1. Early life

2. Education

3. Research

4. Awards and honors

5. Key papers

6. References

7. External links

Early life

Christian Lüscher was born in Bern, Switzerland and grew up there as well as in the lake of Constance area.

Education

Lüscher studied medicine in Lausanne and Berne and obtained his federal diploma in 1990. In his MD degree, he studied the effects of axon morphology on action potential propagation. After clinical residencies at the Inselspital in Bern and the University Hopital in Geneva, he left for a postdoctoral fellowship at UCSF (Advisor Roger Nicoll). He returned to University of Geneva with a career development award of the Swiss National Science Foundation^[4], where he first became associated (2003) and then full professor (2009)^[5]

Research

Lüscher studies how addictive drugs alter synaptic transmission in the reward system of the mouse brain^[6]. He has proposed a mechansitic classification of addictive drugs and developed optogenetic stimulation protocols that when applied in a mouse model of addiction can erase adaptive behavior^[7]. In his most recent work he explores the molecular basis of individual vulnerability to addiction and launced several translational projects. He has initiated the OptoDBS conference series^[8], seeking to emulate optogenetic intervations with deep brain stimulation.

Awards and honors

• 2017 Théodore Ott Prize of Swiss Academy of Medical Sciences^[9]
• 2016 Betty and David Koetser Award for Brain Research^[10]
• 2015- Member American College of Neuropsychopharmacology
• 2015- Member Senate of Swiss Academy of Medical Sciences^[11]
• 2010 Cloëtta Prize^[12]

Key papers

Creed, M, Pascoli V, Lüscher C. Refining deep brain stimulation to emulate optogenetic treatment of synaptic pathology. Science. 2015, 347:659-64 [https://www.ncbi.nlm.nih.gov/pubmed/?term=Refining+deep+brain+stimulation+to+emulate+optogenetic+treatment+of+synaptic+pathology DOI:10.1126/science.1260776]

Pascoli V, Terrier J, Espallergues J, Valjent E, O'Connor EC, Lüscher C. Contrasting forms of cocaine-evoked plasticity control components of relapse. Nature. 2014, 509:459-64. [https://www.ncbi.nlm.nih.gov/pubmed/?term=Contrasting+forms+of+cocaine-evoked+plasticity+control+components+of+relapse DOI:10.1038/nature13257]

Bocklisch C, Bocklisch C, Pascoli V, Wong JC, House DR, Yvon C, de Roo M, Tan KR, Lüscher C. Cocaine disinhibits dopamine neurons by potentiation of GABA transmission in the ventral tegmental area. Science. 2013, 341:1521-5 [https://www.ncbi.nlm.nih.gov/pubmed/?term=Cocaine+disinhibits+dopamine+neurons+by+potentiation+of+GABA+transmission+in+the+ventral+tegmental+area DOI: 10.1126/science.1237059]

Pascoli V, Turiault M & Lüscher C. Reversing cocaine-evoked synaptic plasticity to reset drug-induced adaptive behavior. Nature, 2011, 481:71-5.[https://www.ncbi.nlm.nih.gov/pubmed/?term=Pascoli+V%2C+Turiault+M+%26+L%C3%BCscher DOI:10.1038/nature10709]

Tan KR, Brown MT, Labouebe G, Yvon C, Creton C, Fritschy JM, Rudolph U & Lüscher C. Neural bases for addictive properties of benzodiazepines. Nature, 2010, 463:769-74 [https://www.ncbi.nlm.nih.gov/pubmed/?term=Neural+bases+for+addictive+properties+of+benzodiazepines DOI:10.1038/nature08758]

References

External links

• {{cite web|url=https://www.semanticscholar.org/search?q=%22Christian+L%C3%BCscher%22&sort=relevance|title="Christian Lüscher" - Semantic Scholar|website=Semanticscholar.org|accessdate=15 December 2018}}
• {{cite web|url=https://www.ncbi.nlm.nih.gov/pubmed/?term=luscher+c|title=luscher c - PubMed|website=Ncbi.nlm.nih.gov|accessdate=15 December 2018}}

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