| 词条 | Carboxyatractyloside |
| 释义 |
| Name = Carboxyatractyloside | OtherNames = CATR | ImageFile = Carboxyatractyloside.svg | Section1 = {{Chembox Identifiers | ChemSpiderID = 16737649 | PubChem = 20055804 | CASNo = 33286-30-5 | DrugBank = DB02426 | EC_number = 251-444-9 | UNII = SNP1XL23E6 | StdInChI=1S/C31H46O18S2/c1-14(2)9-21(33)47-24-23(49-51(42,43)44)22(48-50(39,40)41)18(13-32)46-26(24)45-17-11-29(4)19-6-5-16-10-30(19,25(34)15(16)3)8-7-20(29)31(12-17,27(35)36)28(37)38/h14,16-20,22-26,32,34H,3,5-13H2,1-2,4H3,(H,35,36)(H,37,38)(H,39,40,41)(H,42,43,44)/t16-,17+,18-,19+,20+,22-,23+,24-,25+,26-,29+,30-/m1/s1 | StdInChIKey = AQFATIOBERWBDY-LNQSNDDKSA-N | SMILES = CC(CC(=O)O[C@H]1[C@@H](O[C@@H]([C@H]([C@@H]1OS(=O)(=O)O)OS(=O)(=O)O)CO)O[C@@H]2C[C@@]([C@@H]3[C@@](C2)([C@H]4[C@@]5([C@H](C(=C)[C@@H](C5)CC4)O)CC3)C)(C(=O)O)C(=O)O)C }} | Section2 = {{Chembox Properties | C=31|H=46|O=18|S=2 }} }}Carboxyatractyloside (CATR) is a highly toxic diterpene glycoside that inhibits the ADP/ATP translocase. It's about 10 times more potent than atractyloside.[1] While atractyloside is effective in the inhibition of oxidative phosphorylation, carboxyatractyloside is considered to be more effective. As well when carboxyatractyloside is inhibited, it is not reversed by increasing the concentration of adenine nucleotides unlike its counterpart atractyloside. Carboxyatractyloside behavior resembles bongkrekic acid while in the mitochondria.[2] References1. ^{{cite journal | vauthors = Kedrov A, Hellawell AM, Klosin A, Broadhurst RB, Kunji ER, Müller DJ | title = Probing the interactions of carboxy-atractyloside and atractyloside with the yeast mitochondrial ADP/ATP carrier | journal = Structure | volume = 18 | issue = 1 | pages = 39–46 | date = January 2010 | pmid = 20152151 | doi = 10.1016/j.str.2009.11.009 }} {{Organic-compound-stub}}{{Biochem-stub}}2. ^{{cite journal | vauthors = Luciani S, Martini N, Santi R | title = Effects of carboxyatractyloside a structural analogue of atractyloside on mitochondrial oxidative phosphorylation | journal = Life Sciences | volume = 10 | issue = 17, Pt 2 | pages = 961–8 | date = September 1971 | pmid = 4255019 | doi = 10.1016/0024-3205(71)90099-3 }} 8 : Diterpene glycosides|ADP/ATP translocase inhibitors|Alcohols|Alkenes|Carboxylic acids|Organosulfates|Plant toxins|Poisons |
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