词条 | Bromo adjacent homology domain containing 1 |
释义 |
Bromo adjacent homology domain containing 1 (BAHD1) is a protein that in humans is encoded by the BAHD1 gene. BAHD1 is involved in heterochromatin formation and transcriptional repression. [1]DiscoveryBAHD1 was first cloned from a human brain cDNA library and the coding sequence was named KIAA0945.[2] Bierne and colleagues further discovered the function of BAHD1 in the regulation of chromatin structure and gene expression.[3]FunctionBAHD1 acts as a co-repressor by interacting with a set of proteins that promote chromatin compaction and regulate transcription.[3][4] Tandem-affinity purification of the BAHD1-associated protein complex in human HEK293 cells identified MIER proteins (MIER1, MIER2, MIER3), histone deacetylase HDAC1 and HDAC2, histone H3K9 methyltransferase EHMT2, heterochromatin protein 1 (HP1 alpha, HP1 beta, HP1 gamma), MBD1, TRIM28 and CDYL as partners of BAHD1.[4] Overexpression of BAHD1 in HEK293 cells induces large-scale chromatin condensation [3] and DNA methylation on autosomes.[5] The C-terminal BAH domain of BAHD1 acts as a reader for the epigenetic mark H3K27me3.[6] Ectopically expressed BAHD1 colocalizes with the heterochromatic inactive X chromosome (Xi).[3][5] Animal studiesAblation of the Bahd1 gene in the mouse alters placental development and results in hypocholesterolemia, hypoglycemia and decreased body fat.[4] Bahd1-haplodeficiency in mice decreases the efficiency of infection with the bacterial pathogen Listeria monocytogenes.[7] Clinical significanceDuring infection of human epithelial cells with the pathogen Listeria monocytogenes, BAHD1 represses interferon-stimulated genes.[7] At specific stages of infection, a Listeria nucleomodulin, LntA, acts as an inhibitor of BAHD1 and activates interferon-stimulated genes.[7][8] The BAHD1 gene is downregulated in the colon tissue in a mouse model of ulcerative colitis.[9] References1. ^{{cite web| title = Entrez Gene: BAHD1| url = https://www.ncbi.nlm.nih.gov/gene/22893| accessdate = 2016-10-22}} 2. ^{{cite journal | vauthors=Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro | journal = DNA Res| volume = 26 |issue = 6 |pages = 63–70 |date =1999 |pmid = 10231032 |pmc = |doi = 10.1038/ng0797-256 }} 3. ^1 2 3 {{cite journal |vauthors=Bierne H, Tham TN, Batsche E, Dumay A, Leguillou M, Kernéis-Golsteyn S, Regnault B, Seeler JS, Muchardt C, Feunteun J, Cossart P |title=Human BAHD1 promotes heterochromatic gene silencing |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=106 |issue=33 |pages=13826–31 |year=2009 |pmid=19666599 |pmc=2728979 |doi=10.1073/pnas.0901259106 }} 4. ^1 2 {{cite journal |vauthors=Lakisic G, Lebreton A, Pourpre R, Wendling O, Libertini E, Radford EJ, Le Guillou M, Champy MF, Wattenhofer-Donzé M, Soubigou G, Ait-Si-Ali S, Feunteun J, Sorg T, Coppée JY, Ferguson-Smith AC, Cossart P, Bierne H |title=Role of the BAHD1 Chromatin-Repressive Complex in Placental Development and Regulation of Steroid Metabolism |journal=PLoS Genet |volume=12 |issue=3 |pages=:e1005898 |year=2016 |pmid=26938916 |pmc= |doi=10.1371/journal.pgen.1005898 }} 5. ^1 {{cite journal |vauthors=Libertini E, Lebreton A, Lakisic G, Dillies MA, Beck S, Coppée JY, Cossart P, Bierne H |title= Overexpression of the Heterochromatinization Factor BAHD1 in HEK293 Cells Differentially Reshapes the DNA Methylome on Autosomes and X Chromosome |journal=Front Genet |volume= Dec 1;6:339 |issue=eCollection 2015. |pages=:e1005898 |year=2015 |pmid=26938916 |pmc= |doi=10.3389/fgene.2015.00339|url=}} 6. ^{{cite journal |vauthors=Zhao D, Zhang X, Guan H, Xiong X, Shi X, Deng H, Li H |title=The BAH domain of BAHD1 is a histone H3K27me3 reader |journal=Protein Cell |volume=7 |issue=3 |pages=222–6 |year=2016 |pmid=26850261 |pmc= |doi=10.1007/s13238-016-0243-z |url=}} 7. ^1 2 {{cite journal |vauthors=Lebreton A, Lakisic G, Job V, Fritsch L, Tham TN, Camejo A, Matteï PJ, Regnault B, Nahori MA, Cabanes D, Gautreau A, Ait-Si-Ali S, Dessen A, Cossart P, Bierne H |title=A bacterial protein targets the BAHD1 chromatin complex to stimulate type III interferon response |journal=Science |volume=331 |issue=6022 |pages=1319–21 |year=2011 |pmid=21252314 |doi=10.1126/science.1200120 |url=}} 8. ^{{cite journal |vauthors= Lebreton A, Job V, Ragon M, Le Monnier A, Dessen A, Cossart P, Bierne H |title=Structural basis for the inhibition of the chromatin repressor BAHD1 by the bacterial nucleomodulin LntA |journal=MBio |volume=21 |issue=5(1):e00775-13 |pages= |year=2014 |pmid=24449750 |doi=10.1128/mBio.00775-13 |url=}} 9. ^{{cite journal |vauthors=Zhu H, Wan X, Li J, Han L, Bo X, Chen W, Lu C, Shen Z, Xu C, Chen L, Yu C, Xu G |title=Computational Prediction and Validation of BAHD1 as a Novel Molecule for Ulcerative Colitis |journal=Sci Rep |volume=Jul 17 |issue=5:12227|pages= |year=2015 |doi=10.1038/srep12227 |pmid=26183847 |url=}} Further reading{{refbegin | 2}}
1 : Human proteins |
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