| 词条 | Diethylstilbestrol monobenzyl ether |
| 释义 |
| Verifiedfields = | Watchedfields = | verifiedrevid = | IUPAC_name = 4-[(E)-4-(4-phenylmethoxyphenyl)hex-3-en-3-yl]phenol | image = Diethylstilbestrol monobenzyl ether.svg | width = 250px | tradename = Monozol, Hypantin, Pituitrope | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = | class = Nonsteroidal estrogen; Estrogen ether | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = | CAS_number = 6202-26-2 | CAS_supplemental = | ATCvet = | ATC_prefix = | ATC_suffix = | ATC_supplemental = | PubChem = 3036244 | IUPHAR_ligand = | DrugBank_Ref = | DrugBank = | ChemSpiderID_Ref = | ChemSpiderID = 2300304 | UNII = | KEGG = | ChEBI = | ChEMBL = | synonyms = Benzelstilbestrol | C=25 | H=26 | O=2 | molecular_weight = 358.473 g/mol | smiles = CC/C(=C(/CC)\\C1=CC=C(C=C1)OCC2=CC=CC=C2)/C3=CC=C(C=C3)O | StdInChI_Ref = | StdInChI = 1S/C25H26O2/c1-3-24(20-10-14-22(26)15-11-20)25(4-2)21-12-16-23(17-13-21)27-18-19-8-6-5-7-9-19/h5-17,26H,3-4,18H2,1-2H3/b25-24+ | StdInChIKey_Ref = | StdInChIKey = FVLDPSZNPFWQQP-OCOZRVBESA-N }}Diethylstilbestrol monobenzyl ether (brand names Monozol, Hypantin, Pituitrope), also known as benzelstilbestrol, is a synthetic, nonsteroidal estrogen of the stilbestrol group and an ether of diethylstilbestrol (DES) that is described as a pituitary gland inhibitor (antigonadotropin) and was formerly marketed but is now no longer available.[1][2] It was first synthesized by Wallace & Tiernan Company in 1952, and was described by them as having only weak estrogenic activity.[3] The drug was used to treat gynecological conditions and infertility in women.[2] See also
References1. ^{{cite book|author=J. Elks|title=The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies|url=https://books.google.com/books?id=0vXTBwAAQBAJ&pg=PA397|date=14 November 2014|publisher=Springer|isbn=978-1-4757-2085-3|page=397}} {{Estrogens and antiestrogens}}{{Estrogen receptor modulators}}{{Genito-urinary-drug-stub}}2. ^1 {{cite book|author1=Margaret Marsh|author2=Wanda Ronner|title=The Fertility Doctor: John Rock and the Reproductive Revolution|url=https://books.google.com/books?id=WiW1qeQxYM8C&pg=PA144|date=29 December 2010|publisher=JHU Press|isbn=978-1-4214-0208-6|pages=144–}} 3. ^{{cite book|author=Ronald George Harrison|title=Studies on Fertility|url=https://books.google.com/books?id=GdNEAAAAYAAJ|year=1957|publisher=Blackwell|pages=135–136}} 3 : Estrogen ethers|Phenols|Synthetic estrogens |
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