| 词条 | DcuC family |
| 释义 |
The C4-dicarboxylate uptake C family or DcuC family (TC# 2.A.61) is a family of transmembrane ion transporters found in bacteria.[1] A representative list of proteins belonging to the DcuC family can be found in the Transporter Classification Database. An anaerobic C4-dicarboxylate transporter (DcuC) of E. coli (TC# 2.A.61.1.1) has 14 putative transmembrane regions, is induced only under anaerobic conditions, and is not repressed by glucose. DcuC may therefore function as a succinate efflux system during anaerobic glucose fermentation. However, when overexpressed, it can replace either DcuA or DcuB in catalysing fumarate-succinate exchange and fumarate uptake.[2][3] DcuC shows the same transport modes as DcuA and DcuB (exchange, uptake, and presumably efflux of C4-dicarboxylates).[4][5] The reactions probably catalyzed by the E. coli DcuC protein are:
See also
References1. ^{{Cite journal|last=Prakash|first=Shraddha|last2=Cooper|first2=Garret|last3=Singhi|first3=Soumya|last4=Saier|first4=Milton H.|date=2003-12-03|title=The ion transporter superfamily|journal=Biochimica et Biophysica Acta|volume=1618|issue=1|pages=79–92|issn=0006-3002|pmid=14643936|doi=10.1016/j.bbamem.2003.10.010}} {{Portal bar|Molecular and Cellular Biology|border=no}}{{InterPro content|IPR003606}}{{membrane-protein-stub}}2. ^{{cite journal|date=June 1994|title=Transport of C4-dicarboxylates by anaerobically grown Escherichia coli. Energetics and mechanism of exchange, uptake and efflux|url=|journal=Eur. J. Biochem.|volume=222|issue=2|pages=605–14|doi=10.1111/j.1432-1033.1994.tb18903.x|pmid=8020497|vauthors=Engel P, Kramer R, Unden G }} 3. ^{{cite journal|date=June 1999|title=Functioning of DcuC as the C4-dicarboxylate carrier during glucose fermentation by Escherichia coli|url=|journal=J. Bacteriol.|volume=181|issue=12|pages=3716–20|doi=|pmc=93849|pmid=10368146|vauthors=Zientz E, Janausch IG, Six S, Unden G }} 4. ^{{cite journal|date=December 1996|title=Identification of a third secondary carrier (DcuC) for anaerobic C4-dicarboxylate transport in Escherichia coli: roles of the three Dcu carriers in uptake and exchange|url=|journal=J. Bacteriol.|volume=178|issue=24|pages=7241–7|doi=10.1128/jb.178.24.7241-7247.1996 |pmc=178639|pmid=8955408|vauthors=Zientz E, Six S, Unden G }} 5. ^{{Cite web|url=http://www.tcdb.org/search/result.php?tc=2.A.61|title=2.A.61 The C4-dicarboxylate Uptake C (DcuC) Family|website=Transporter Classification Database|access-date=2016-03-04}} 2 : Protein families|Transmembrane transporters |
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