词条 | BT-20 |
释义 |
BT-20 is a breast cancer cell line derived from a 74-year-old human female in 1958 by E.Y. Lasfargues and L. Ozzello.[1] The cells technically came from a triple-negative breast cancer, which was caused by an invasive ductal carcinoma in the mammary gland. BT-20 cells are known to have amplified regions of chromosomes 6, 11, and 20, with most cells being hyperdiploid.[2] The cells express an estrogen receptor with a deletion of exon 5, and are used in preclinical studies of breast cancer. References1. ^{{cite journal |first1=EY|last1=Lasfargues|first2=L|last2=Ozzello|title = Cultivation of human breast carcinomas |journal=Journal of the National Cancer Institute|volume= 21|issue= 6|pages= 1131–1147 |year= 1958 |pmid= 13611537}} 2. ^{{cite web|url=http://www.pawefish.path.cam.ac.uk/BreastCellLineDescriptions/BT20.html|title=BT20|publisher=pawefish.uk|access-date=10 April 2018}} External links
1 : Human cell lines |
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