| 词条 | C3orf67 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 释义 |
Chromosome 3 open reading frame 67 or C3orf67 is a protein that in humans is encoded by the gene C3orf67.[1][2] The function of C3orf67 is not yet fully understood. GeneC3orf67 is located at 3p14.2 on the reverse strand ranging from 58716417-59050045 base pairs.[3][1] The accession number is NP_001338459.1.[4]ProteinPrimary sequence and isoformsThe coding sequence is 402-2681 base pairs of 3135 base pairs,[3] making up 759 amino acids.[1][4] C3orf67 has six validated isoforms.[1] Isoform one is the most complete with 16 exons.[3] C3orf67 weighs 84.35 kilodaltons.[5] Domains and motifsThere are three functional domains identified for C3orf67[6]
Post-translational modificationsSeveral post-translational modifications have been predicted for C3orf67 in conserved regions using various bioinformatic prediction tools[7][8][9][10][11][12][13][14]
Secondary structureThe beginning of C3orf67 is predicted to consist of a series of beta strands and a couple alpha helices that coincide with the DUF667 domain. There are also alpha helices predicted in regions that correspond to the CM_mono2 and OCRE domains.[15][16][17] Tertiary structureThe DUF667 region is predicted to form a tube like structure from a series of beta sheets.[17] Homology and EvolutionParalogsThere are no known paralogs of C3orf67. OrthologsOrthologs have been identified for C3orf67 in species ranging from fungus, plants, hemichordates, parasites, fish, reptiles, birds, invertebrates, and mammals.
Distant homologs
ExpressionPromoterThe promoter is well conserved across humans, gibbons, baboons, orangutans, cats, squirrels, alpacas, rabbits and mice.[18] There are several high quality transcription factor binding sites.[26] There are also several stem loop structures that are predicted to be formed in the promoter region.[19] A couple of which overlap with transcription factor binding sites. ExpressionC3orf67 is prominently expressed in the liver, tonsils, trachea, ovaries, testis, placenta, and colon. In other tissues it is expressed at low levels.[20] An increase in expression has been linked to small cell lung cancer.[21]FunctionThe protein has been identified as one of seventeen (17) genes that may play a novel role in the intersection of tumor promotion and DNA damaging stress and may be linked to carcinogenesis.[22] Interacting ProteinsTranscription factorsThere are three notable transcription factors that are known to be involved in the regulation of cell growth or immune responses:
Other interacting proteinsSeveral other proteins have been predicted to interact with C3orf67:
References1. ^1 2 3 {{Cite web|url=https://www.ncbi.nlm.nih.gov/gene?LinkName=nuccore_gene&from_uid=1191017729|title=NCBI Gene|last=|first=|date=|website=National Center for Biotechnology Information|archive-url=|archive-date=|dead-url=|access-date=}} 2. ^{{Cite web|url=https://www.genecards.org/cgi-bin/carddisp.pl?gene=C3orf67|title=C3orf67|last=|first=|date=|website=GeneCards Human Gene Database|archive-url=|archive-date=|dead-url=|access-date=}} 3. ^1 2 {{Cite web|url=https://www.ncbi.nlm.nih.gov/nuccore/NM_001351530.1|title=NCBI Nucleotide|last=|first=|date=|website=National Center for Biotechnology Information|archive-date=|dead-url=|access-date=}} 4. ^1 {{Cite web|url=https://www.ncbi.nlm.nih.gov/protein/NP_001338459.1|title=NCBI Protein|last=|first=|date=|website=National Center for Biotechnology Information|archive-url=|archive-date=|dead-url=|access-date=}} 5. ^{{Cite web|url=https://www.sciencegateway.org/tools/proteinmw.htm|title=Protein Molecular Weight Calculator|website=www.sciencegateway.org|access-date=2018-02-25}} 6. ^{{Cite web|url=http://www.genome.jp/tools/motif/|title=MOTIF: Searching Protein Sequence Motifs|website=www.genome.jp|access-date=2018-02-25}} 7. ^{{Cite web|url=http://www.cbs.dtu.dk/services/DictyOGlyc/|title=DictyOGlyc 1.1 Server|website=www.cbs.dtu.dk|language=en|access-date=2018-04-30}} 8. ^{{Cite web|url=http://sumosp.biocuckoo.org/online.php|title=GPS-SUMO: Prediction of SUMOylation Sites & SUMO-interaction Motifs|website=sumosp.biocuckoo.org|access-date=2018-04-30}} 9. ^{{Cite web|url=https://web.expasy.org/sulfinator/|title=ExPASy - Sulfinator tool|website=web.expasy.org|language=en-US|access-date=2018-04-30}} 10. ^{{Cite web|url=http://www.abgent.com/sumoplot|title=SUMOplot™ Analysis Program {{!}} Abgent|website=www.abgent.com|language=en|access-date=2018-04-30}} 11. ^{{Cite web|url=https://www.phosphosite.org/proteinAction.action?id=2264321&showAllSites=true|title=C3orf67 (human)|website=www.phosphosite.org|access-date=2018-04-30}} 12. ^{{Cite web|url=http://www.cbs.dtu.dk/services/NetOGlyc/|title=NetOGlyc 4.0 Server|website=www.cbs.dtu.dk|language=en|access-date=2018-04-30}} 13. ^{{Cite web|url=http://www.cbs.dtu.dk/services/YinOYang/|title=YinOYang 1.2 Server|website=www.cbs.dtu.dk|language=en|access-date=2018-04-30}} 14. ^{{Cite web|url=http://www.cbs.dtu.dk/services/NetPhos/|title=NetPhos 3.1 Server|website=www.cbs.dtu.dk|language=en|access-date=2018-04-30}} 15. ^{{Cite web|url=http://www.compbio.dundee.ac.uk/jpred/|title=JPred: A Protein Secondary Structure Prediction Server|website=www.compbio.dundee.ac.uk|language=en|access-date=2018-04-24}} 16. ^{{Cite web|url=http://www.sbg.bio.ic.ac.uk/phyre2/html/page.cgi?id=index|title=PHYRE2 Protein Fold Recognition Server|last=Kelley|first=Lawrence|website=www.sbg.bio.ic.ac.uk|access-date=2018-04-24}} 17. ^1 {{Cite web|url=https://swissmodel.expasy.org/interactive|title=SWISS-MODEL {{!}} Workspace|website=swissmodel.expasy.org|language=en|access-date=2018-04-24}} 18. ^{{Cite web|url=https://genome.ucsc.edu/cgi-bin/hgBlat|title=Human BLAT Search|website=genome.ucsc.edu|access-date=2018-04-24}} 19. ^{{Cite web|url=http://unafold.rna.albany.edu/?q=mfold/rna-folding-form|title=RNA Folding Form {{!}} mfold.rit.albany.edu|website=unafold.rna.albany.edu|language=en|access-date=2018-05-02}} 20. ^{{cite journal | vauthors = Dezso Z, Nikolsky Y, Sviridov E, Shi W, Serebriyskaya T, Dosymbekov D, Bugrim A, Rakhmatulin E, Brennan RJ, Guryanov A, Li K, Blake J, Samaha RR, Nikolskaya T | title = A comprehensive functional analysis of tissue specificity of human gene expression | journal = BMC Biology | volume = 6 | pages = 49 | date = November 2008 | pmid = 19014478 | pmc = 2645369 | doi = 10.1186/1741-7007-6-49 }} 21. ^{{cite journal | vauthors = Sato T, Kaneda A, Tsuji S, Isagawa T, Yamamoto S, Fujita T, Yamanaka R, Tanaka Y, Nukiwa T, Marquez VE, Ishikawa Y, Ichinose M, Aburatani H | title = PRC2 overexpression and PRC2-target gene repression relating to poorer prognosis in small cell lung cancer | language = En | journal = Scientific Reports | volume = 3 | issue = 1 | pages = 1911 | date = 2013-05-29 | pmid = 23714854 | pmc = 3665955 | doi = 10.1038/srep01911 | url = http://www.nature.com/articles/srep01911 }} 22. ^{{cite journal | vauthors = Glover KP, Chen Z, Markell LK, Han X | title = Synergistic Gene Expression Signature Observed in TK6 Cells upon Co-Exposure to UVC-Irradiation and Protein Kinase C-Activating Tumor Promoters | journal = PloS One | volume = 10 | issue = 10 | pages = e0139850 | date = 2 October 2015 | pmid = 26431317 | pmc = 4592187 | doi = 10.1371/journal.pone.0139850 }} 23. ^1 {{Cite web|url=https://www.genomatix.de/cgi-bin/matbase/matbase.pl?s=ef479d78b72cd422e7b38360cea871c4;NAME=MATRIXID_41a78c8600cf8a089c042a11aacd2ef7;ML=110|title=Genomatix: Matrix Library information|website=www.genomatix.de|language=en-US|access-date=2018-04-24}} 24. ^{{cite journal | vauthors = Zawel L, Dai JL, Buckhaults P, Zhou S, Kinzler KW, Vogelstein B, Kern SE | title = Human Smad3 and Smad4 are sequence-specific transcription activators | journal = Molecular Cell | volume = 1 | issue = 4 | pages = 611–7 | date = March 1998 | pmid = 9660945 | doi = 10.1016/S1097-2765(00)80061-1 }} 25. ^{{Cite web|url=https://www.genomatix.de/cgi-bin/matbase/matbase.pl?s=ef479d78b72cd422e7b38360cea871c4;NAME=MATRIXID_333a51744ffdaf7158e710eeafb0ff9d;ML=110|title=Genomatix: Matrix Library information|website=www.genomatix.de|language=en-US|access-date=2018-04-24}} 26. ^{{cite journal | vauthors = Treiber T, Mandel EM, Pott S, Györy I, Firner S, Liu ET, Grosschedl R | title = Early B cell factor 1 regulates B cell gene networks by activation, repression, and transcription- independent poising of chromatin | journal = Immunity | volume = 32 | issue = 5 | pages = 714–25 | date = May 2010 | pmid = 20451411 | doi = 10.1016/j.immuni.2010.04.013 }} 27. ^{{Cite web|url=https://www.genomatix.de/cgi-bin/matbase/matbase.pl?s=ef479d78b72cd422e7b38360cea871c4;NAME=MATRIXID_4727fdb43b1487897e8922c5900f1d08;ML=110|title=Genomatix: Matrix Library information|website=www.genomatix.de|language=en-US|access-date=2018-04-24}} 28. ^{{cite journal | vauthors = Molnár A, Georgopoulos K | title = The Ikaros gene encodes a family of functionally diverse zinc finger DNA-binding proteins | journal = Molecular and Cellular Biology | volume = 14 | issue = 12 | pages = 8292–303 | date = December 1994 | pmid = 7969165 | pmc = 359368 | doi = 10.1128/MCB.14.12.8292 }} 29. ^{{cite journal | vauthors = Lipp JJ, Marvin MC, Shokat KM, Guthrie C | title = SR protein kinases promote splicing of nonconsensus introns | language = En | journal = Nature Structural & Molecular Biology | volume = 22 | issue = 8 | pages = 611–7 | date = August 2015 | pmid = 26167880 | doi = 10.1038/nsmb.3057 | url = http://www.nature.com/articles/nsmb.3057 }} 30. ^{{Cite web|url=https://www.antibodypedia.com/gene/34923/CLK1|title=Antibodypedia - CLK1 antibodies|website=www.antibodypedia.com|access-date=2018-05-01}} 31. ^{{cite journal | vauthors = Mikolcevic P, Sigl R, Rauch V, Hess MW, Pfaller K, Barisic M, Pelliniemi LJ, Boesl M, Geley S | title = Cyclin-dependent kinase 16/PCTAIRE kinase 1 is activated by cyclin Y and is essential for spermatogenesis | journal = Molecular and Cellular Biology | volume = 32 | issue = 4 | pages = 868–79 | date = February 2012 | pmid = 22184064 | pmc = 3272973 | doi = 10.1128/MCB.06261-11 | url = http://mcb.asm.org/content/32/4/868 }} 32. ^{{Cite web|url=https://www.antibodypedia.com/gene/374/CDK16|title=Antibodypedia - CDK16 antibodies|website=www.antibodypedia.com|access-date=2018-05-01}} 33. ^1 {{cite journal | vauthors = van Meel E, Wegner DJ, Cliften P, Willing MC, White FV, Kornfeld S, Cole FS | title = Rare recessive loss-of-function methionyl-tRNA synthetase mutations presenting as a multi-organ phenotype | journal = BMC Medical Genetics | volume = 14 | pages = 106 | date = October 2013 | pmid = 24103465 | pmc = 3852179 | doi = 10.1186/1471-2350-14-106 }} 34. ^1 {{Cite web|url=https://string-db.org/cgi/network.pl?taskId=76hl8pAxLuaX|title=STRING: functional protein association networks|website=string-db.org|language=en|access-date=2018-05-01}} 35. ^{{cite journal | vauthors = Cornen S, Guille A, Adélaïde J, Addou-Klouche L, Finetti P, Saade MR, Manai M, Carbuccia N, Bekhouche I, Letessier A, Raynaud S, Charafe-Jauffret E, Jacquemier J, Spicuglia S, de The H, Viens P, Bertucci F, Birnbaum D, Chaffanet M | title = Candidate luminal B breast cancer genes identified by genome, gene expression and DNA methylation profiling | journal = PloS One | volume = 9 | issue = 1 | pages = e81843 | date = 2014-01-09 | pmid = 24416132 | pmc = 3886975 | doi = 10.1371/journal.pone.0081843 }} |
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