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Clouse is a surname. Notable people with the surname include: - Mark Clouse (born 1968), American businessman
- Michael J. Clouse, American record producer and songwriter
- Robert Clouse (1928–1997), American film director and producer
- Robert Clouse (professor) (1931-2016), American religious scholar
- Steve Clouse (born 1956), American politician
- Wynne F. Clouse (1883–1944), American politician
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