| 词条 | Dorothea Fiedler |
| 释义 |
| image = Dorothea Fiedler (Director) at 25th anniversary of the FMP.jpg | image_size = 200 | alt = Dorothea Fiedler | caption = Dorothea Fiedler at the 25th anniversary of the FMP | name = Dorothea Fiedler | home_town = Hamburg | education = University of Würzburg (Diplom 2001), University of California at Berkeley (PhD 2005) | doctoral_advisor = Kenneth N. Raymond, Robert G. Bergman | academic_advisors = Kevan M. Shokat | workplaces = Princeton University, Leibniz-Forschungsinstitut für Molekulare Pharmakologie | awards = | residence = Germany, USA }} Dorothea Fiedler is a chemical biologist and also the first female director of the Leibniz-Forschungsinstitut für Molekulare Pharmakologie (Leibniz Research Institute for Molecular Pharmacology, FMP) in Berlin, Germany. Early life and educationFiedler grew up in Hamburg.[1] She studied inorganic chemistry at the University of Würzburg,[2] then carried out doctorate research on organometallic chemistry at the University of California at Berkeley.[1][3] Research and careerAlthough her PhD research focussed on organometallic chemistry[4][5] including host-guest systems and applications to catalysis,[6][7] Fiedler became interested in cellular signal transduction pathways during her postdoctoral research at the University of California, San Francisco.[1][8] She started her independent career as an assistant professor at Princeton University in 2010.[9] Her research focuses on the synthesis and signalling roles of inositol phosphates,[10] in particular, those with a pyrophosphate functionality,[11][12][13][14] which has relevance to cellular signalling and cancer biology.[15][16] In 2015, Fiedler became the director of the Leibniz-Forschungsinstitut für Molekulare Pharmakologie as well as a professor of chemistry at the Humboldt University of Berlin.[17] She continues developing her research focus on the synthesis and signalling roles of protein modifications involving pyrophosphates,[18][19] as well as building collaborations on biological chemistry and catalysis.[20] Funding, service, and awardsFiedler has received a New Innovator Award totalling over $2 million from the NIH in 2013.[21] She also received funding from the Sidney Kimmel Foundation for Cancer Research[22][23] and the Rita Allen Foundation.[24] During her postdoctoral research, she received the Ernst Schering Foundation Postdoctoral Fellowship, was on the Fastrack Program of the Robert Bosch Foundation, and obtained an NIH Pathway to Independence Award.[25] Fiedler is an invited speaker at the EMBO conference on Chemical Biology 2016[26] and at the International Symposium on Bioorganic Chemistry in 2017.[27] Fiedler is one of the local organizers of the 42nd National Organic Chemistry Symposium by the organic division of the American Chemical Society in 2011.[28] References1. ^1 2 {{Cite web|url=https://www.leibniz-fmp.de/press-media/press-releases/press-releases-single-view1/article/dorothea-fiedler-is-a-new-director-at-the-fmp.html|title=FMP Berlin: Dorothea Fiedler is a new director at the FMP|website=www.leibniz-fmp.de|date=2015-07-14|access-date=2019-03-07}} {{authority control}}{{DEFAULTSORT:Fiedler, Dorothea}}2. ^{{Cite web|url=https://www.uni-wuerzburg.de/alumni/news-gesichter/alumni-im-portraet/alumni-portraet-single/news/dorothea-fiedler-chemie-humboldt-universitaet-berlin/|title=Dorothea Fiedler, Chemie, Humboldt-Universität Berlin|website=www.uni-wuerzburg.de|language=de|access-date=2019-03-17}} 3. ^{{Cite web|url=https://www.gdch.de/netzwerk-strukturen/gdch-campus-event/frankfurt-am-main-17-oktober-2018/dorothea-fiedler.html|title=Dorothea Fiedler {{!}} Gesellschaft Deutscher Chemiker e.V.|website=www.gdch.de|language=de|access-date=2019-03-07}} 4. ^{{Cite journal|last=Fiedler|first=Dorothea|last2=Pagliero|first2=Daniela|last3=Brumaghim|first3=Julia L.|last4=Bergman|first4=Robert G.|last5=Raymond|first5=Kenneth N.|date=2004-01-15|title=Encapsulation of Cationic Ruthenium Complexes into a Chiral Self-Assembled Cage|url=https://pubs.acs.org/doi/10.1021/ic035105s|journal=Inorganic Chemistry|volume=43|issue=3|pages=846–848|doi=10.1021/ic035105s|issn=0020-1669|via=}} 5. ^{{Cite journal|last=Fiedler|first=Dorothea|last2=Leung|first2=Dennis H.|last3=Bergman|first3=Robert G.|last4=Raymond|first4=Kenneth N.|date=2004-03-06|title=Enantioselective Guest Binding and Dynamic Resolution of Cationic Ruthenium Complexes by a Chiral Metal−Ligand Assembly|url=https://pubs.acs.org/doi/10.1021/ja039225a|journal=Journal of the American Chemical Society|volume=126|issue=12|pages=3674–3675|doi=10.1021/ja039225a|issn=0002-7863|via=}} 6. ^{{Cite journal|last=Fiedler|first=Dorothea|last2=van Halbeek|first2=Herman|last3=Bergman|first3=Robert G.|last4=Raymond|first4=Kenneth N.|date=2006-07-19|title=Supramolecular Catalysis of Unimolecular Rearrangements: Substrate Scope and Mechanistic Insights|url=https://pubs.acs.org/doi/10.1021/ja062329b|journal=Journal of the American Chemical Society|volume=128|issue=31|pages=10240–10252|doi=10.1021/ja062329b|issn=0002-7863|via=}} 7. ^{{Cite journal|last=Fiedler|first=Dorothea|last2=Leung|first2=Dennis H.|last3=Bergman|first3=Robert G.|last4=Raymond|first4=Kenneth N.|date=2005-04-01|title=Selective Molecular Recognition, C−H Bond Activation, and Catalysis in Nanoscale Reaction Vessels|url=https://doi.org/10.1021/ar040152p|journal=Accounts of Chemical Research|volume=38|issue=4|pages=349–358|doi=10.1021/ar040152p|issn=0001-4842}} 8. ^{{Cite journal|last=Fiedler|first=Dorothea|last2=Braberg|first2=Hannes|last3=Mehta|first3=Monika|last4=Chechik|first4=Gal|last5=Cagney|first5=Gerard|last6=Mukherjee|first6=Paromita|last7=Silva|first7=Andrea C.|last8=Shales|first8=Michael|last9=Collins|first9=Sean R.|date=2009-03-05|title=Functional Organization of the S. cerevisiae Phosphorylation Network|url=https://linkinghub.elsevier.com/retrieve/pii/S0092867409000026|journal=Cell|volume=136|issue=5|pages=952–963|doi=10.1016/j.cell.2008.12.039|pmc=2856666|pmid=19269370|via=}} 9. ^{{Cite book|url=https://books.google.de/books?id=iSJbAAAAYAAJ&pg=PT629&lpg=PT629&dq=princeton+dorothea+fiedler&source=bl&ots=3RkZeqQ6JS&sig=ACfU3U2vIewuBfwAWz93hs3MfeJyvS-ifg&hl=en&sa=X&ved=2ahUKEwjduNaRgYrhAhXI5KQKHTd6DXU4FBDoATAAegQIBBAB#v=onepage&q=princeton%20dorothea%20fiedler&f=false|title=Princeton Alumni Weekly|last=|first=|date=2009-06-10|publisher=princeton alumni weekly|year=|isbn=|location=|pages=}} 10. ^{{Cite web|url=https://www.princeton.edu/chemistry/fiedler/research/|title=Research - Fiedler Group|website=www.princeton.edu|access-date=2019-03-17}} 11. ^{{Cite web|url=https://www.chemistryviews.org/details/ezine/7278491/Lost_in_Post-Translation.html|title=Lost in Post-Translation :: ChemViews Magazine :: ChemistryViews|last=Campbell|first=Meghan|date=2015-02-05|website=www.chemistryviews.org|archive-url=|archive-date=|dead-url=|access-date=2019-03-17}} 12. ^{{Cite journal|last=Wu|first=Mingxuan|last2=Dul|first2=Barbara E.|last3=Trevisan|first3=Alexandra J.|last4=Fiedler|first4=Dorothea|date=2013|title=Synthesis and characterization of non-hydrolysable diphosphoinositol polyphosphate messengers|url=http://xlink.rsc.org/?DOI=C2SC21553E|journal=Chem. Sci.|volume=4|issue=1|pages=405–410|doi=10.1039/C2SC21553E|issn=2041-6520|pmc=3558982|pmid=23378892}} 13. ^{{Cite journal|last=Williams|first=Florence J.|last2=Fiedler|first2=Dorothea|date=2015-09-18|title=A Fluorescent Sensor and Gel Stain for Detection of Pyrophosphorylated Proteins|url=http://pubs.acs.org/doi/10.1021/acschembio.5b00256|journal=ACS Chemical Biology|volume=10|issue=9|pages=1958–1963|doi=10.1021/acschembio.5b00256|issn=1554-8929}} 14. ^{{Cite journal|last=Marmelstein|first=Alan M.|last2=Yates|first2=Lisa M.|last3=Conway|first3=John H.|last4=Fiedler|first4=Dorothea|date=2014-01-08|title=Chemical Pyrophosphorylation of Functionally Diverse Peptides|url=http://pubs.acs.org/doi/10.1021/ja411737c|journal=Journal of the American Chemical Society|volume=136|issue=1|pages=108–111|doi=10.1021/ja411737c|issn=0002-7863|pmc=3992712|pmid=24350643}} 15. ^{{Cite journal|last=Shears|first=Stephen B.|date=2014-10-05|title=Inositol pyrophosphates: Why so many phosphates?|url=https://linkinghub.elsevier.com/retrieve/pii/S2212492614000542|journal=Advances in Biological Regulation|volume=57|pages=203–216|doi=10.1016/j.jbior.2014.09.015|pmc=4291286|pmid=25453220|via=}} 16. ^{{Cite journal|last=Shah|first=Akruti|last2=Ganguli|first2=Shubhra|last3=Sen|first3=Jayraj|last4=Bhandari|first4=Rashna|date=2017-02-28|title=Inositol Pyrophosphates: Energetic, Omnipresent and Versatile Signalling Molecules|url=http://link.springer.com/10.1007/s41745-016-0011-3|journal=Journal of the Indian Institute of Science|volume=97|issue=1|pages=23–40|doi=10.1007/s41745-016-0011-3|issn=0970-4140|via=}} 17. ^{{Cite web|url=https://agnes.hu-berlin.de/lupo/rds?state=verpublish&status=init&vmfile=no&moduleCall=webInfo&publishConfFile=webInfoPerson&keep=y&publishSubDir=personal&personal.pid=27099|title=Humboldt-Universität zu Berlin - Dorothea Fiedler|website=agnes.hu-berlin.de|access-date=2019-03-17}} 18. ^{{Cite journal|last=Yates|first=Lisa M.|last2=Fiedler|first2=Dorothea|date=2016-04-15|title=A Stable Pyrophosphoserine Analog for Incorporation into Peptides and Proteins|url=http://pubs.acs.org/doi/10.1021/acschembio.5b00972|journal=ACS Chemical Biology|volume=11|issue=4|pages=1066–1073|doi=10.1021/acschembio.5b00972|issn=1554-8929}} 19. ^{{Cite journal|last=Marmelstein|first=Alan M.|last2=Morgan|first2=Jeremy A. M.|last3=Penkert|first3=Martin|last4=Rogerson|first4=Daniel T.|last5=Chin|first5=Jason W.|last6=Krause|first6=Eberhard|last7=Fiedler|first7=Dorothea|date=2018|title=Pyrophosphorylation via selective phosphoprotein derivatization|url=http://xlink.rsc.org/?DOI=C8SC01233D|journal=Chemical Science|volume=9|issue=27|pages=5929–5936|doi=10.1039/C8SC01233D|issn=2041-6520|pmc=6050540|pmid=30079207}} 20. ^{{Cite web|url=https://www.unisyscat.tu-berlin.de/research-units/signal-controlled-multicomponent-catalysis.html|title=UniSysCat: Signal-controlled multicomponent catalysis|website=www.unisyscat.tu-berlin.de|access-date=2019-03-17}} 21. ^{{Cite web|url=http://grantome.com/grant/NIH/DP2-CA186753-01|title=Understanding phosphate metabolism in cancer and metastasis|last=Fiedler|first=Dorothea|date=2013|website=Grantome|archive-url=|archive-date=|dead-url=|access-date=2019-03-17}} 22. ^{{Cite web|url=https://www.prweb.com/releases/Sidney_Kimmel/cancer_research/prweb10774468.htm|title=The Sidney Kimmel Foundation for Cancer Research Announces 2013 Grant Recipients|website=PRWeb|access-date=2019-03-17}} 23. ^{{Cite web|url=http://kimmel.org/kimmel-scholars/our-scholars/|title=Our Scholars|website=Sidney Kimmel Foundation|access-date=2019-03-17}} 24. ^{{Cite web|url=http://ritaallen.org/scholar-year/2013/|title=Years 2013 - Rita Allen Foundation|access-date=2019-03-17}} 25. ^{{Cite web|url=https://www.unisyscat.tu-berlin.de/group-leaders/fiedler-dorothea.html|title=UniSysCat: Fiedler, Dorothea|website=www.unisyscat.tu-berlin.de|access-date=2019-03-17}} 26. ^{{Cite web|url=https://www.embl.de/training/events/2016/CHB16-01/speakers_gallery/|title=EMBO Conference - Chemical Biology 2016 - Speakers|website=www.embl.de|access-date=2019-03-17}} 27. ^{{Cite web|url=https://www.uni-konstanz.de/en/isboc-11/programme/speakers/|title=Speakers {{!}} Programme {{!}} International Symposium on Bioorganic Chemistry (ISBOC-11) & Konstanz Symposium Chemical Biology {{!}} University of Konstanz|website=www.uni-konstanz.de|access-date=2019-03-17}} 28. ^{{Cite web|url=https://www.organicdivision.org/noshistory/|title=- NOS History|website=ACS Division of Organic Chemistry|access-date=2019-03-17}} 12 : Year of birth missing (living people)|Living people|People from Hamburg|University of Würzburg alumni|Humboldt University of Berlin faculty|Princeton University faculty|German expatriates in the United States|German women biologists|20th-century German scientists|21st-century German scientists|20th-century German women|21st-century German women |
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