| 词条 | Butagest |
| 释义 |
| Verifiedfields = | Watchedfields = | verifiedrevid = | IUPAC_name = [(3S,8R,9S,10R,13S,14S,17R)-17-Acetyl-17-acetyloxy-6,10,13-trimethyl-1,2,3,8,9,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-yl] butanoate | image = Butagest.svg | width = 200px | tradename = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = | class = Progestogen; Progestogen ester | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = | CAS_number = | CAS_supplemental = | ATC_prefix = | ATC_suffix = | ATC_supplemental = | PubChem = 15816431 | IUPHAR_ligand = | DrugBank_Ref = | DrugBank = | ChemSpiderID_Ref = | ChemSpiderID = 21377535 | UNII = | KEGG = | ChEBI = | ChEMBL = | synonyms = Buterol; 17α-Acetoxy-3β-butanoyloxy-6-methyl-pregna-4,6-dien-20-one; 17α-Acetoxy-6-methyl-20-oxopregna-4,6-dien-3β-yl butyrate; 6-Methyl-17α-hydroxy-δ6-progesterone 3β-butanoate 17α-acetate | C=28 | H=40 | O=5 | SMILES = CCCC(=O)O[C@H]1CC[C@@]2([C@H]3CC[C@]4([C@H]([C@@H]3C=C(C2=C1)C)CC[C@@]4(C(=O)C)OC(=O)C)C)C | StdInChI_Ref = | StdInChI = 1S/C28H40O5/c1-7-8-25(31)32-20-9-12-26(5)22-10-13-27(6)23(21(22)15-17(2)24(26)16-20)11-14-28(27,18(3)29)33-19(4)30/h15-16,20-23H,7-14H2,1-6H3/t20-,21+,22-,23-,26+,27-,28-/m0/s1 | StdInChIKey_Ref = | StdInChIKey = VWKIFEBMJRFARL-NAEKRLSBSA-N }} Butagest, also known as buterol,[1] as well as 3β-hydroxy-6-methyl-17α-hydroxypregna-4,6-dien-20-one 3β-butanoate 17α-acetate or as 6-methyl-17α-hydroxy-δ6-progesterone 3β-butanoate 17α-acetate, is a steroidal progestin which was developed in Russia for potential clinical use but was never marketed.[2][3][4][5][6] It is a modification of megestrol acetate in which the C3 ketone has been replaced with a C3β butanoyloxy moiety. See also
References1. ^{{cite journal | vauthors = Fedotcheva TA, Kruglov AG, Teplova VV, Fedotcheva NI, Rzheznikov VM, Shimanovskiĭ NL | title = [Effect of steroid hormones on production of reactive oxygen species in mitochondria] | journal = Biofizika | volume = 57 | issue = 6 | pages = 1014–9 | year = 2012 | pmid = 23272582 | doi = | url = }} {{Progesterone receptor modulators}}{{steroid-stub}}{{genito-urinary-drug-stub}}2. ^{{cite journal |vauthors=Sergeev PV, Semeĭkin AV, Smirnova ZS, et al. |title=[Antitumor activity of the new gestagen 17alpha-acetoxy-3beta-butanoyloxy-6-methyl-pregna-4,6-dien-20-one] |journal=Eksp Klin Farmakol |volume=67 |issue=4 |pages=54–6 |year=2004 |pmid=15500049 |doi= |url=}} 3. ^{{cite journal |vauthors=Tapil'skaia NI, Petrosian MA, Lesik EA |title=[Therapeutic efficacy of novel 17alpha-hydroxyprogesterone derivatives in experimental preterm labor] |journal=Eksp Klin Farmakol |volume=65 |issue=1 |pages=44–5 |year=2002 |pmid=12025785 |doi= |url=}} 4. ^Fedotcheva, T. A., Semeykin, A. V., Schimanowsky, N. L., & Rzheznikov, V. M. (2004, July). New progestin butagest is a perspective antiproliferative agent and chemosensitizer. In FUNDAMENTAL & CLINICAL PHARMACOLOGY (Vol. 18, pp. 84-84). 111 RIVER ST, HOBOKEN 07030-5774, NJ USA: WILEY-BLACKWELL. 5. ^{{cite journal |vauthors=Korkhov VV, Lesik EA, Petrosian MA |title=[Gestagenic and contraceptive activity of new synthetic progesterone analogs in experimental animals] |journal=Eksp Klin Farmakol |volume=68 |issue=1 |pages=39–41 |year=2005 |pmid=15786963 |doi= |url=}} 6. ^{{cite journal |vauthors=Kareva EN, Grinenko GS, Gasparian ND, Ovchinnikova EV, Gorenkova OS |title=[Influence of the structure of synthetic gestagens on their binding to progesteron receptors in the endometrium] |journal=Eksp Klin Farmakol |volume=69 |issue=4 |pages=36–8 |year=2006 |pmid=16995436 |doi= |url=}} 8 : Acetate esters|Butyrate esters|Ketones|Pregnanes|Prodrugs|Progestogen esters|Progestogens|Russian drugs |
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