“CD4+/CD8+ ratio”的意思、由来-开放百科全书

The CD4+/CD8+ ratio is the ratio of T helper cells (with the surface marker CD4) to cytotoxic T cells (with the surface marker CD8). CD4+ cells are anti-inflammatory, while CD8+ cells are pro-inflammatory.

The CD4+/CD8+ ratio in the peripheral blood of healthy adults and mice is about 2:1, and an altered ratio can indicate diseases relating to immunodeficiency or autoimmunity.^[1] An inverted CD4+/CD8+ ratio (namely, less than 1/1) indicates an impaired immune system.{{cn|date=October 2018}}

Decreased ratio

A reduced CD4+/CD8+ ratio is associated with reduced resistance to infection.^[2]

A declining CD4+/CD8+ ratio is associated with ageing, and is an indicator of immunosenescence.{{cn|date=October 2018}}

HIV infection leads to low levels of CD4⁺ T cells (lowering the CD4+/CD8+ ratio) through a number of mechanisms, including killing of infected CD4⁺ T cells by CD8 cytotoxic lymphocytes that productively infected cells.^[3] When CD4⁺ T cell numbers decline below a critical level, cell-mediated immunity is lost, and the body becomes progressively more susceptible to opportunistic infections.{{cn|date=October 2018}}

See also

References

1. ^{{Cite book|title=Kuby Immunology|last=Owen|first=Judith|last2=Punt|first2=Jenni|last3=Stranford|first3=Sharon|publisher=W. H. Freeman and Company|year=2013|isbn=|location=New York|pages=40|quote=}}
2. ^¹{{cite journal | vauthors=Yin Y, Qin J, Dai Y, Zeng F, Pei H, Wang J | title=The CD4+/CD8+ Ratio in Pulmonary Tuberculosis: Systematic and Meta-Analysis Article | journal= Iranian Journal of Public Health | volume=44 | issue=2 | pages=185–193 | year=2015 | pmc = 4401876 | pmid=25905052}}
3. ^{{cite book|last=Kumar|first=Vinay|title=Robbins Basic Pathology|year=2012|isbn=9781455737871|page=147|url=https://books.google.com/books?id=jheBzf17C7YC&pg=PA147|edition=9th}}