| 释义 |
- Function
- References
- Further reading
{{Infobox_gene}}CAMP responsive element binding protein 3 like 1 is a responsive element binding protein that in humans is encoded by the CREB3L1 gene.[1] Function The protein encoded by this gene is normally found in the membrane of the endoplasmic reticulum (ER). However, upon stress to the ER, the encoded protein is cleaved, and the released cytoplasmic transcription factor domain translocates to the nucleus. There it activates the transcription of target genes by binding to box-B elements. [provided by RefSeq, Jun 2013]. References 1. ^{{cite web | title = Entrez Gene: CAMP responsive element binding protein 3 like 1 | url = https://www.ncbi.nlm.nih.gov/gene/90993 }}
Further reading {{refbegin | 2}}- {{cite journal | vauthors = Omori Y, Imai J, Suzuki Y, Watanabe S, Tanigami A, Sugano S | title = OASIS is a transcriptional activator of CREB/ATF family with a transmembrane domain | journal = Biochemical and Biophysical Research Communications | volume = 293 | issue = 1 | pages = 470–7 | date = April 2002 | pmid = 12054625 | doi = 10.1016/S0006-291X(02)00253-X }}
- {{cite journal | vauthors = Guillou L, Benhattar J, Gengler C, Gallagher G, Ranchère-Vince D, Collin F, Terrier P, Terrier-Lacombe MJ, Leroux A, Marquès B, Aubain Somerhausen N, Keslair F, Pedeutour F, Coindre JM | title = Translocation-positive low-grade fibromyxoid sarcoma: clinicopathologic and molecular analysis of a series expanding the morphologic spectrum and suggesting potential relationship to sclerosing epithelioid fibrosarcoma: a study from the French Sarcoma Group | journal = The American Journal of Surgical Pathology | volume = 31 | issue = 9 | pages = 1387–402 | date = September 2007 | pmid = 17721195 | doi = 10.1097/PAS.0b013e3180321959 }}
- {{cite journal | vauthors = Fox RM, Hanlon CD, Andrew DJ | title = The CrebA/Creb3-like transcription factors are major and direct regulators of secretory capacity | journal = The Journal of Cell Biology | volume = 191 | issue = 3 | pages = 479–92 | date = November 2010 | pmid = 21041443 | pmc = 3003312 | doi = 10.1083/jcb.201004062 }}
- {{cite journal | vauthors = Möller E, Hornick JL, Magnusson L, Veerla S, Domanski HA, Mertens F | title = FUS-CREB3L2/L1-positive sarcomas show a specific gene expression profile with upregulation of CD24 and FOXL1 | journal = Clinical Cancer Research | volume = 17 | issue = 9 | pages = 2646–56 | date = May 2011 | pmid = 21536545 | doi = 10.1158/1078-0432.CCR-11-0145 }}
- {{cite journal | vauthors = Denard B, Seemann J, Chen Q, Gay A, Huang H, Chen Y, Ye J | title = The membrane-bound transcription factor CREB3L1 is activated in response to virus infection to inhibit proliferation of virus-infected cells | journal = Cell Host & Microbe | volume = 10 | issue = 1 | pages = 65–74 | date = July 2011 | pmid = 21767813 | pmc = 3139916 | doi = 10.1016/j.chom.2011.06.006 }}
- {{cite journal | vauthors = Denard B, Seemann J, Chen Q, Gay A, Huang H, Chen Y, Ye J | title = The membrane-bound transcription factor CREB3L1 is activated in response to virus infection to inhibit proliferation of virus-infected cells | journal = Cell Host & Microbe | volume = 10 | issue = 1 | pages = 65–74 | date = July 2011 | pmid = 21767813 | pmc = 3139916 | doi = 10.1016/j.chom.2011.06.006 }}
- {{cite journal | vauthors = Debelenko LV, McGregor LM, Shivakumar BR, Dorfman HD, Raimondi SC | title = A novel EWSR1-CREB3L1 fusion transcript in a case of small cell osteosarcoma | journal = Genes, Chromosomes & Cancer | volume = 50 | issue = 12 | pages = 1054–62 | date = December 2011 | pmid = 21987447 | doi = 10.1002/gcc.20923 }}
- {{cite journal | vauthors = Kondo S, Hino SI, Saito A, Kanemoto S, Kawasaki N, Asada R, Izumi S, Iwamoto H, Oki M, Miyagi H, Kaneko M, Nomura Y, Urano F, Imaizumi K | title = Activation of OASIS family, ER stress transducers, is dependent on its stabilization | journal = Cell Death and Differentiation | volume = 19 | issue = 12 | pages = 1939–49 | date = December 2012 | pmid = 22705851 | pmc = 3504707 | doi = 10.1038/cdd.2012.77 }}
- {{cite journal | vauthors = Denard B, Lee C, Ye J | title = Doxorubicin blocks proliferation of cancer cells through proteolytic activation of CREB3L1 | journal = eLife | volume = 1 | issue = | pages = e00090 | date = December 2012 | pmid = 23256041 | pmc = 3524649 | doi = 10.7554/eLife.00090 }}
{{refend}}{{NLM content}}{{gene-11-stub}} |