词条 | Cismadinone |
释义 |
| Verifiedfields = | Watchedfields = | verifiedrevid = | IUPAC_name = (1S,2R,8S,10R,11S,14R,15S)-14-acetyl-8-chloro-14-hydroxy-2,15-dimethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadeca-3,6-dien-5-one | image = Cismadinone.svg | width = | tradename = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = | CAS_number = 54063-31-9 | CAS_supplemental = | ATC_prefix = | ATC_suffix = | PubChem = 193990 | DrugBank_Ref = | DrugBank = | ChemSpiderID_Ref = | ChemSpiderID = 168332 | UNII = O00XM1O6TV | C=21 | H=27 | Cl=1 | O=3 | molecular_weight = 362.89028 g/mol | smiles = CC(=O)C1(CCC2C1(CCC3C2CC(C4=CC(=O)C=CC34C)Cl)C)O | StdInChI_Ref = | StdInChI = 1S/C21H27ClO3/c1-12(23)21(25)9-6-16-14-11-18(22)17-10-13(24)4-7-19(17,2)15(14)5-8-20(16,21)3/h4,7,10,14-16,18,25H,5-6,8-9,11H2,1-3H3/t14-,15+,16+,18+,19-,20+,21+/m1/s1 | StdInChIKey_Ref = | StdInChIKey = RNSISAJHBSCDGC-SCUQKFFVSA-N | synonyms = 6α-Chloro-1,2-didehydro-17α-hydroxyprogesterone }}Cismadinone (INN), also known as 6α-chloro-17α-hydroxypregna-1,4-diene-3,20-dione or 6α-chloro-δ1-dehydro-17α-hydroxyprogesterone, is a steroidal progestin closely related to the 17α-hydroxyprogesterone derivatives that was never marketed.[1][2] An acetylated form, cismadinone acetate, also exists, but similarly to cismadinone, was never marketed.[1] References1. ^1 {{cite book|author=J. Elks|title=The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies|url=https://books.google.com/books?id=0vXTBwAAQBAJ&pg=RA1-PA73|date=14 November 2014|publisher=Springer|isbn=978-1-4757-2085-3|page=284}} {{Progesterone receptor modulators}}{{genito-urinary-drug-stub}}{{steroid-stub}}2. ^{{citation | author = World Health Organization | title = The use of stems in the selection of International Nonproprietary Names (INN) for pharmaceutical substances | year = 2013 | page = 104 | url = http://apps.who.int/medicinedocs/collect/medicinedocs/pdf/s4895e/s4895e.pdf}} 4 : Organochlorides|Pregnanes|Progestogens|Abandoned drugs |
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