| 词条 | Cortifen |
| 释义 |
| Verifiedfields = | Watchedfields = | verifiedrevid = | IUPAC_name = [2-[(8R,9S,10R,13S,14S,17R)-17-hydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] 2-[4-[bis(2-chloroethyl)amino]phenyl]acetate | image = Cortifen.svg | width = 250px | tradename = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = | class = Cytostatic antineoplastic agent; Corticosteroid; Glucocorticoid | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = | CAS_number = | CAS_supplemental = | ATC_prefix = | ATC_suffix = | ATC_supplemental = | PubChem = 9873581 | IUPHAR_ligand = | DrugBank_Ref = | DrugBank = | ChemSpiderID_Ref = | ChemSpiderID = 8049270 | UNII = | KEGG = | ChEBI = | ChEMBL = | synonyms = Cortiphen; Kortifen; Fencoron; 11-Deoxycortisol 21-(4-(bis(2-chloroethyl)amino)phenyl)acetate; 11-Desoxy-17α-hydroxy-21-[n-di-2(chlorethyl)aminophenyl acetate]corticosterone | C=33 | H=43 | Cl=2 | N=1 | O=5 | molecular_weight = 604.609 g/mol | SMILES = C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2CC[C@]4([C@H]3CC[C@@]4(C(=O)COC(=O)CC5=CC=C(C=C5)N(CCCl)CCCl)O)C | StdInChI_Ref = | StdInChI = 1S/C33H43Cl2NO5/c1-31-12-9-25(37)20-23(31)5-8-26-27(31)10-13-32(2)28(26)11-14-33(32,40)29(38)21-41-30(39)19-22-3-6-24(7-4-22)36(17-15-34)18-16-35/h3-4,6-7,20,26-28,40H,5,8-19,21H2,1-2H3/t26-,27+,28+,31+,32+,33+/m1/s1 | StdInChIKey_Ref = | StdInChIKey = PHIDEGNDCDIEQX-LNPWAVATSA-N }}Cortifen, also known as cortiphen or kortifen, as well as fencoron, is a synthetic glucocorticoid corticosteroid and cytostatic antineoplastic agent which was developed in Russia for potential treatment of tumors.[1][2][3] It is a hydrophobic chlorphenacyl nitrogen mustard ester of 11-deoxycortisol (cortodoxone).[1][2][3][4] See also
References1. ^1 {{cite journal | vauthors = Lagova ND, Kiselev VI, Kurdiumova KN, Sof'ina ZP, Shkodinskaia EN | title = [Experimental study of the antitumor properties and mechanism of action of kortifen] | language = Russian | journal = Vopr Onkol | volume = 35 | issue = 4 | pages = 450–6 | year = 1989 | pmid = 2728387 | doi = | url = }} {{Glucocorticoid receptor modulators}}{{Mineralocorticoid receptor modulators}}{{Steroid-stub}}{{Antineoplastic-drug-stub}}2. ^1 {{cite journal|last1=Oborotov|first1=A. V.|last2=Smirnova|first2=Z. S.|last3=Klochkova|first3=T. I.|last4=Arzamastsev|first4=A. P.|title=Biopharmaceutical investigation of a new medicinal form of the antitumor drug cortifen|journal=Pharmaceutical Chemistry Journal|volume=33|issue=10|year=1999|pages=540–542|issn=0091-150X|doi=10.1007/BF02508377}} 3. ^1 {{cite journal|last1=Smirnova|first1=Z. S.|last2=Rodionova|first2=Yu. V.|last3=Khalanskii|first3=A. S.|last4=Gershtein|first4=E. S.|last5=Gerasimova|first5=G. K.|title=Dependence of antitumor effect of hormonal cytostatic cortifen on expression of glucocorticoid receptors in brain tumor cells|journal=Bulletin of Experimental Biology and Medicine|volume=127|issue=3|year=1999|pages=299–300|issn=0007-4888|doi=10.1007/BF02433363}} 4. ^{{cite journal | vauthors = Oborotova NA, Smirnova ZS, Polozkova ZS, ((Baryshnikov AIu)) | title = [Pharmacological aspects in the development of liposomal medicinal preparations for the internal injection of hydrophobic cytostatics] | language = Russian | journal = Vestn. Akad. Med. Nauk SSSR | volume = | issue = 1 | pages = 42–5 | year = 2002 | pmid = 11882971 | doi = | url = }} 12 : Acetate esters|Alcohols|Amines|Corticosteroid esters|Glucocorticoids|Ketones|Mineralocorticoids|Nitrogen mustards|Organochlorides|Prodrugs|Russian drugs|Chloroethyl compounds |
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