| 词条 | CPC Scientific |
| 释义 |
| name = CPC Scientific Inc. | logo = | type = Private Company | foundation = 2001 | location = Sunnyvale, California | key_people = Shawn Lee (Chairman and Founder), Irvine Skeoch (COO), Xiaohe Tong (Chief Technical Officer) | industry = Chemicals, biotechnology | products = Biopharmaceuticals, research peptides, custom peptides active pharmaceutical ingredients (API), and generics | homepage = www.cpcscientific.com }} CPC Scientific is a biotechnology company that manufactures peptides. The company provides a number of products and services to academic researchers and pharmaceutical industries, including research- and GMP-grade custom peptides. HistoryHeadquartered in Sunnyvale, California, CPC Scientific was founded in 2001 by Dr. Shawn Lee, Ph.D. Product lines initially included research-grade custom peptides, catalog peptides, and Fmoc-protected amino acids.[1] In 2006, CPC Scientific opened a GMP (Good Manufacturing Practice) facility in Hangzhou, China and began producing GMP-grade peptides for use in clinical applications. By 2011, the GMP facility was inspected by the U.S. Food and Drug Administration (FDA) and the company began supplying pharmaceutical-grade peptides to companies in the United States. On March 17, 2016, CPC Scientific passed a 4th U.S. FDA inspection.[2] ManufacturingCPC Scientific manufactures most of their products by way of solid-phase peptide synthesis, a process originally described by Robert Bruce Merrifield in 1963. Solid-phase synthesis routes enable manufacturing of relatively long peptide sequences by avoiding isolation and purification of synthetic intermediates. This iterative process allows for the preparation of more complex peptides for use as active pharmaceutical ingredients (APIs), novel drug therapeutics, and general research applications. CPC Scientific has published some research articles that describe peptide synthesis methodologies,[3][4] including a technique called hydrocarbon stapling.[5][6] Stapled peptides contain a synthetic modification that involves olefin metathesis to stabilize alpha-helix and beta-sheet secondary structures. Products manufactured by CPC Scientific have also been cited in scientific journals.[7][8][9][10][11] References1. ^{{cite web|title=CPC Scientific Inc. - Profile|url=http://www.cpcscientific.com/company-profile/}} 2. ^{{cite web|title=CPC Scientific Inc. - 4th US FDA inspection|url=http://www.prnewswire.com/news-releases/cpc-scientific-successfully-passes-4th-us-fda-inspection-300246899.html/}} 3. ^{{cite journal|title= Synthesis, antiviral activity and resistance of a novel small molecule HIV-1 entry inhibitor. |url=http://www.sciencedirect.com/science/article/pii/S0968089615301310 | doi=10.1016/j.bmc.2015.11.006 |pmid=26602829 | volume=23|issue=24 |journal=Bioorganic & Medicinal Chemistry|pages=7618–7628|pmc=4684972|year=2015 |last1=Curreli |first1=F. |last2=Haque |first2=K. |last3=Xie |first3=L. |last4=Qiu |first4=Q. |last5=Xu |first5=J. |last6=Yong |first6=W. |last7=Tong |first7=X. |last8=Debnath |first8=A. K. }} 4. ^{{cite web|title= Capon, Daniel J., et al. "Flexible antibodies with nonprotein hinges." Proceedings of the Japan Academy, Series B 87.9 (2011): 603-616.|url= https://www.jstage.jst.go.jp/article/pjab/87/9/87_9_603/_article}} 5. ^{{cite journal|doi=10.1021/ja202946k | pmid=21612236 | volume=133 | issue=25 | title=Design and Structure of Stapled Peptides Binding to Estrogen Receptors | journal=Journal of the American Chemical Society | pages=9696–9699| year=2011 | last1=Phillips | first1=Chris | last2=Roberts | first2=Lee R. | last3=Schade | first3=Markus | last4=Bazin | first4=Richard | last5=Bent | first5=Andrew | last6=Davies | first6=Nichola L. | last7=Moore | first7=Rob | last8=Pannifer | first8=Andrew D. | last9=Pickford | first9=Andrew R. | last10=Prior | first10=Stephen H. | last11=Read | first11=Christopher M. | last12=Scott | first12=Andrew | last13=Brown | first13=David G. | last14=Xu | first14=Bin | last15=Irving | first15=Stephen L. }} 6. ^{{cite journal|doi=10.1186/1742-4690-10-136 | pmid=24237936 | pmc=3842668 | volume=10 | title=Dual-acting stapled peptides target both HIV-1 entry and assembly | journal=Retrovirology | page=136| year=2013 | last1=Zhang | first1=Hongtao | last2=Curreli | first2=Francesca | last3=Waheed | first3=Abdul A. | last4=Mercredi | first4=Peter Y. | last5=Mehta | first5=Mansi | last6=Bhargava | first6=Pallavi | last7=Scacalossi | first7=Daniel | last8=Tong | first8=Xiaohe | last9=Lee | first9=Shawn | last10=Cooper | first10=Alan | last11=Summers | first11=Michael F. | last12=Freed | first12=Eric O. | last13=Debnath | first13=Asim K. }} 7. ^{{cite web|title= Sharma, Rajesh K., et al. "Costimulation as a platform for the development of vaccines: a peptide-based vaccine containing a novel form of 4-1BB ligand eradicates established tumors." Cancer research 69.10 (2009): 4319-4326.|url=http://cancerres.aacrjournals.org/content/69/10/4319.long}} 8. ^{{cite journal|title=Mentinova, Marija, and Scott A. McLuckey. "Covalent modification of gaseous peptide ions with N-hydroxysuccinimide ester reagent ions." Journal of the American Chemical Society 132.51 (2010): 18248-18257.|journal=Journal of the American Chemical Society|volume=132|issue=51|pages=18248–18257|doi=10.1021/ja107286p|pmid=21128662|pmc=3010255|year=2010|last1=Mentinova|first1=Marija|last2=McLuckey|first2=Scott A.}} 9. ^{{cite journal|title= Sun, Tzu-Lin, et al. "Membrane permeability of hydrocarbon-cross-linked peptides." Biophysical Journal 104.9 (2013): 1923-1932.|url=http://www.cell.com/biophysj/fulltext/S0006-3495(13)00378-0 | doi=10.1016/j.bpj.2013.03.039 |pmid=23663835 | volume=104|issue=9 |journal=Biophysical Journal|pages=1923–1932|year=2013 |last1=Sun |first1=Tzu-Lin |last2=Sun |first2=Yen |last3=Lee |first3=Chang-Chun |last4=Huang |first4=Huey W. }} 10. ^{{cite journal|title=Vanderpool, Darin, et al. "Characterization of the CHK1 allosteric inhibitor binding site." Biochemistry 48.41 (2009): 9823-9830.|journal=Biochemistry|volume=48|issue=41|pages=9823–9830|doi=10.1021/bi900258v|pmid=19743875|year=2009|last1=Vanderpool|first1=Darin|last2=Johnson|first2=Ted O.|last3=Ping|first3=Chen|last4=Bergqvist|first4=Simon|last5=Alton|first5=Gordon|last6=Phonephaly|first6=Soneprasith|last7=Rui|first7=Eugene|last8=Luo|first8=Chun|last9=Deng|first9=Ya-Li|last10=Grant|first10=Stephan|last11=Quenzer|first11=Terri|last12=Margosiak|first12=Steve|last13=Register|first13=James|last14=Brown|first14=Ed|last15=Ermolieff|first15=Jacques}} 11. ^{{cite web|title= Ardiani, Andressa, et al. "Vaccine-mediated immunotherapy directed against a transcription factor driving the metastatic process." Cancer research 74.7 (2014): 1945-1957.|url=http://cancerres.aacrjournals.org/content/74/7/1945.full}} External links
6 : Biotechnology companies of the United States|Biotechnology companies established in 2001|Privately held companies based in California|Companies based in Sunnyvale, California|Technology companies based in California|2001 establishments in California |
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