| 词条 | David Tuveson |
| 释义 |
| honorific_prefix = | name = David Tuveson | honorific_suffix = | native_name = | native_name_lang = | image = | image_size = | alt = | caption = | birth_date = {{birth date and age|1966|01|01}} | birth_place = | death_date = | death_place = | death_cause = | resting_place = | resting_place_coordinates = | other_names = | residence = | citizenship = | nationality = American | fields = Cancer biology | workplaces = Cold Spring Harbor Laboratory | patrons = | education = Massachusetts Institute of Technology | alma_mater = | thesis_title = | thesis_url = | thesis_year = | doctoral_advisor = Douglas Fearon | academic_advisors = | doctoral_students = | notable_students = | known_for = Developing mouse and organoid models of pancreatic cancer | influences = | influenced = | awards = Rita Allen Foundation Scholar Award | author_abbrev_bot = | author_abbrev_zoo = | spouse = | partner = | children = | signature = | signature_alt = | website = | footnotes = }}David Arthur Tuveson (born January 1, 1966) is an American cancer biologist and is currently a professor as well as The Cancer Center Director and The Director of the Cancer Therapeutics Initiative at Cold Spring Harbor Laboratory. Dr. Tuveson is also the Chief Scientist for the Lustgarten Foundation for Pancreatic Cancer Research.[1] He is known for developing some of the first mouse models of pancreatic cancer and more recently, for his work developing pancreatic cancer organoids.[2][3] Education and TrainingDavid Tuveson received a B.S. in chemistry from the Massachusetts Institute of Technology in 1987. He received an M.D.-Ph.D. from the Johns Hopkins School of Medicine in 1994, where his Ph.D. adviser was Douglas Fearon. He completed a residency at Brigham and Women's Hospital from 1994-1997. From 1997-2000, he pursued a Fellowship in Hematology and Oncology at the Dana–Farber Cancer Institute. During this time, he also performed postdoctoral research in mouse models of lung cancer in the laboratory of Tyler Jacks at the Massachusetts Institute of Technology.[4] CareerFollowing completion of his fellowship training, Tuveson started his own laboratory at the University of Pennsylvania, where he was Assistant Professor of Medicine from 2002-2006.[5] In 2006, he moved to the Cambridge Research Institute, where he was a Senior Group Leader and a Professor of Pancreatic Cancer Medicine. In 2012, he took a position as a group leader and The Deputy Director of the Cancer Center at Cold Spring Harbor Laboratory.[5] ResearchDuring his postdoctoral training in the Jacks Laboratory, Tuveson learned how to engineer mouse models to study human cancer.[5] During this time, he also studied gastrointestinal stromal tumors (GISTs), and worked with Dr. George Demetri to develop imatinib as a treatment for GIST.[6] When he started his own laboratory at the University of Pennsylvania, Tuveson developed some of the first genetically engineered mouse models to aid in the study of pancreatic cancer.[7][8][9] Using these mice, Tuveson has made several important discoveries in the biology of pancreatic cancer, including the work that contributed to the idea that the stromal cells of pancreatic tumors act as a barrier for therapies.[10] He later partnered with Hans Clevers to develop pancreatic cancer organoids – tumor cells taken from a human patient and cultured in the laboratory as three-dimensional spheres.[11] He is working with the National Cancer Institute to develop organoids for use in personalized medicine approaches to treating cancer.[12] Honors and awardsDavid Tuveson was given an AACR-PanCAN Career Development Award in Pancreatic Cancer research in 2003. He was also the recipient of an M.L. Smith Award in 2003 and a Rita Allen Foundation Scholar Award in 2004. He has also received a Distinguished Scholar Award from the Lustgarten Foundation.[13] Major publicationsTuveson has more than 100 publications, and has been cited more than 15,000 times. Some of his most important publications are:
References1. ^{{cite web |title = Lustgarten Foundation Leadership |url =https://www.lustgarten.org/leadership }} 2. ^{{cite web| title =Mice Model a Silent Killer| work =The Scientist| url =http://www.the-scientist.com/?articles.view/articleNo/15525/title/Mice-Model-a-Silent-Killer/ }} 3. ^{{cite news |url=http://www.medicalnewstoday.com/articles/287539.php |title=Ability to culture 'organoids' set to transform pancreatic cancer research |date=2015-01-04 |work=Medical News Today }} 4. ^{{cite web| title =Stand Up to Cancer Scientific Advisory Committee Biographies| work =Stand Up to Cancer| url =https://www.standup2cancer.org/scientific_advisors/biographies }} 5. ^1 2 {{cite web| title =SU2C-CRUK-Lustgarten Foundation Joint Scientific Advisory Committee: David Tuveson| work =AACR| url =http://www.aacr.org/Funding/Pages/SU2C-CRUK-Lustgarten-Foundation-Joint-Scientific-Advisory-Committee-detail.aspx?ItemID=4#.Vo8K1lLESNp}} 6. ^{{cite journal |last=Demetri |first=George M. |last2=von Mehren |first2=Margaret |last3=Blanke |first3=Charles D. |last4=Van den Abbeele |first4=Annick D. |last5=Eisenberg |first5=Burton |last6=Roberts |first6=Peter J. |last7=Heinrich |first7=Michael C. |last8=Tuveson |first8=David A. |last9=Singer |first9=Samuel |last10=Janicek |first10=Milos |last11=Fletcher |first11=Jonathan A. |last12=Silverman |first12=Stuart G. |last13=Silberman |first13=Sandra L. |last14=Capdeville |first14=Renaud |last15=Kiese |first15=Beate |last16=Peng |first16=Bin |last17=Dimitrijevic |first17=Sasa |last18=Druker |first18=Brian J. |last19=Corless |first19=Christopher |last20=Fletcher |first20=Christopher D.M. |last21=Joensuu |first21=Heikki |date=2002 |title=Efficacy and Safety of Imatinib Mesylate in Advanced Gastrointestinal Stromal Tumors |journal=New England Journal of Medicine |volume=347 |issue= 7|pages=472–480 |doi=10.1056/NEJMoa020461 |pmid=12181401 }} 7. ^{{cite web| title =A Story of Discovery: KRAS Mouse Model Advances Pancreatic Cancer Research | work =NIH| url =http://www.cancer.gov/research/progress/discovery/kras-model}} 8. ^{{cite journal |vauthors=Hingorani SR, Petricoin EF, Maitra A, Rajapakse V, King C, Jacobetz MA, Ross S, Conrads TP, Veenstra TD, Hitt BA, Kawaguchi Y, Johann D, Liotta LA, Crawford HC, Putt ME, Jacks T, Wright CV, Hruban RH, Lowy AM, Tuveson DA |date=2003 |title=Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse |url=http://www.sciencedirect.com/science/article/pii/S153561080300309X |journal=Cancer Cell |volume=4 |issue=6 |pages=437–450 |doi=10.1016/S1535-6108(03)00309-X |pmid=14706336}} 9. ^{{cite journal |vauthors=Hingorani SR, Wang L, Multani AS, Combs C, Deramaudt TB, Hruban RH, Rustgi AK, Chang S, Tuveson DA |date=2005 |title=Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice |url=http://www.sciencedirect.com/science/article/pii/S1535610805001285 |journal=Cancer Cell |volume=7 |issue=5 |pages=469–483 |doi=10.1016/j.ccr.2005.04.023 |pmid=15894267}} 10. ^{{cite journal |vauthors=Olive KP, Jacobetz MA, Davidson CJ, Gopinathan A, McIntyre D, Honess D, Madhu B, Goldgraben MA, Caldwell ME, Allard D, Frese KK, Denicola G, Feig C, Combs C, Winter SP, Ireland-Zecchini H, Reichelt S, Howat WJ, Chang A, Dhara M, Wang L, Rückert F, Grützmann R, Pilarsky C, Izeradjene K, Hingorani SR, Huang P, Davies SE, Plunkett W, Egorin M, Hruban RH, Whitebread N, McGovern K, Adams J, Iacobuzio-Donahue C, Griffiths J, Tuveson DA |date=2009 |title=Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer |journal=Science |volume=324 |issue=5933 |pages=1457–1461 |doi=10.1126/science.1171362 |pmid=19460966 |pmc=2998180}} 11. ^{{cite journal |vauthors=Boj SF, Hwang CI, Baker LA, Chio II, Engle DD, Corbo V, Jager M, Ponz-Sarvise M, Tiriac H, Spector MS, Gracanin A, Oni T, Yu KH, van Boxtel R, Huch M, Rivera KD, Wilson JP, Feigin ME, Öhlund D, Handly-Santana A, Ardito-Abraham CM, Ludwig M, Elyada E, Alagesan B, Biffi G, Yordanov GN, Delcuze B, Creighton B, Wright K, Park Y, Morsink FH, Molenaar IQ, Borel Rinkes IH, Cuppen E, Hao Y, Jin Y, Nijman IJ, Iacobuzio-Donahue C, Leach SD, Pappin DJ, Hammell M, Klimstra DS, Basturk O, Hruban RH, Offerhaus GJ, Vries RG, Clevers H, Tuveson DA |date=2015 |title=Organoid models of human and mouse ductal pancreatic cancer |url=http://www.sciencedirect.com/science/article/pii/S009286741401592X |journal=Cell |volume=160 |issue=1–2 |pages=324–338 |doi=10.1016/j.cell.2014.12.021 |pmid=25557080 |pmc=4334572}} 12. ^{{cite web| title =3D culture system for pancreatic cancer has potential to change therapeutic approaches | work =Cold Spring Harbor Laboratory| url =http://www.cshl.edu/news-and-features/3d-culture-system-for-pancreatic-cancer-has-potential-to-change-therapeutic-approaches.html}} 13. ^{{cite web| title =Distinguished Scholar Award Recipients | work =Lustgarten Foundation| url =http://www.lustgarten.org/Distinguished-Scholar-Recipients}} External links
5 : Massachusetts Institute of Technology alumni|Johns Hopkins School of Medicine alumni|1966 births|Living people|Place of birth missing (living people) |
| 随便看 |
|
开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。