| 词条 | C9orf50 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 释义 |
Chromosome 9 open reading frame 8 is a protein that in humans is encoded by the C9orf50 gene.[1] This protein has a function that is not yet very well understood by the scientific community. C9orf50 has one other known alias, FLJ35803.[2] In humans the gene coding sequence is 10,051 base pairs long, transcribing an mRNA of 1,624 bases that encodes a 431 amino acid protein. GeneIn humans the gene is located on the minus strand at 9q34.11 and the coding sequence is 8,552 base pairs long.[3] In the neighborhood of C9orf50 is NTMT1 gene.[4] This gene is made up of 7 exons. On human chromosome 9, the gene spans bases chr9:132,374,504-132,383,055[5] TranscriptThe C9orf50 gene has isoforms X1-X11.[5] ProteinThe C9orf50 protein has a molecular weight of 47,639 Da and consists 431 amino acids.[3] The C9orf50 protein contains the conserved domain in pfam15737- DUF4685, the function of which is not well understood and conserved in vertebrates. HomologsThere are no known paralogs of C9orf50. Homologs of C9orf50 have been found conserved across all subclasses of mammals.[6] This gene is not found in reptiles, amphibians, birds, or any other organisms evolved before mammals. A list of mammals in which C9orf50 is conserved is shown below.
References1. ^{{Cite web|url=https://www.ncbi.nlm.nih.gov/protein/NP_955382.3|title=uncharacterized protein C9orf50 [Homo sapiens] - Protein - NCBI|website=www.ncbi.nlm.nih.gov|access-date=2019-02-25}} 2. ^{{Cite web|url=https://uswest.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000179058;r=9:129612225-129620776|title=Gene: C9orf50 (ENSG00000179058) - Summary - Homo sapiens - Ensembl genome browser 95|website=uswest.ensembl.org|access-date=2019-02-25}} 3. ^1 {{Cite web|url=https://www.genecards.org/cgi-bin/carddisp.pl?gene=C9orf50&keywords=c9orf50|title=C9orf50 Gene|last=|first=|date=|website=www.genecards.org|archive-url=|archive-date=|dead-url=|access-date=2019-02-25}} 4. ^{{Cite web|url=https://genecards.weizmann.ac.il/geneloc-bin/display_map.pl?chr_nr=9&range_type=gc_id&gc_id=GC09M129612#GC09M129612|title=GeneLoc map region for Chromosome 9 (127,612,225 - 131,622,275 bp) around "C9orf50"|last=|first=|date=|website=GeneLoc|archive-url=|archive-date=|dead-url=|access-date=}} 5. ^1 {{Cite web|url=https://www.ncbi.nlm.nih.gov/gene?cmd=retrieve&list_uids=375759|title=C9orf50 chromosome 9 open reading frame 50 [Homo sapiens (human)] - Gene - NCBI|website=www.ncbi.nlm.nih.gov|access-date=2019-02-25}} 6. ^{{Cite web|url=https://blast.ncbi.nlm.nih.gov/Blast.cgi?PAGE=Proteins&PROGRAM=blastp&BLAST_PROGRAMS=blastp&LINK_LOC=protein&PAGE_TYPE=BlastSearch&QUERY=|title=Protein BLAST: search protein databases using a protein query|website=blast.ncbi.nlm.nih.gov|access-date=2019-02-25}} |
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