Genet. |volume=8 Suppl 1 |issue= |pages=S2 |date=September 2007 |pmid=17903301 |pmc=1995617 |doi=10.1186/1471-2350-8-S1-S2 |url=}}
- {{cite journal |vauthors=Connelly JJ, Shah SH, Doss JF, Gadson S, Nelson S, Crosslin DR, Hale AB, Lou X, Wang T, Haynes C, Seo D, Crossman DC, Mooser V, Granger CB, Jones CJ, Kraus WE, Hauser ER, Gregory SG |title=Genetic and functional association of FAM5C with myocardial infarction |journal=BMC Med. Genet. |volume=9 |issue= |pages=33 |date=April 2008 |pmid=18430236 |pmc=2383879 |doi=10.1186/1471-2350-9-33 |url=}}
- {{cite journal |vauthors=Connelly JJ, Shah SH, Doss JF, Gadson S, Nelson S, Crosslin DR, Hale AB, Lou X, Wang T, Haynes C, Seo D, Crossman DC, Mooser V, Granger CB, Jones CJ, Kraus WE, Hauser ER, Gregory SG |title=Genetic and functional association of FAM5C with myocardial infarction |journal=BMC Med. Genet. |volume=9 |issue= |pages=33 |date=April 2008 |pmid=18430236 |pmc=2383879 |doi=10.1186/1471-2350-9-33 |url=}}
- {{cite journal |vauthors=Kuroiwa T, Yamamoto N, Onda T, Shibahara T |title=Expression of the FAM5C in tongue squamous cell carcinoma |journal=Oncol. Rep. |volume=22 |issue=5 |pages=1005–11 |date=November 2009 |pmid=19787213 |doi= |url=}}
- {{cite journal |vauthors=Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR |title=Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score |journal=Mol. Med. |volume=16 |issue=7-8 |pages=247–53 |date=2010 |pmid=20379614 |pmc=2896464 |doi=10.2119/molmed.2009.00159 |url=}}
- {{cite journal |vauthors=Carvalho FM, Tinoco EM, Deeley K, Duarte PM, Faveri M, Marques MR, Mendonça AC, Wang X, Cuenco K, Menezes R, Garlet GP, Vieira AR |title=FAM5C contributes to aggressive periodontitis |journal=PLoS ONE |volume=5 |issue=4 |pages=e10053 |date=April 2010 |pmid=20383335 |pmc=2850931 |doi=10.1371/journal.pone.0010053 |url=}}
- {{cite journal |vauthors=Carvalho FM, Tinoco EM, Deeley K, Duarte PM, Faveri M, Marques MR, Mendonça AC, Wang X, Cuenco K, Menezes R, Garlet GP, Vieira AR |title=FAM5C contributes to aggressive periodontitis |journal=PLoS ONE |volume=5 |issue=4 |pages=e10053 |date=April 2010 |pmid=20383335 |pmc=2850931 |doi=10.1371/journal.pone.0010053 |url=}}
- {{cite journal |vauthors=Cline JL, Beckie TM |title=The relationships between FAM5C SNP (rs10920501) variability and metabolic syndrome and inflammation in women with coronary heart disease |journal=Biol Res Nurs |volume=15 |issue=2 |pages=160–6 |date=April 2013 |pmid=22013132 |pmc=4108984 |doi=10.1177/1099800411424487 |url=}}
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