| 词条 | Draft:CRZ1 |
| 释义 |
CRZ1, for Calcineurin-Responsive Zinc Finger 1, is a transcription factor that regulates calcineurin dependent-genes in Candida albicans[1]. Mechanism of actionThe cytoplasmic protein Crz1 is dephosphorylated by the calcineurin and is then targeted to the nucleus[2]. The nuclear protein activates the transcription of genes involved in cell-wall maintenance and ion homeostasis [3][4]. References1. ^{{Cite journal|last=Steinbach|first=William J.|last2=Reedy|first2=Jennifer L.|last3=Cramer|first3=Robert A.|last4=Perfect|first4=John R.|last5=Heitman|first5=Joseph|date=June 2007|title=Harnessing calcineurin as a novel anti-infective agent against invasive fungal infections|url=https://www.ncbi.nlm.nih.gov/pubmed/?term=Harnessing+calcineurin+as+a+novel+anti-infective+agent+against+invasive+fungal+infections|journal=Nature Reviews. Microbiology|volume=5|issue=6|pages=418–430|doi=10.1038/nrmicro1680|issn=1740-1534|pmid=17505522}} 2. ^{{Cite journal|last=Stathopoulos-Gerontides|first=A.|last2=Guo|first2=J. J.|last3=Cyert|first3=M. S.|date=1999-04-01|title=Yeast calcineurin regulates nuclear localization of the Crz1p transcription factor through dephosphorylation|url=https://www.ncbi.nlm.nih.gov/pubmed/10197980|journal=Genes & Development|volume=13|issue=7|pages=798–803|issn=0890-9369|pmid=10197980}} 3. ^{{Cite journal|last=Steinbach|first=William J.|last2=Reedy|first2=Jennifer L.|last3=Cramer|first3=Robert A.|last4=Perfect|first4=John R.|last5=Heitman|first5=Joseph|date=June 2007|title=Harnessing calcineurin as a novel anti-infective agent against invasive fungal infections|url=https://www.ncbi.nlm.nih.gov/pubmed/?term=Harnessing+calcineurin+as+a+novel+anti-infective+agent+against+invasive+fungal+infections|journal=Nature Reviews. Microbiology|volume=5|issue=6|pages=418–430|doi=10.1038/nrmicro1680|issn=1740-1534|pmid=17505522}} 4. ^{{Cite journal|last=Stathopoulos|first=A. M.|last2=Cyert|first2=M. S.|date=1997-12-15|title=Calcineurin acts through the CRZ1/TCN1-encoded transcription factor to regulate gene expression in yeast|url=https://www.ncbi.nlm.nih.gov/pubmed/9407035?dopt=Abstract&holding=npg|journal=Genes & Development|volume=11|issue=24|pages=3432–3444|issn=0890-9369|pmid=9407035}} |
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