请输入您要查询的百科知识：

　

词条 Catherine Woolley (scientist)
释义

  1. Early life

  2. Career

  3. Research

     Rockefeller University  University of Washington   Northwestern University 

  4. Awards and honors

  5. References

{{Infobox scientist
|name = Catherine S. Woolley
|image =
|image_size =
|caption =
|birth_date = {{birth date and age|1965|07|30|mf=yes}}
|birth_place = Nelsonville, Ohio
|nationality =
|death_date =
|death_place =
|field =
|work_institution = Northwestern University, University of Washington
|alma_mater = Rockefeller University, Texas A&M University
|doctoral_advisor = Bruce McEwen
|doctoral_students =
|known_for = Neurobiology and neurology
|prizes =
|footnotes =
}}Catherine S. Woolley (born July 30, 1965) is an American neuroendocrinologist. Woolley holds the William Deering Chair in Biological Sciences in the Department of Neurobiology, Weinberg College of Arts & Sciences, at Northwestern University.[1][2]

She is also a member of the Women's Health Research Institute in the Feinberg School of Medicine at Northwestern University.[3]

Woolley studies cellular and molecular neuroscience in relation to the brain and behavior, particularly neuroendocrinology and the plasticity of neural circuits.[1]

She attempts to understand molecular mechanisms of estrogen and its interactions with the structure and function of synapses in the adult brain, and their behavioral consequences.[5]

She has been described as "a leading authority in a very exciting area of adult neuroplasticity".[6]

Her earliest work included a pioneering study demonstrating that estrogen caused structural changes to cells in the rat hippocampus.[7] She has also shown that neuronal mechanisms in the rat brain differ in males and females. Her work has broad significance for drug development and women's health,[8] and for the studies of epilepsy,[4] anxiety[1][5] and depression.[6]

Early life

Catherine S. Woolley was born on July 30, 1965, in Nelsonville, Ohio. She graduated from Texas A&M University in College Station, Texas, with a B.Sc. honors in zoology[7] and was given a prize by the university for the best undergraduate honors thesis.[8]

Career

Woolley studied with Bruce McEwen at Rockefeller University, receiving her Ph.D. from Rockefeller in 1993.[2][9]

She did postdoctoral work at the University of Washington with Philip Schwartzkroin in the Department of Neurological Surgery.[2]

In 1998, she became an assistant professor at Northwestern University in New York.[2] In 2013, Woolley was appointed to the William Deering Chair in Biological Sciences in the Department of Neurobiology, Weinberg College of Arts & Sciences, Northwestern University.[1] She is the founding Director of Northwestern University's undergraduate Neuroscience program, and was named a Charles Deering McCormick Professor of Teaching Excellence by Northwestern in 2018 for "transforming the landscape of undergraduate education in Weinberg."[10]

She was elected to the Council of the Society for Neuroscience (2014–2018).[11] She is a senior editor of The Journal of Neuroscience.[12]

Research

Rockefeller University

Bruce McEwen at Rockefeller University studies stress and its impact on the brain.[23]

With McEwen, Woolley initially studied neuroleptics and their effects on proenkephalin mRNA levels.[7]

Woolley went on to work with McEwen and Elizabeth Gould on a 1990 study that examined the brain using Golgi's method,[7][7][27] a technique first described by Camillo Golgi in 1873.[13]

The study showed that estradiol increased the number and density of excitatory synapses of CA1 pyramidal cells in the rat hippocampus, as well as the density of dendritic spines. Both estradiol and spine density fluctuated dramatically during the estrous cycle.[7][7][14] Woolley recognized that this suggested that the adult brain was subject to change, at least in rats; this was surprising because it was accepted at that time that the adult brain was structurally stable.[7][9][15] Woolley's 1990 work is considered a pioneering study in hormones and synaptic plasticity.[16]

Further work established that the manipulation of female

sex hormones affects hippocampal structure in adult rats.[16][17]

University of Washington

Between 1993-1998, Woolley worked as a postdoc at the University of Washington in Seattle, with Philip Schwartzkroin. There she applied electrophysiology techniques and ultrastructural analysis to the study of hormonal effects in the brain.[7][18][19] She studied the effects of estrogen on the release of GABA in the hippocampus.[20]

In 2000, she received the Cortical Explorer Award in recognition of her work on neuroanatomy and brain activity.[7]

{{quote|"Catherine is finding the same neuronotrophic activation by steroids whether she uses Golgi staining to count spines or the electron microscope to visualize synapses. The methods are more sophisticated and powerful, but the basic observation is the same." Cortical Explorer Award, 2000[7]}}

Northwestern University

As a professor at Northwestern University,

Woolley has done ongoing research into the sex-specific effects of estrogens, GABAA receptors, metabotropic glutamate receptors, and endogenous cannabinoids and their roles as neuromodulators of brain development and function.[21][22][23]

In 2012, Woolley published research showing that estrogens had differential effects in the brains of female and male rats, decreasing inhibitory synaptic transmission in female rats but not in males.[3][24]

In 2015, her group reported that male and female rats differ in the molecular pathways affected by endocannabinoids. In female rats the drug URB-597 increased the inhibitory effect of the endocannabinoid anandamide, lessening the release of neurotransmitters. In male rats, the drug had no effect. The interaction did not reflect circulating reproductive hormones.[3] Further research is needed to determine the extent to which rat neurology provides an accurate model for human neurology.[3][5]

While the significance of these results for humans are not yet demonstrated, rats are often used as a model for studying humans. An important implication of Woolley's research is that drug testing on males should not be assumed to yield results applicable to both males and females. To understand drug action, effects on both sexes should be studied.[3][25][5]

Awards and honors

  • 1998: Alfred P. Sloan Foundation Fellowship[7]
  • 2000: Cortical Explorer Award, Krieg Awards, Cajal Club[7]
  • 2002–2007: W. M. Keck Foundation Distinguished Young Scholar in Medical Research Award[26]
  • 2007: C.J. Herrick Award, American Association of Anatomists[27]
  • 2007–2009: Pioneer Award, Women's Health Research Institute, Northwestern University[28]
  • 2013: William Deering Chair in Biological Sciences, Northwestern University[1]
  • 2016: Transformative Research Award, National Institutes of Health[29][30]
  • 2018: Charles Deering McCormick Professor of Teaching Excellence, Northwestern University[10]

References

1. ^1 2 3 4 {{cite web |title=Catherine Woolley |url=https://www.neurobiology.northwestern.edu/people/core-faculty/catherine-woolley.html |website= Northwestern University |accessdate=29 September 2018}}
2. ^1 2 3 {{cite web |title=Brain Estrogens and Epilepsy: Evidence for latent sex differences in mechanisms of neuromodulation |url=https://fralin.vt.edu/VTLSS/fall-2018/7.html |website=Fralin Life Science Institute |publisher=Virginia Tech |accessdate=2 October 2018}}
3. ^1 2 3 4 {{cite news |title=Another Difference Between The Sexes Uncovered, Northwestern University Reveals |url=https://www.biospace.com/article/another-difference-between-the-sexes-uncovered-northwestern-university-reveals-/ |accessdate=1 October 2018 |work=Biospace |date=August 14, 2015}}
4. ^{{cite web |last1=Paul |first1=Marla |title=Researcher Explores Estrogen's Effect on Seizures May 8, 2007 |url=https://www.northwestern.edu/newscenter/stories/2007/05/epilepsy.html |website=Northweastern News |accessdate=3 October 2018}}
5. ^1 2 {{cite journal |last1=Shansky |first1=Rebecca M. |last2=Woolley |first2=Catherine S. |title=Considering Sex as a Biological Variable Will Be Valuable for Neuroscience Research |journal=The Journal of Neuroscience |date=23 November 2016 |volume=36 |issue=47 |pages=11817–11822 |doi=10.1523/JNEUROSCI.1390-16.2016 |pmid=27881768 |pmc=5125240 }}
6. ^{{cite book |last1=Lambert |first1=Kelly |title=Lifting depression : a neuroscientist's hands-on approach to activating your brain's healing power |date=2010 |publisher=Basic Books |isbn=978-0465018147 |pages=124–125 |url=https://books.google.com/books?id=6EIHhbEUVMEC&pg=PA124 |accessdate=3 October 2018}}
7. ^1 2 3 4 5 6 7 8 9 10 {{cite journal |last1=Azmitia |first1=Efrain C. |title=Krieg Cortical Kudos 2000 |url=https://academic.oup.com/cercor/article-pdf/10/8/826/9751081/100826.pdf |journal=Cerebral Cortex |date= 2000|volume=10|issue=8 |pages=826–828| doi= 10.1093/cercor/10.8.826 }}
8. ^{{cite news |last1=Stein |first1=Anne |title=Staying in STEM Encouraging Women to Persist in Math and Science |url=https://www.weinberg.northwestern.edu/after-graduation/weinberg-magazine/spring-summer-2014/staying-in-stem.html |accessdate=3 October 2018 |work=Weinberg College of Arts & Sciences |date=2014}}
9. ^1 {{cite book |editor-last1=Bear |editor-first1=Mark F. |editor-last2=Connors |editor-first2=Barry W. |editor-last3=Paradiso |editor-first3=Michael A. |title=Neuroscience : exploring the brain |date=2007 |publisher=Lippincott Williams & Wilkins |location=Baltimore, MD |isbn=978-1451109542 |edition=Fourth |chapter-url=https://books.google.com/books?id=75NgwLzueikC&pg=PA558 |chapter=Sex and the brain |journal=978-1451109542 |pages=555–558 }}
10. ^1 {{cite web |title=2018 Recipients |url=https://www.northwestern.edu/provost/faculty-honors/university-teaching-awards/award-recipients/2018.html#woolley |website=Northwestern University |accessdate=2 October 2018}}
11. ^{{cite web |title=Volunteer Leadership |url=http://auth.brainfacts.sfn.org/SfN/About/Volunteer-Leadership |website=Society for Neuroscience |accessdate=2 October 2018}}
12. ^{{cite web |title=2018 Editorial Board |url=http://www.jneurosci.org/content/editorial-board2 |website=The Journal of Neuroscience |accessdate=2 October 2018}}
13. ^{{Cite book|url=|title=Origins of neuroscience : a history of explorations into brain function|last=Finger|first=Stanley|publisher=Oxford University Press|year=1994|isbn=9780195146943|location=|pages=45|oclc=27151391|quote=In 1873, Golgi published the first brief but "adequate" picture of la reazione nera (the black reaction), which showed the whole nerve cell, including its cell body, axon, and branching dendrites.|via=}}
14. ^1 {{cite journal |last1=Woolley |first1=CS |last2=Gould |first2=E |last3=Frankfurt |first3=M |last4=McEwen |first4=BS |title=Naturally occurring fluctuation in dendritic spine density on adult hippocampal pyramidal neurons. |journal=The Journal of Neuroscience |date=December 1990 |volume=10 |issue=12 |pages=4035–9 |pmid=2269895 |doi=10.1523/JNEUROSCI.10-12-04035.1990 }}
15. ^1 {{cite journal |last1=McEwen |first1=Robert |title=When is stress good for you? |journal=AEON |date=11 July 2017 |url=https://aeon.co/essays/how-stress-works-in-the-human-body-to-make-or-break-us |accessdate=2 October 2018}}
16. ^1 2 3 4 {{cite book |last1=Garcia-Segura |first1=Luis Miguel |title=Hormones and brain plasticity |date=May 5, 2009 |publisher=Oxford University Press |isbn=9780195326611 |url=https://books.google.com/books?id=xzTiBwAAQBAJ&pg=PT107 |accessdate=1 October 2018}}
17. ^{{cite journal |last1=Gould |first1=Elizabeth |last2=Woolley |first2=Catherine S. |last3=Frankfurt |first3=Maya |last4=McEwen |first4=Bruce S. |title=Gonadal Steroids Regulate Dendritic Spine Density in Hippocampal Pyramidal Cells in Adulthood |journal=The Journal of Neuroscience |date=1990 |volume=10 |issue=4 |pages=1286–1291 |url=https://www.princeton.edu/~goulde/pubs/Gonadal%20steroids%20regulate%20dendritic%20spine%20density%20in%20hippocampal%20pyramidal%20cells%20in%20adulthood.pdf |accessdate=2 October 2018|doi=10.1523/JNEUROSCI.10-04-01286.1990 }}
18. ^{{cite journal |last1=Woolley |first1=CS |title=Electrophysiological and cellular effects of estrogen on neuronal function. |journal=Critical Reviews in Neurobiology |date=1999 |volume=13 |issue=1 |pages=1–20 |pmid=10223521 |doi=10.1615/CritRevNeurobiol.v13.i1.10 }}
19. ^{{cite journal |last1=Stafstrom |first1=Carl E. |title=Issues in Clinical Epileptology: A View from the Bench. A Festschrift in Honor of Philip A. Schwartzkroin, PhD |journal=Epilepsy Currents |date=December 2013 |volume=13 |issue=6 |pages=291–296 |doi=10.5698/1535-7597-13.6.291 |pmid=24348132 |pmc=3854749 }}
20. ^{{cite book |last1=Etgen |first1=Anne M. |last2=Pfaff |first2=Donald W. |title=Molecular mechanisms of hormone actions on behavior |date=2009 |publisher=Elsevier/Academic Press |isbn=978-0123749390 |page=43}}
21. ^{{cite journal |last1=Galanopoulou |first1=Aristea S. |title=Stirring the Pot With Estrogens |journal=Epilepsy Currents |date=May 2013 |volume=13 |issue=3 |pages=129–131 |doi=10.5698/1535-7511-13.3.129 |pmid=23840172 |pmc=3697880 }}
22. ^{{cite journal |last1=Spencer |first1=Joanna L. |last2=Waters |first2=Elizabeth M. |last3=Romeo |first3=Russell D. |last4=Wood |first4=Gwendolyn E. |last5=Milner |first5=Teresa A. |last6=McEwen |first6=Bruce S. |title=Uncovering the mechanisms of estrogen effects on hippocampal function |journal=Frontiers in Neuroendocrinology |date=May 2008 |volume=29 |issue=2 |pages=219–237 |doi=10.1016/j.yfrne.2007.08.006 |pmid=18078984 |pmc=2440702 }}
23. ^{{cite journal |last1=Wissman |first1=Anne Marie |last2=May |first2=Renee M. |last3=Woolley |first3=Catherine S. |title=Ultrastructural analysis of sex differences in nucleus accumbens synaptic connectivity |journal=Brain Structure and Function |date=11 October 2011 |volume=217 |issue=2 |pages=181–190 |doi=10.1007/s00429-011-0353-6 |pmid=21987050 |pmc=3275686 }}
24. ^{{cite journal |last1=Huang |first1=Guang Zhe |last2=Woolley |first2=Catherine S. |title=Estradiol Acutely Suppresses Inhibition in the Hippocampus through a Sex-Specific Endocannabinoid and mGluR-Dependent Mechanism |journal=Neuron |date=June 2012 |volume=74 |issue=5 |pages=801–808 |doi=10.1016/j.neuron.2012.03.035|pmid=22681685 |pmc=3372866 }}
25. ^1 {{cite web |last1=Shah |first1=Aparna |title=Sex differences in preclinical neuroscience research: Snippets from #SfN15 with Catherine Woolley |url=https://blogs.plos.org/neuro/2015/10/29/sex-differences-in-preclinical-neuroscience-research-snippets-from-sfn15-with-catherine-woolley-by-aparna-shah/ |website=PLOS Neuro Community |accessdate=3 October 2018|date= October 29, 2015}}
26. ^{{cite news |title=Keck Foundation Announces Completion of Distinguished Young Scholars Program |url=https://philanthropynewsdigest.org/news/keck-foundation-announces-completion-of-distinguished-young-scholars-program |accessdate=3 October 2018 |work=Philanthropy News Digest |date=December 24, 2009}}
27. ^{{cite web |title=Past & Current award Winners |url=https://www.anatomy.org/past-and-current-award-winners.html |website=AAmerican Association of Anatomists |accessdate=3 October 2018}}
28. ^{{cite web |title=Fellows & Scholars |url=https://www.womenshealth.northwestern.edu/fellows-scholars |website=Northwestern University |accessdate=3 October 2018|date=2014-12-19 }}
29. ^1 {{cite web |title=NIH Director's Transformative Research Award Recipients 2016 Awardees |url=https://commonfund.nih.gov/TRA/Recipients16 |website=National Institutes of Health |accessdate=3 October 2018}}
30. ^{{cite web |title=Faculty Honors and Awards |url=https://www.weinberg.northwestern.edu/faculty/career/recognition/honors/2016-2017-faculty-honors-awards.html |website=Northwestern University |accessdate=3 October 2018}}
{{Authority control}}{{DEFAULTSORT:Woolley, Catherine S.}}

10 : 1965 births|Living people|American women chemists|American neuroscientists|Women neuroscientists|21st-century American chemists|Northwestern University faculty|Texas A&M University alumni|Rockefeller University alumni|People from Nelsonville, Ohio
随便看

　

开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。

　

Copyright © 2023 OENC.NET All Rights Reserved
京ICP备2021023879号 更新时间：2024/11/11 19:07:10