| 词条 | Combinatorial ablation and immunotherapy |
| 释义 |
| name = Combinatorial ablation and immunotherapy | synonym = | image = | caption = | alt = | pronounce = | specialty = oncology | synonyms = | ICD10 = | ICD9 = | ICD9unlinked = | CPT = | MeshID = | LOINC = | other_codes = | MedlinePlus = | eMedicine = }} Combinatorial ablation and immunotherapy is an oncological treatment that combines various tumor-ablation techniques with immunotherapy treatment.[1][2][3][4] Combining ablation therapy of tumors with immunotherapy enhances the immunostimulating response and has synergistic effects for curative metastatic cancer treatment.[2][3] Various ablative techniques are utilized including cryoablation, radiofrequency ablation, laser ablation, photodynamic ablation, stereotactic radiation therapy, hyperthermia therapy, HIFU.[5][6][7][8][9][10] Thus, combinatorial ablation of tumors and immunotherapy is a way of achieving autologous, in-vivo tumor lysate vaccine and treat metastatic disease. Mechanism of actionTake magnetic hyperthermia for example. By applying magnetic nanoparticle-mediated hyperthermia with a threshold of 43 °C in order not to damage surrounding normal tissues, a significant amount of heat-shock proteins (HSP) is expressed within and around the tumor tissues, inducing tumor-specific immune responses. In vivo experiments have indicated that magnetic nanoparticle-mediated hyperthermia can induce the regression of not only a local tumor tissue exposed to heat, but also distant metastatic tumors unexposed to heat. Partially or entirely ablating primary or secondary metastatic tumors induces necrosis of tumor cells, resulting in the release of antigens and presentation of antigens to the immune system. The released tumor antigens help activate anti-tumor T cells, which can destroy remaining malignant cells in local and distant tumors. Combining immunotherapy (ie: checkpoint inhibitors, CAR-T cell therapy) and vaccine adjuvants (ie: interferon, saponin) with ablation synergizes the immune reaction, and can treat metastatic disease with curative intent.[3][11][12][13][14][15] Ablation therapiesVarious local ablation therapies exist to induce necrosis of tumor cells and release tumor antigens for an immunological response, this is combined with immunotherapy:
See also
References1. ^{{Cite journal | author = Dupuy|display-authors=et al | title = Thermal ablation of tumours: biological mechanisms and advances in therapy| journal = Nature Reviews Cancer| volume = 14| issue = 3| pages = 199–208| year = 2014| doi = 10.1038/nrc3672| pmid = 24561446| url=http://www.nature.com/nrc/journal/v14/n3/abs/nrc3672.html}} 2. ^1 {{Cite journal | title = Thermal Ablative Therapies and Immune Checkpoint Modulation: Can Locoregional Approaches Effect a Systemic Response?| year = 2015| url=https://www.hindawi.com/journals/grp/2016/9251375/}} 3. ^1 2 {{Cite web | title = Immunotherapy could transform systemic power of locoregional IO treatments| year = 2016| url=https://interventionalnews.com/immunotherapy-could-transform-systemic-power-of-locoregional-io-treatments/}} 4. ^{{Cite book | title = Cancer Immunology and Immunotherapy| year = 2016| url=https://books.google.com/books?id=XSM545kh36oC&pg=PA218/|page=218| isbn = 9783642141362| author1 = Dranoff| first1 = Glenn}} 5. ^{{Cite web | author = Prof. Yona Keisari | title = Development of Cancer Treatments Integrating Radiotherapy or Electrochemical Ablation and Immunotherapy | url=https://en-med.tau.ac.il/research_ablation}} 6. ^{{Cite journal | year= 2003 | title = Tumor regression by combined immunotherapy and hyperthermia using magnetic nanoparticles in an experimental subcutaneous murine melanoma | journal = Cancer Science | volume = 94 | issue = 3 | pages = 308–13 | pmid = 12824927 | author1 = Ito | first1 = A | last2 = Tanaka | first2 = K | last3 = Kondo | first3 = K | last4 = Shinkai | first4 = M | last5 = Honda | first5 = H | last6 = Matsumoto | first6 = K | last7 = Saida | first7 = T | last8 = Kobayashi | first8 = T | doi = 10.1111/j.1349-7006.2003.tb01438.x }} 7. ^{{Cite journal | author =Xiaoming Yang | year = 2016 | title = Radiofrequency hyperthermia promotes the therapeutic effects on chemotherapeutic-resistant breast cancer when combined with heat shock protein promoter-controlled HSV-TK gene therapy: Toward imaging-guided interventional gene therapy | journal = Oncotarget | volume = 7 | issue = 40 | pages = 65042–65051 | doi = 10.18632/oncotarget.11346 | pmid = 27542255 | pmc = 5323137 }} 8. ^{{Cite journal | year= 2000 | title = Eradication of breast cancer xenografts by hyperthermic suicide gene therapy under the control of the heat shock protein promoter | journal = Human Gene Therapy | volume = 11 | issue = 18 | pages = 2453–63 | pmid = 11119417 | author1 = Braiden | first1 = V | last2 = Ohtsuru | first2 = A | last3 = Kawashita | first3 = Y | last4 = Miki | first4 = F | last5 = Sawada | first5 = T | last6 = Ito | first6 = M | last7 = Cao | first7 = Y | last8 = Kaneda | first8 = Y | last9 = Koji | first9 = T | last10 = Yamashita | first10 = S | doi = 10.1089/10430340050207948 }} 9. ^{{Cite book | year= 2016 | title = Hyperthermic Oncology from Bench to Bedside | pages = 319 | doi = 10.1007/978-981-10-0719-4_30 | chapter = Combination by Hyperthermia and Immunotherapy: DC Therapy and Hyperthermia | last1 = Takeda | first1 = Tsutomu | last2 = Takeda | first2 = Takashi | isbn = 978-981-10-0717-0 }} 10. ^{{Cite journal | journal=Austin Oncol Case Rep |year= 2017 | title = A New Strategy of Cancer Immunotherapy Combining Hyperthermia/Oncolytic Virus Pretreatment with Specific Autologous Anti-Tumor Vaccination | url=http://www.iozk.de/aktuelles/iozk_austin_oncology_case_reports_2017.pdf}} 11. ^{{cite journal | year = 2015 |title = Cryo-thermal therapy elicits potent anti-tumor immunity.| url =http://www.nature.com/articles/srep27136}} 12. ^Cryosurgery initiates inflammation and leaves tumor-specific antigens intact, which may induce an anti-tumor immune response.{{cite journal | year = 2005 |title = Immunologic response to cryoablation of breast cancer | author = Sabel | pmc=4115762 | pmid=25083502 | doi=10.3978/j.issn.2227-684X.2014.03.04 | volume=3 |issue = 2 | journal=Gland Surg | pages=88–93}} 13. ^{{cite journal | year = 2005 |title = Combined Dendritic Cell Cryotherapy of Tumor Induces Systemic Antimetastatic Immunity.| url =http://clincancerres.aacrjournals.org/content/11/13/4955}} 14. ^{{cite journal | year = 2016 |title = Thermal Ablative Therapies and Immune Checkpoint Modulation: Can Locoregional Approaches Effect a Systemic Response| journal = Gastroenterol Res Pract | doi=10.1155/2016/9251375 |pmid = 27051417|pmc = 4802022| volume=2016 | pages=1–11|last1 = Mehta|first1 = Amol|last2 = Oklu|first2 = Rahmi|last3 = Sheth|first3 = Rahul A.}} 15. ^{{Cite journal | year= 2012 | title = Nanoparticle-mediated hyperthermia in cancer therapy. | journal = Therapeutic Delivery | volume = 2 | issue = 8 | pages = 1001–1014 | pmc = 3323111 | last1 = Chatterjee | first1 = D. K. | last2 = Diagaradjane | first2 = P. | last3 = Krishnan | first3 = S. | pmid = 22506095 | doi = 10.4155/tde.11.72 }} 2 : Oncology|Immunotherapy |
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