| 释义 |
- Function
- References
- Further reading
{{Infobox_gene}}C-C motif chemokine ligand 27 is a protein that in humans is encoded by the CCL27 gene. [1]FunctionThis gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The protein encoded by this gene is chemotactic for skin-associated memory T lymphocytes. This cytokine may also play a role in mediating homing of lymphocytes to cutaneous sites. It specifically binds to chemokine receptor 10 (CCR10). Studies of a similar murine protein indicate that these protein-receptor interactions have a pivotal role in T cell-mediated skin inflammation. [provided by RefSeq, Sep 2014]. References 1. ^{{cite web| title = Entrez Gene: C-C motif chemokine ligand 27| url = https://www.ncbi.nlm.nih.gov/gene/10850| accessdate = 2018-03-23}}
Further reading {{refbegin | 30em}}- {{cite journal |vauthors=Mackay CR |title=New avenues for anti-inflammatory therapy |journal=Nat. Med. |volume=8 |issue=2 |pages=117–8 |date=February 2002 |pmid=11821893 |doi=10.1038/nm0202-117 |url=}}
- {{cite journal |vauthors=Homey B, Alenius H, Müller A, Soto H, Bowman EP, Yuan W, McEvoy L, Lauerma AI, Assmann T, Bünemann E, Lehto M, Wolff H, Yen D, Marxhausen H, To W, Sedgwick J, Ruzicka T, Lehmann P, Zlotnik A |title=CCL27-CCR10 interactions regulate T cell-mediated skin inflammation |journal=Nat. Med. |volume=8 |issue=2 |pages=157–65 |date=February 2002 |pmid=11821900 |doi=10.1038/nm0202-157 |url=}}
- {{cite journal |vauthors=Kakinuma T, Saeki H, Tsunemi Y, Fujita H, Asano N, Mitsui H, Tada Y, Wakugawa M, Watanabe T, Torii H, Komine M, Asahina A, Nakamura K, Tamaki K |title=Increased serum cutaneous T cell-attracting chemokine (CCL27) levels in patients with atopic dermatitis and psoriasis vulgaris |journal=J. Allergy Clin. Immunol. |volume=111 |issue=3 |pages=592–7 |date=March 2003 |pmid=12642842 |doi= |url=}}
- {{cite journal |vauthors=Hijnen D, De Bruin-Weller M, Oosting B, Lebre C, De Jong E, Bruijnzeel-Koomen C, Knol E |title=Serum thymus and activation-regulated chemokine (TARC) and cutaneous T cell- attracting chemokine (CTACK) levels in allergic diseases: TARC and CTACK are disease-specific markers for atopic dermatitis |journal=J. Allergy Clin. Immunol. |volume=113 |issue=2 |pages=334–40 |date=February 2004 |pmid=14767451 |doi=10.1016/j.jaci.2003.12.007 |url=}}
- {{cite journal |vauthors=Vestergaard C, Johansen C, Christensen U, Just H, Hohwy T, Deleuran M |title=TARC augments TNF-alpha-induced CTACK production in keratinocytes |journal=Exp. Dermatol. |volume=13 |issue=9 |pages=551–7 |date=September 2004 |pmid=15335355 |doi=10.1111/j.0906-6705.2004.00202.x |url=}}
- {{cite journal |vauthors=Hirata T, Furukawa Y, Yang BG, Hieshima K, Fukuda M, Kannagi R, Yoshie O, Miyasaka M |title=Human P-selectin glycoprotein ligand-1 (PSGL-1) interacts with the skin-associated chemokine CCL27 via sulfated tyrosines at the PSGL-1 amino terminus |journal=J. Biol. Chem. |volume=279 |issue=50 |pages=51775–82 |date=December 2004 |pmid=15466853 |doi=10.1074/jbc.M409868200 |url=}}
- {{cite journal |vauthors=Vestergaard C, Johansen C, Otkjaer K, Deleuran M, Iversen L |title=Tumor necrosis factor-alpha-induced CTACK/CCL27 (cutaneous T-cell-attracting chemokine) production in keratinocytes is controlled by nuclear factor kappaB |journal=Cytokine |volume=29 |issue=2 |pages=49–55 |date=January 2005 |pmid=15598438 |doi=10.1016/j.cyto.2004.09.008 |url=}}
- {{cite journal |vauthors=Spiekstra SW, Toebak MJ, Sampat-Sardjoepersad S, van Beek PJ, Boorsma DM, Stoof TJ, von Blomberg BM, Scheper RJ, Bruynzeel DP, Rustemeyer T, Gibbs S |title=Induction of cytokine (interleukin-1alpha and tumor necrosis factor-alpha) and chemokine (CCL20, CCL27, and CXCL8) alarm signals after allergen and irritant exposure |journal=Exp. Dermatol. |volume=14 |issue=2 |pages=109–16 |date=February 2005 |pmid=15679580 |doi=10.1111/j.0906-6705.2005.00226.x |url=}}
- {{cite journal |vauthors=Kagami S, Saeki H, Komine M, Kakinuma T, Nakamura K, Tsunemi Y, Sasaki K, Asahina A, Tamaki K |title=CCL28 production in HaCaT cells was mediated by different signal pathways from CCL27 |journal=Exp. Dermatol. |volume=15 |issue=2 |pages=95–100 |date=February 2006 |pmid=16433680 |doi=10.1111/j.1600-0625.2005.00390.x |url=}}
{{refend}}{{NLM content}}{{gene-9-stub}} |