| 词条 | BzODZ-EPyr |
| 释义 |
| IUPAC_name = 3-(3-Benzyl-1,2,4-oxadiazol-5-yl)-1-[2-(pyrrolidin-1-yl)ethyl]-1H-indole | image = BzODZ-EPyr.svg | width = 100px | tradename = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = Schedule II | legal_UK = | legal_US = | legal_status = | routes_of_administration = | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number = | ATC_prefix = | ATC_suffix = | PubChem = 9842447 | ChemSpiderID = 8018162 | ChEMBL = 463656 | C=23 | H=24 | N=4 | O=1 | molecular_weight = | StdInChI = 1S/C23H24N4O/c1-2-8-18(9-3-1)16-22-24-23(28-25-22)20-17-27(15-14-26-12-6-7-13-26)21-11-5-4-10-19(20)21/h1-5,8-11,17H,6-7,12-16H2 | StdInChIKey = RUVOQWMACBDQDK-UHFFFAOYSA-N | smiles = C(C1=CC=CC=C1)C2=NOC(=N2)C3=C[N](C4=CC=CC=C34)CCN5CCCC5 }}BzODZ-EPyr is an indole based synthetic cannabinoid that has been sold as a designer drug in Russia.[1] It acts as a CB1 receptor agonist with a pKB value of 7.2 and demonstrates that replacing the ketone in 3-carbonylindoles with an oxadiazole spacer does generally not lead to activity loss.[2][3] See also{{colbegin}}
References1. ^{{cite journal|first1=Vadim|last1=Shevyrin|first2=Vladimir|last2=Melkozerov|first3=Oleg|last3=Eltsov|first4=Yuri|last4=Shafran|title=Synthetic cannabinoid 3-benzyl-5-[1-(2-pyrrolidin-1-ylethyl)-1H-indol-3-yl]-1,2,4-oxadiazole. The first detection in illicit market of new psychoactive substances|url=http://www.sciencedirect.com/science/article/pii/S0379073815005204|journal=Forensic Science International|date=February 2016|pages=95–100|volume=259|doi=10.1016/j.forsciint.2015.12.019|pmid=26771874|first5=Yuri|last5=Morzherin}} {{Cannabinoids}}{{cannabinoid-stub}}2. ^{{cite journal|first1=Gerard P.|last1=Moloney|first2=James A.|last2=Angus|first3=Alan D.|last3=Robertson|first4=Martin J.|last4=Stoermer|title=Synthesis and cannabinoid activity of 1-substituted-indole-3-oxadiazole derivatives: Novel agonists for the CB1 receptor|url=http://www.sciencedirect.com/science/article/pii/S022352340700195X|journal=European Journal of Medicinal Chemistry|date=March 2008|pages=513–539|volume=43|issue=3|doi=10.1016/j.ejmech.2007.04.007|pmid=17582659|first5=Michael|last5=Robinson|first6=Christine E.|last6=Wright|first7=Ken|last7=McRae|first8=Arthur|last8=Christopoulos}} 3. ^{{citation|first1=Peter Gerard|last1=Moloney|first2=Alan Duncan|last2=Robertson|title=Patent US6930118 - 3-Oxadiazol-5-yl-1-aminoalkyl-1h-indole derivatives|work=Amrad Operations Pty. Ltd.|url=https://www.google.com/patents/US6930118|date=2005}} 5 : Cannabinoids|Designer drugs|Indoles|Oxadiazoles|Pyrrolidines |
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