| 词条 | Dihydrokainic acid |
| 释义 |
| ImageFile = Dihydrokainic acid.svg | ImageSize = 200px | ImageAlt = | IUPACName = (3S,4R)-3-(Carboxymethyl)-4-isopropyl-L-proline | OtherNames = Dihydrokainate; DHK | Section1 = {{Chembox Identifiers | CASNo = 52497-36-6 | PubChem = 107883 | ChemSpiderID =97018 | ChEMBL = 279561 | ChEBI = 43562 | Beilstein = 84942 | SMILES = CC(C)[C@H]1CN[C@@H]([C@H]1CC(=O)O)C(=O)O | StdInChI=1S/C10H17NO4/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13/h5-7,9,11H,3-4H2,1-2H3,(H,12,13)(H,14,15)/t6-,7+,9-/m0/s1 | StdInChIKey = JQPDCKOQOOQUSC-OOZYFLPDSA-N | Section2 = {{Chembox Properties | C=10|H=17|N=1|O=4 | Appearance = | Density = | MeltingPt = | BoilingPt = | Solubility = | Section3 = {{Chembox Hazards | MainHazards = | FlashPt = | AutoignitionPt = | GHSPictograms = {{GHS07}} | GHSSignalWord = Warning | HPhrases = {{H-phrases|302|312|332 }} | PPhrases = {{P-phrases|261|264|270|271|280|301+312|302+352|304+312|304+340|312|322|330|363|501}} }}Dihydrokainic acid is an organic compound that contains two carboxylic acid functional groups, making it a dicarboxylic acid. It is an inhibitor of the GLT-1 glutamate transporter.[1] See also
References1. ^{{Cite journal | pmid = 12420313| year = 2002| author1 = Kawahara| first1 = K| title = Selective blockade of astrocytic glutamate transporter GLT-1 with dihydrokainate prevents neuronal death during ouabain treatment of astrocyte/neuron cocultures| journal = Glia| volume = 40| issue = 3| pages = 337–49| last2 = Hosoya| first2 = R| last3 = Sato| first3 = H| last4 = Tanaka| first4 = M| last5 = Nakajima| first5 = T| last6 = Iwabuchi| first6 = S| doi = 10.1002/glia.10133}} {{Glutamate metabolism and transport modulators}}{{organic-compound-stub}} 3 : Dicarboxylic acids|Isopropyl compounds|Pyrrolidines |
| 随便看 |
|
开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。