| 词条 | Draft:Annealases |
| 释义 |
Most annealases are DNA recombination proteins, though some may have additional activities resulting in multi-functionality. Most, if not all, annealases found in dsDNA viruses form a complex with its partner viral exonuclease to form a DNA recombinase referred to as an EATR complex (Exonuclease Annealase Two-component Recombinase). EATR complexes act as recombinases that catalyze a ssDNA annealing homologous DNA recombination reaction, which is commonly referred to as a single-strand annealing (SSA) homologous recombination. Annealases are different from the ATP-dependent strand invasion proteins such as the E. coli RecA DNA recombination protein. Redβ annealase of bacteriophage lambda (phage λ) is most likely the first annealase identified. Note: Further editing will follow. {{AFC submission|t||ts=20180816162130|u=TolunG|ns=118|demo=}}References1. ^{{Cite thesis|last=Tolun|first=Gökhan|title=More than the Sum of Its Parts: Physical and Mechanistic Coupling in the Phage Lambda Red Recombinase|date=2007|degree=Ph.D.|publisher=University of Miami|url=https://scholarlyrepository.miami.edu/oa_dissertations/29/|doi=|language=en}} |
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