| 释义 |
- Function
- References
- Further reading
{{Infobox_gene}}Diacylglycerol O-acyltransferase 2 is a protein that in humans is encoded by the DGAT2 gene. [1]FunctionThis gene encodes one of two enzymes which catalyzes the final reaction in the synthesis of triglycerides in which diacylglycerol is covalently bound to long chain fatty acyl-CoAs. The encoded protein catalyzes this reaction at low concentrations of magnesium chloride while the other enzyme has high activity at high concentrations of magnesium chloride. Multiple transcript variants encoding different isoforms have been found for this gene. References 1. ^{{cite web| title = Entrez Gene: Diacylglycerol O-acyltransferase 2| url = https://www.ncbi.nlm.nih.gov/gene/84649| accessdate = 2017-07-18}}
Further reading {{refbegin | 2}}- {{cite journal |vauthors=Wakimoto K, Chiba H, Michibata H, Seishima M, Kawasaki S, Okubo K, Mitsui H, Torii H, Imai Y |title=A novel diacylglycerol acyltransferase (DGAT2) is decreased in human psoriatic skin and increased in diabetic mice |journal=Biochem. Biophys. Res. Commun. |volume=310 |issue=2 |pages=296–302 |year=2003 |pmid=14521909 |doi= 10.1016/j.bbrc.2003.09.015|url=}}
- {{cite journal |vauthors=Ganji SH, Tavintharan S, Zhu D, Xing Y, Kamanna VS, Kashyap ML |title=Niacin noncompetitively inhibits DGAT2 but not DGAT1 activity in HepG2 cells |journal=J. Lipid Res. |volume=45 |issue=10 |pages=1835–45 |year=2004 |pmid=15258194 |doi=10.1194/jlr.M300403-JLR200 |url=}}
- {{cite journal |vauthors=Friedel S, Reichwald K, Scherag A, Brumm H, Wermter AK, Fries HR, Koberwitz K, Wabitsch M, Meitinger T, Platzer M, Biebermann H, Hinney A, Hebebrand J |title=Mutation screen and association studies in the diacylglycerol O-acyltransferase homolog 2 gene (DGAT2), a positional candidate gene for early onset obesity on chromosome 11q13 |journal=BMC Genet. |volume=8 |issue= |pages=17 |year=2007 |pmid=17477860 |pmc=1871603 |doi=10.1186/1471-2156-8-17 |url=}}
- {{cite journal |vauthors=Friedel S, Reichwald K, Scherag A, Brumm H, Wermter AK, Fries HR, Koberwitz K, Wabitsch M, Meitinger T, Platzer M, Biebermann H, Hinney A, Hebebrand J |title=Mutation screen and association studies in the diacylglycerol O-acyltransferase homolog 2 gene (DGAT2), a positional candidate gene for early onset obesity on chromosome 11q13 |journal=BMC Genet. |volume=8 |issue= |pages=17 |year=2007 |pmid=17477860 |pmc=1871603 |doi=10.1186/1471-2156-8-17 |url=}}
- {{cite journal |vauthors=Payne VA, Au WS, Gray SL, Nora ED, Rahman SM, Sanders R, Hadaschik D, Friedman JE, O'rahilly S, Rochford JJ |title=Sequential regulation of diacylglycerol acyltransferase 2 expression by CAAT/enhancer-binding protein beta (C/EBPbeta) and C/EBPalpha during adipogenesis |journal=J. Biol. Chem. |volume=282 |issue=29 |pages=21005–14 |year=2007 |pmid=17504763 |pmc=2254492 |doi=10.1074/jbc.M702871200 |url=}}
- {{cite journal |vauthors=Levin MC, Monetti M, Watt MJ, Sajan MP, Stevens RD, Bain JR, Newgard CB, Farese RV, Farese RV |title=Increased lipid accumulation and insulin resistance in transgenic mice expressing DGAT2 in glycolytic (type II) muscle |journal=Am. J. Physiol. Endocrinol. Metab. |volume=293 |issue=6 |pages=E1772–81 |year=2007 |pmid=17940217 |doi=10.1152/ajpendo.00158.2007 |url=}}
- {{cite journal |vauthors=Yen CL, Stone SJ, Koliwad S, Harris C, Farese RV |title=Thematic review series: glycerolipids. DGAT enzymes and triacylglycerol biosynthesis |journal=J. Lipid Res. |volume=49 |issue=11 |pages=2283–301 |year=2008 |pmid=18757836 |pmc=3837458 |doi=10.1194/jlr.R800018-JLR200 |url=}}
- {{cite journal |vauthors=Kantartzis K, Machicao F, Machann J, Schick F, Fritsche A, Häring HU, Stefan N |title=The DGAT2 gene is a candidate for the dissociation between fatty liver and insulin resistance in humans |journal=Clin. Sci. |volume=116 |issue=6 |pages=531–7 |year=2009 |pmid=18980578 |doi=10.1042/CS20080306 |url=}}
- {{cite journal |vauthors=Stone SJ, Levin MC, Zhou P, Han J, Walther TC, Farese RV |title=The endoplasmic reticulum enzyme DGAT2 is found in mitochondria-associated membranes and has a mitochondrial targeting signal that promotes its association with mitochondria |journal=J. Biol. Chem. |volume=284 |issue=8 |pages=5352–61 |year=2009 |pmid=19049983 |pmc=2643492 |doi=10.1074/jbc.M805768200 |url=}}
{{refend}}{{NLM content}}{{gene-11-stub}} |