| 词条 | Chlorophenylsilatrane |
| 释义 |
| Name = Chlorophenylsilatrane | ImageFile = Chlorophenylsilatrane.svg | ImageSize = 100px | IUPACName = 1-(4-Chlorophenyl)-2,8,9-trioxa-5-aza-1-silabicyclo[3.3.3]undecane | OtherNames = RS-150 | Section1 = {{Chembox Identifiers | SMILES = c1cc(ccc1[Si]23OCCN(CCO2)CCO3)Cl | ChemSpiderID = 90808 | PubChem = 100508 | CASNo = 29025-67-0 | StdInChI=1S/C12H16ClNO3Si/c13-11-1-3-12(4-2-11)18-15-8-5-14(6-9-16-18)7-10-17-18/h1-4H,5-10H2 | StdInChIKey = IKFVTMCLFHXPQF-UHFFFAOYSA-N }} | Section2 = {{Chembox Properties | C=12|H=16|Cl=1|N=1|O=3|Si=1 }} | Section3 = {{Chembox Hazards | MainHazards = Extremely toxic | LD50 = 1.4 mg/kg (rats, oral) 0.9-2.0 mg/kg (mice, oral) }} }} Chlorophenylsilatrane is an extremely toxic organosilicon compound that was used as a rodenticide. Chlorophenylsilatrane was one of the toxic chemicals studied in the Project Coast.[1] ToxicityChlorophenylsilatrane is a GABA receptor antagonist.[2] It's a rapid acting convulsant, causing convulsions within 1 minute in mice and rats. Death occurred within 5 minutes.[3] See also
References1. ^{{cite web |title=Project Coast, Part One: The mad doctor and the forgotten rat poison |url=http://gliftor.typepad.com/blog/2011/01/project-coast-part-one-the-mad-doctor-and-the-forgotten-rat-poison.html |website=Toxic Terror}} {{Convulsants}}{{Chemical agents}}{{Neurotoxins}}{{Rodenticides}}{{GABA receptor modulators}}{{Neurotoxin-stub}}2. ^{{cite journal |last1=Casida |first1=JE |last2=Lawrence |first2=LJ |title=Structure-activity correlations for interactions of bicyclophosphorus esters and some polychlorocycloalkane and pyrethroid insecticides with the brain-specific t-butylbicyclophosphorothionate receptor |journal=Environmental Health Perspectives |date=September 1985 |volume=61 |pages=123–32 |pmid=2415350 |pmc=1568750}} 3. ^{{cite journal |last1=Greaves |first1=JH |last2=Redfern |first2=R |last3=Tinworth |first3=H |title=Laboratory tests of 5-p-chlorophenyl silatrane as a rodenticide |journal=The Journal of Hygiene |date=August 1974 |volume=73 |issue=1 |pages=39–43 |pmid=4529452 |pmc=4529452}} 10 : Convulsants|Organosilicon compounds|Nitrogen heterocycles|Oxygen heterocycles|Neurotoxins|Rodenticides|Chemical weapons|GABAA receptor negative allosteric modulators|Poisons|Chloroarenes |
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